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1.
J Biomed Mater Res B Appl Biomater ; 101(3): 436-40, 2013 Apr.
Article in English | MEDLINE | ID: mdl-23115033

ABSTRACT

Vitamin E stabilization of radiation crosslinked ultrahigh molecular weight polyethylene (UHMWPE) for total joint implants can be done by blending of UHMWPE resin powder with vitamin E, followed by consolidation and irradiation of the blend. It is well known that vitamin E prevents crosslinking in UHMWPE during ionizing radiation. We hypothesized that there would also be a significant amount of grafting of vitamin E onto UHMWPE during irradiation. Spectroscopic analysis of radiation crosslinked vitamin E-blended UHMWPE before and after extraction with boiling hexane showed vitamin E grafting in up to 30% of the blended vitamin E. Grafting increased with irradiation temperature. We also discovered that increasing irradiation temperature resulted in better preservation of active vitamin E in the polymer and increased crosslinking efficiency of UHMWPE. As a result, warm-irradiated vitamin E-blended UHMWPEs had significantly less wear than those irradiated at ambient temperature. It may be desirable to graft vitamin E on UHMWPE to decrease the possibility of elution and increase long-term stability. Warm irradiation of vitamin E blends may present an advantage in increasing vitamin E potency, as well as decreasing the wear of UHMWPE, which is crucial in decreasing the incidence of periprosthetic osteolysis in total joint replacement patients.


Subject(s)
Arthroplasty, Replacement , Materials Testing , Vitamin E/chemistry , Temperature
2.
J Arthroplasty ; 27(1): 95-104, 2012 Jan.
Article in English | MEDLINE | ID: mdl-21550762

ABSTRACT

Wear and damage of ultrahigh molecular weight polyethylene (UHMWPE) tibial inserts used in total knee arthroplasty are accelerated by oxidation. Radiation crosslinking reduces wear but produces residual free radicals adversely affecting stability. One alternative to stabilize radiation-crosslinked UHMWPE is to infuse the material with vitamin E (vit E). We investigated the properties of 100-kGy e-beam-irradiated UHMWPE that was subsequently doped with vitamin E in comparison with conventional UHMWPE. Both polymers were sterilized with gamma irradiation in vacuum packaging. Vitamin E-doped UHMWPE showed lower wear before and after aging (2.4 ± 0.5 and 2.5 ± 0.8 mg/million cycle, respectively, vs 26.9 ± 3.5 and 40.8 ± 3.0 mg/million cycle for conventional UHMWPE). Conventional UHMWPE showed oxidation after accelerated aging, and its mechanical properties were adversely affected, whereas vit E-doped UHMWPE showed no oxidation or changes in its mechanical properties. Vitamin E stabilization of radiation-crosslinked UHMWPE resulted in low wear and high oxidation resistance; it is an alternative load-bearing material for total knee applications.


Subject(s)
Antioxidants , Knee Prosthesis , Materials Testing , Polyethylenes , Vitamin E , Models, Anatomic , Prosthesis Design
3.
Biomaterials ; 31(27): 7051-60, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20579730

ABSTRACT

Wear particle-induced periprosthetic osteolysis has been a clinical problem driving the development of wear resistant ultrahigh molecular weight polyethylene (UHMWPE) for total joint replacement. Radiation crosslinking has been used to decrease wear through decreased plastic deformation; but crosslinking also reduces mechanical properties including fatigue resistance, a major factor limiting the longevity of joint implants. Reducing UHMWPE wear with minimal detriment to mechanical properties is an unaddressed need for articular bearing surface development. Here we report a novel approach to achieve this by limiting crosslinking to the articular surface. The antioxidant vitamin E reduces crosslinking efficiency in UHMWPE during irradiation with increasing concentration, thus we propose to spatially control the crosslink density distribution by controlling the vitamin E concentration profile. Surface crosslinking UHMWPE prepared using this approach had high wear resistance and decreased crosslinking in the bulk resulting in high fatigue crack propagation resistance. The interface region did not represent a weakness in the material due to the gradual change in the crosslink density. Such an implant has the potential of decreasing risk of fatigue fracture of total joint implants as well as expanding the use of UHMWPE to younger and more active patients.


Subject(s)
Polyethylenes/chemistry , Vitamin E/chemistry , Arthroplasty, Replacement/methods , Joint Prosthesis , Materials Testing , Molecular Weight
4.
J Biomed Mater Res B Appl Biomater ; 90(2): 720-9, 2009 Aug.
Article in English | MEDLINE | ID: mdl-19213055

ABSTRACT

Ultrahigh molecular weight polyethylene (UHMWPE) is a bearing surface material for total joint implants. It is radiation cross-linked for high wear resistance and is melted or treated with vitamin E for oxidative stability. We investigated high pressure crystallization (HPC) of irradiated UHMWPE as an alternative method to improve the mechanical strength while stabilizing the residual free radicals from radiation cross-linking. HPC of uncross-linked UHMWPE has resulted in the formation of extended chain crystals and increased crystallinity, leading to improved strength. We hypothesized that increased cross-link density would hinder crystallization during HPC due to decreased chain mobility. Therefore, we investigated the crystalline structure and tensile mechanical properties of high pressure crystallized 25-, 65- and 100-kGy irradiated UHMWPE. We also determined free radical content and wear. The strength of 25- and 65-kGy irradiated UHMWPEs was improved by HPC with increased crystallinity and crystal size. 100-kGy irradiated UHMWPE did not show improved strength, supporting our hypothesis that decreased chain mobility would hinder crystal formation and strength improvement. None of the HPC irradiated UHMWPEs contained detectable free radicals and their wear properties were maintained, suggesting oxidative and mechanical stability in the long term. Therefore, HPC can be used effectively for imparting oxidative stability while strength improvement can be achieved for irradiated UHMWPE with low to moderate cross-link density.


Subject(s)
Cross-Linking Reagents/pharmacology , Polyethylenes/chemistry , Crystallization , Dose-Response Relationship, Radiation , Free Radicals , Hip Prosthesis , Materials Testing , Microscopy, Electron, Transmission , Oxygen/chemistry , Pressure , Stress, Mechanical , Tensile Strength
5.
Biomaterials ; 30(10): 1870-80, 2009 Apr.
Article in English | MEDLINE | ID: mdl-19135247

ABSTRACT

Higher crystallinity and extended chain morphology are induced in ultra-high molecular weight polyethylene (UHMWPE) in the hexagonal phase at temperatures and pressures above the triple point, resulting in improved mechanical properties. In this study, we report the effects of the presence of a plasticizing agent, namely vitamin E (alpha-tocopherol), in UHMWPE during high pressure crystallization. We found that this new vitamin E-blended and high pressure crystallized UHMWPE (VEHPE) has improved fatigue strength and wear resistance compared to virgin high pressure crystallized (HP) UHMWPE. This suggested different mechanisms of wear reduction and fatigue crack propagation resistance in UHMWPE.


Subject(s)
Polyethylenes/chemistry , Vitamin E/chemistry , Biocompatible Materials/chemistry , Calorimetry, Differential Scanning , Crystallization , Materials Testing , Stress, Mechanical , X-Ray Diffraction
6.
Acta Orthop ; 77(5): 710-8, 2006 Oct.
Article in English | MEDLINE | ID: mdl-17068700

ABSTRACT

BACKGROUND: The advent of highly crosslinked polyethylene has allowed the re-evaluation of the use of femoral heads larger than 32 mm for metal-on-polyethylene total hip arthroplasties. However, the effect of larger heads on the frictional torque of highly crosslinked polyethylene is unknown. METHODS: We performed an in vitro examination of the effect of larger chrome cobalt femoral heads (40 mm diameter) on the frictional torque and torsional resistance of hip articulations on aged liners of polyethylene that were sterilized by gamma rays while in nitrogen, and aged highly crosslinked polyethylene. The frictional torque at the femoral head articulation was usually higher for the highly crosslinked polyethylene than for the conventional polyethylene. The aged conventional liners oxidized considerably, which led to gross failure of the polyethylene at the anti-rotation portion of the rim. The aged crosslinked polyethylene showed no such failures despite the higher frictional torque. INTERPRETATION: Our findings suggest that in terms of torsional resistance to fatigue when studied as a device, rather than as an isolated material, under these conditions, aged highly crosslinked polyethylene is preferable to aged conventional polyethylene.


Subject(s)
Biomechanical Phenomena , Femur Head , Materials Testing , Polyethylenes , Arthroplasty, Replacement, Hip/adverse effects , Arthroplasty, Replacement, Hip/methods , Cross-Linking Reagents , Friction , Hip Prosthesis/adverse effects , Humans , In Vitro Techniques , Prosthesis Design , Prosthesis Failure , Surface Properties , Time Factors , Torsion Abnormality
7.
J Arthroplasty ; 21(7): 1054-63, 2006 Oct.
Article in English | MEDLINE | ID: mdl-17027551

ABSTRACT

The ideal surface for cemented femoral components remains controversial. Six polished stems were compared with 6 rough stems both with good cement mantle and also with poor cement mantles in a stair-climbing model. With good cement mantles, both the polished and the rough stems were loose by 6 million cycles. However, none were loose by radiographic criteria. With the poor cement mantle, both stems became loose earlier and developed more micromotion, the polished stems having significantly higher and earlier motion than the rough. Radiographic evidence of debonding was not visible until the stems had motion of more than 2,000 microm. In the presence of a good cement mantle in this laboratory model there was no significant difference in the development of micromotion under fatigue stair-climbing conditions between a polished or grit-blasted femoral component. However, in the presence of a poor cement mantle, the polished components had earlier and higher micromotion. This study reinforces the importance of centralization and cement technique, particularly if using a polished surface finish.


Subject(s)
Arthroplasty, Replacement, Hip/instrumentation , Hip Prosthesis , Humans , Motion , Prosthesis Design , Prosthesis Failure , Surface Properties
8.
J Arthroplasty ; 21(1): 122-8, 2006 Jan.
Article in English | MEDLINE | ID: mdl-16446196

ABSTRACT

The search for improved femoral fixation in cemented total hip arthroplasty is ongoing. Two design variables, surface finish and stem contour, were evaluated. Sixteen titanium femoral stems of one design were cemented into fiberglass femora. One half of the components had a polished surface and the rest had a roughened finish. Within each group, 4 stems had vertically oriented ribs on the proximal portion and 4 did not. Micromotion was measured in a stair climbing simulator with loading to a joint reaction force of 200 kg for 6 million cycles. Micromotion increased throughout the course of the experiment. Stems with a polished surface had significantly higher micromotion. Although stems with ribs had less micromotion compared with those without ribs, this difference was not statistically significant.


Subject(s)
Femur , Hip Prosthesis , Analysis of Variance , Biomechanical Phenomena , Cementation , In Vitro Techniques , Linear Models , Materials Testing , Prosthesis Design , Prosthesis Failure , Stress, Mechanical , Surface Properties , Titanium
9.
J Bone Joint Surg Am ; 84(4): 573-9, 2002 Apr.
Article in English | MEDLINE | ID: mdl-11940617

ABSTRACT

BACKGROUND: Several studies have shown that certain cemented total hip replacement femoral stems have been associated with the complications of early debonding, loosening, and osteolysis. Some authors have suggested that these failures may be related to the surface finish of the stems. We developed an in vitro biomechanical experiment characterized by simulated stair-climbing to investigate the multiple factors involved in loosening of cemented femoral stems. In this study, we measured the effects of stem neck length, body weight, stem size, and calcar-collar contact on the torsional stability, as reflected by the strains in the proximal cement mantle, of one design of cemented femoral stem. METHODS: Eight Centralign femoral stems (Zimmer, Warsaw, Indiana) were cemented into eight cadaver femora with use of contemporary cementing techniques. Prior to insertion, fifteen strain-gauge rosettes were mounted around the proximal portion of the stem. The stems were loaded on a jig that simulated static peak loading during stair-climbing. Loading was repeated for each stem with three different joint reaction forces and for three different neck lengths. Calcar loading by the collar was then eliminated by removing a 0.5-mm slice of bone beneath the collar, and all loadings were then repeated. RESULTS: The peak principal tensile strains in the proximal cement increased linearly with both body weight (r (2) > 0.95) and neck length (r (2) > 0.75). Increasing body weight affected the peak cement strains far more than did increasing neck length. During simulated stair-climbing, calcar-collar contact reduced peak strains in the proximal cement by a factor of 1.5 to two. Peak principal tensile strains in the proximal cement often exceeded 1000 me when the smaller stems were used. CONCLUSIONS: In this stair-climbing test model, the peak proximal cement strains were increased more by changes in body weight than they were by changes in neck length. Even during stair-climbing, calcar-collar contact reduced peak cement strains.


Subject(s)
Body Weight , Bone Cements , Femur/anatomy & histology , Hip Prosthesis , Prosthesis Failure , Weight-Bearing , Biomechanical Phenomena , Cadaver , Humans , Prosthesis Design , Stress, Mechanical
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