Iron Removal from Metallurgical Grade Silicon Melts Using Synthetic Slags and Oxygen Injection.

Novel SiO2-CaO-CaF2-R2O-MgO based synthetic slags (R2O represents alkali metal oxides) with varied binary basicity values were used with oxygen injection to refine silicon melts and remove Fe from metallurgical-grade silicon. Silicon samples and slags at the silicon-slag interfaces were obtained during refinement. The compositions of the silicon samples were analyzed, and the quenched slag samples and mild cooling slags from the final crucible were inspected using scanning electron microscopy and energy dispersive X-ray spectroscopy. After 15 min of refinement, the Fe removal rate ranged from 52.3 to 60.1 wt%. During the refining process, the Fe-concentrated phase formed within the silicon droplets and was then transferred to the silicon-slag interfaces and wetted with slags. The Fe-concentrated phase at the silicon-slag interface can dissolve directly in the slags. It can also be transferred into the slag phase in the form of droplets, which can be affected by the binary basicity of the slags. Ti removal demonstrated a similar mechanism. Fe-bearing crystals were not detected in the quenched slag samples obtained during refinement, while complex Fe-bearing phases were detected in the final slag. This study demonstrates Fe removal from metallurgical-grade Si using slag refining methods and reveals the removal mechanism during the refinement.

Multidisciplinary care in patients with systemic lupus erythematosus: a randomized controlled trial in China.

Background For the large number of systemic lupus erythematosus (SLE) patients in China, it is critical to carry out effective disease management to improve the treatment effect and reduce disease burden. A pharmacist-led multidisciplinary care model has not been reported in Chinese SLE patients before. Objective To assess the effect of patient-centered, pharmacist-led, multidisciplinary care on clinical outcomes and satisfaction with health care in Chinese SLE patients. Setting: The South Campus, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. Method Participants were 143 systemic lupus erythematosus patients randomly assigned to either the intervention group (multidisciplinary care: physician, pharmacist and nurse) or the control group (usual care only). Main outcome measures The primary outcome was scores on the systemic lupus erythematosus disease activity index-2000, the satisfaction with information about medicines scale, and the EuroQol five-dimension questionnaire, assessed at baseline and 12 months. Results Between October 1, 2017 and October 1, 2018, 42 participants were included in the intervention group and 40 in the control group. At 12 months, results for the systemic lupus erythematosus disease activity index-2000 differed significantly between the intervention group and the control group (0 vs. 2, P = 0.027). Patient satisfaction with health care was also significantly greater in the intervention group than in the control group (92.9 vs. 0%, P = 0.000). According to the EuroQol five-dimension questionnaire, health quality was also improved (0.94 vs. 0.85, P = 0.006). Conclusion Our multidisciplinary care team significantly improved clinical outcomes and satisfaction with drug information in Chinese systemic lupus erythematosus patients.

pH sensitive peptide functionalized nanoparticles for co-delivery of erlotinib and DAPT to restrict the progress of triple negative breast cancer.

Although a variety of drug delivery strategies have been designed for enhancing the treatment of Triple negative breast cancer (TNBC), combating with TNBCs is still dramatically challenged by the selection of appropriate therapeutic targets and insufficient tumor accumulation or inner penetration of chemotherapeutics. To address these issues, the classical EGFR-inhibitor, erlotinib (EB), was selected as the model drug here and PLA-based nano-platform (NP-EB) was prepared for tumor site drug delivery. Given the significant role of Notch-EGFR interplay in raising severe resistance to EGFR inhibition of EB, gamma secretase inhibitor (GSI)-DAPT was further entrapped into the core of nanoparticles to inhibit the activation of Notch signaling (NP-EB/DART). For achieving the goal of tumor targeting drug delivery, we developed a new peptide CF and decorating it on the surface of EB/DART-dual loaded nanoparticles (CF-NP-EB/DART). Such CF peptide was designed by conjugating two separated peptide CREKA, tumor-homing peptide, and F3, cell penetrating peptide, to together via a pH-sensitive hydrazone bond. By this way, the tumor unspecific property of F3 was sealed and significantly reduced the site effects. However, after the nanoparticles reach the tumor site, the pH-sensitive linkage can be broken down by the unique acidic environment of tumor, and subsequently discovered the F3 peptide to penetrate into tumor cells.

[Urban heat island intensity and its grading in Liaoning Province of Northeast China].

According to the recorded air temperature data and their continuity of each weather station, the location of each weather station, the numbers of and the distances among the weather stations, and the records on the weather stations migration, several weather stations in Liaoning Province were selected as the urban and rural representative stations to study the characteristics of urban heat island (UHI) intensity in the province. Based on the annual and monthly air temperature data of the representative stations, the ranges and amplitudes of the UHI intensity were analyzed, and the grades of the UHI intensity were classified. The Tieling station, Dalian station, Anshan station, Chaoyang station, Dandong station, and Jinzhou station and the 18 stations including Tai' an station were selected as the representative urban and rural weather stations, respectively. In 1980-2009, the changes of the annual UHI intensity in the 6 representative cities differed. The annual UHI intensity in Tieling was in a decreasing trend, while that in the other five cities was in an increasing trend. The UHI intensity was strong in Tieling but weak in Dalian. The changes of the monthly UHI intensity in the 6 representative cities also differed. The distribution of the monthly UHI intensity in Dandong, Jinzhou and Tieling took a "U" shape, with the maximum and minimum appeared in January and in May-August, respectively, indicating that the monthly UHI intensity was strong in winter and weak in summer. The ranges of the annual and monthly UHI intensity in the 6 cities were 0.57-2.15 degrees C and -0.70-4.60 degrees C, and the ranges of 0.5-2.0 degrees C accounted for 97.8% and 72.3%, respectively. The UHI intensity in the province could be classified into 4 grades, i. e., weak, strong, stronger and strongest.

Silencing CX3CR1 production modulates the interaction between dendritic and endothelial cells.

CX3CR1, an important chemokine receptor in dendritic cells (DCs), is linked to the progression of atherosclerotic plaques. However, the mechanism(s) determining the role of CX3CR1 in atherosclerosis have not been clearly elucidated. In this study, we developed DCs from monocytes of Sprague-Dawley (SD) rats in the presence of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) and recombinant human interleukin-4 (IL-4). The presence of recombinant human TNF-α and LPS forced the cells to mature. When compared to immature DCs, flow cytometry (FACS) analysis revealed that mature DCs display a sustained increase in the levels of CD11c, CD86, and CD80 expression. The expression of Fractalkine (FKN) in endothelial cells (ECs) contributes to the maturation of DCs and expression of CX3CR1. We revealed that mRNA expression levels of CX3CR1 in mature DCs are significantly higher than those of immature DCs (P<0.001). Transfection of DCs with siRNA specific for the CX3CR1 gene resulted in potent suppression of gene expression and inhibition of interactions between DCs and ECs. Based on these data, we hypothesized that CX3CR1 contributes to the DC-EC interaction. CX3CR1 may serve as a new target molecule for increasing therapeutic interactions in atherosclerosis.

[Vertical distribution of soil organic carbon and total nitrogen in reed wetland].

With element analyzer, this paper measured the variation of organic carbon and total nitrogen in different soil depths of reed wetland. The results showed that soil organic carbon, total nitrogen, and C/N ratio were decreased gradually with increasing soil depth, and their accumulation peaks were differed with soil layers and months. Soil temperature and moisture and the growth status of reed were the main factors caused the differences. Soil organic carbon was strongly positively correlated with soil total nitrogen content in July, August and October, the R2 being 0.73, 0.73 and 0.71 respectively, but weakly correlated in September. Soil C/N ratio was negatively correlated to soil organic carbon and total nitrogen, but the correlativity was higher with soil total nitrogen than with soil organic carbon, suggesting that soil C/N ratio was more determined by the content of soil total nitrogen.