Characteristics and management of tumor treating fields-related dermatological complications in patients with glioblastoma.

Tumor treating fields (TTFields) is a novel approved modality for the treatment of glioblastoma (GBM) exhibiting a satisfactory effect. Although TTFields has shown considerable safety for the normal brain, dermatological adverse events (DAEs) often occur during therapy. However, studies focused on the identification and management of DAEs are rare. The clinical data and photos of skin lesions from 9 patients with GBM were retrospectively analyzed, and the types and grades of individual scalp dermatitis were evaluated based on the Common Terminology Criteria for Adverse Events version 5.0 (CTCAE v 5.0). Adherence and safety were also evaluated on the basis of the device monitoring data. Eight patients (88.9%) exhibited grade 1 or grade 2 CTCAE DAEs, all of whom were cured after interventions. The adherence was >90%, with no relevant safety events reported. Finally, a guideline for preventing DAEs in patients with GBM was proposed. The identification and management of TTFields-related DAEs is necessary and urgent in patients with GBM. Timely interventions of DAEs will help to improve the adherence and quality of life of patients, which ultimately improves prognosis. The proposed guideline for preventing DAEs in patients with GBM assists in the management of healthcare providers and may avoid dermatologic complications.

Stability analysis for a new fractional order N species network.

The present paper considers a fractional-order N species network, in which, the general functions are used for finding general theories. The existence, uniqueness, and non-negativity of the solutions for the considered model are proved. Moreover, the local and global asymptotic stability of the equilibrium point are studied by using eigenvalue method and Lyapunov direct method. Finally, some simple examples and numerical simulations are provided to demonstrate the theoretical results.

[Observation on theraputic effect of five-needle-in-nape acupuncture for treatment of poststroke pesudobulbar paralysis dysphagia].

OBJECTIVE: To compare the therapeutic effect of five-needle-in-nape acupuncture treatment and the routine acupuncture treatment for poststroke pesudobulbar paralysis dysphagia. METHODS: Sixty cases were randomly divided into a five-needle-in-nape (FNN) group and a routine acupuncture (RA) group (n=30 in each group). Ya-men (GV 15), Tianzhu (BL10), Zhiqiang acupoint (Extra) were needled and the training of swallowing was practiced when needling in FNN group. Lianquan (CV 23), Tongli (HT 5), Zhaohai (KI 6) were needled in RA group. The course of acupuncture treatment consisted of needling once time every day, six times a week for two weeks. The therapeutic effects were evaluated after two courses of acupuncture treatment. RESULTS: The effective rate was 93.3% in FNN group, better than that of 80.0% in RA group (P < 0.05). CONCLUSION: The therapeutic effect in FNN group was better than that of RA group for poststroke pesudobulbar paralysis dysphagia.