ABSTRACT
<p><b>OBJECTIVE</b>To investigate the feasibility and advantages of transurethral transumbilical laparoendoscopic single-site surgery (TU-LESS) for radical prostatectomy.</p><p><b>METHODS</b>Five patients with prostate cancer underwent TU-LESS for radical prostatectomy, with a four-channel single-port device inserted into a 2. 5 cm periumbilical incision and another placed through the urethra, followed by analysis of the perioperative data.</p><p><b>RESULTS</b>All the operations were successfully accomplished, with neither conversion to open surgery nor additional channel. The mean operation time, intraoperative blood loss, and postoperative hospital stay were 168 min, 120 ml, and 15 d, respectively. No severe perioperative complications were observed. TNM stage classification manifested T2cN0M0 in 2 cases and T2bN0M0 in the other 3. Postoperative pathology showed no negative surgical margins in any of the cases.</p><p><b>CONCLUSION</b>TU-LESS is safe and feasible for radical prostatectomy and can reduce the complication of low urinary tract surgery by single-site laparoendoscopy.</p>
Subject(s)
Humans , Male , Blood Loss, Surgical , Feasibility Studies , Laparoscopy , Length of Stay , Natural Orifice Endoscopic Surgery , Methods , Operative Time , Prostatectomy , Methods , Prostatic Neoplasms , General Surgery , Umbilicus , General Surgery , Urologic Surgical Procedures, Male , MethodsABSTRACT
OBJECTIVE: To establish the methods of calculating and analyzing the multi-coefficient of variation significance test for the toxicology study. METHODS: The paper aimed to confirm the significance level with the method of Bonferroni and then compared the methods of calculating and analyzing of the experiment groups with the control group respectively. RESULTS: The significance level of multi-coefficient of variation significance test was confirmed as alpha1=0.0167. Compared with the control groups, the activity of ALT in serum both in 30 mg/kg and 60 mg/kg groups did not change in the average significance test, which was not statistically significant (P>0.05), while it changed in the variation significance test, which was of statistical significance (P<0.0167). The activity of AST in serum in 60 mg/kg group did not change in the average significance test (P>0.05), while it changed in the variation significance test (P<0.0167). CONCLUSION: The complete changes of the indexes can only be shown by use of both the average significance test and the variation significance test together.
