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1.
J Nanosci Nanotechnol ; 21(2): 1127-1134, 2021 02 01.
Article in English | MEDLINE | ID: mdl-33183452

ABSTRACT

Chronic pulmonary heart disease is a common respiratory disease. Helicobacter pylori infection can lead to the occurrence of chronic pulmonary heart disease. However, most drugs for chronic pulmonary heart disease caused by helicobacter pylori are lack of tissue specificity. At the same time, due to the blocked blood circulation in the ischemic area, the distribution of drugs in the ischemic area is often not ideal. The gastroscope technology of nano carbon can make the drug release in the focus as much as possible, and can achieve the goal of targeted treatment. This paper mainly studies the application of the gastroscope technology based on nano carbon in the remedy of chronic pulmonary heart disease caused by helicobacter pylori. After 8 weeks of treatment, the indexes of right heart function in the two groups: TAPSE and RVMPI were better than before treatment, and the improvement degree in the remedy group was more obvious than that in the control group (P < 0.05). The improvement degree of E/A and PASP was not statistically significant, the difference between the two groups was not significant (P > 0.05). In addition, the gastroscope of nano carbon can also reduce UA and TG in blood. The overall response rate was 93.75% in the remedy group, which was higher than that in the control group (P < 0.05).


Subject(s)
Gastritis , Helicobacter Infections , Helicobacter pylori , Pulmonary Heart Disease , Carbon , Gastroscopy , Helicobacter Infections/drug therapy , Humans
2.
J Leukoc Biol ; 108(2): 547-557, 2020 08.
Article in English | MEDLINE | ID: mdl-32248572

ABSTRACT

Traditional Chinese medicine assigns individuals into different categories called "constitutions" to help guide the clinical treatment according to subjective physiologic, psychologic analyses, large-scale clinical observations, and epidemiologic studies. To further explore more objective expressions of constitutions, antibody microarrays were used to analyze the serologic protein profiles of two different constitutions, a balanced (or healthy) constitution (BC) and the dampness constitution (DC) comprising phlegm-dampness and damp-heat constitutions. The profiles of changing constitutions across time were also analyzed. Nineteen differentially expressed proteins between the two groups were identified, with known biologic functions involved in immunity and inflammation. This proteomic study may provide a biologic explanation why the BC is different than the dampness constitution.


Subject(s)
Blood Proteins , Medicine, Chinese Traditional , Proteome , Proteomics , Biomarkers , Computational Biology/methods , Female , Humans , Male , Medicine, Chinese Traditional/methods , Proteomics/methods , ROC Curve
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