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Fitoterapia ; 146: 104733, 2020 Oct.
Article in English | MEDLINE | ID: mdl-32979464

ABSTRACT

Chenopodium album Linn is used as the traditional Chinese medicine for treating cough, anorexia, piles, dysentery, diarrhea, and kills small worms in China. Nine new tropolones (1-9), and fourteen known tropolone derivatives (10-23) were elucidated by comprehensive spectroscopic data analysis and references from C. album Linn for the first time. Compounds (1-4) and compounds (13-14) displayed notably hepatoprotective activities in intro for lowering AST levels (19.63 ± 2.34 to 29.87 ± 1.27 U•L-1) and ALT levels (15.21 ± 1.18 to 20.29 ± 2.11 U•L-1) in HepG2 cells treated with H2O2. Compounds (8-9) and compounds (15-17) exhibited moderate antiproliferative activities in vitro against the human tumor cell lines with IC50 values ranging from 0.5 ± 0.2 to 15.5 ± 2.7 µM. A preliminary structure activity relationship was summarized and discussed scientifically, which provided new clues to design novel hepatoprotective and antiproliferative drugs based on the tropolone derivatives.


Subject(s)
Antineoplastic Agents, Phytogenic/pharmacology , Chenopodium album/chemistry , Protective Agents/pharmacology , Tropolone/pharmacology , Antineoplastic Agents, Phytogenic/isolation & purification , Cell Line, Tumor , China , Drugs, Chinese Herbal , Hep G2 Cells , Humans , Molecular Structure , Phytochemicals/isolation & purification , Phytochemicals/pharmacology , Plant Components, Aerial/chemistry , Protective Agents/isolation & purification , Structure-Activity Relationship , Tropolone/isolation & purification
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