ABSTRACT
Some fertility patients with polycystic ovary syndrome (PCOS) undergoing controlled ovarian hyperstimulation (COH) experience ceased follicular growth during COH and fail to superovulate. In this article, 24 such PCOS patients resumed COH 15-20 days after previous COH treatment was stopped while patients were under ovarian downregulation. Seventeen cases achieved oocyte retrieval, of which 14 underwent embryo transfer and 12 resulted in clinical pregnancy. The remaining seven cases saw ceased follicular growth at 13 mm. This provides a rescue protocol for failed COH patients with PCOS.
Subject(s)
Ovulation Induction , Polycystic Ovary Syndrome , Adult , Embryo Transfer , Female , Fertilization in Vitro , Gonadotropins/administration & dosage , Gonadotropins/therapeutic use , Humans , Infertility, Female/therapy , Ovarian Follicle/physiology , Ovulation Induction/adverse effects , Ovulation Induction/statistics & numerical data , Pelvic Inflammatory Disease , Treatment Failure , Young AdultABSTRACT
The success rate of human embryonic stem cell (hESC) derivation depends on both culture conditions and embryo quality and is routinely determined by morphological criteria. However, high incidence of chromosomal abnormality even in high-grade cleavage embryos from in vitro fertilization (IVF) patients suggests that the morphological grade of supernumerary embryos obtained from IVF clinics may not be a good prediction factor for successful hESC derivation. We show here that from one donor under identical derivation conditions 12 karyotypically abnormal post-bioptic embryos did not yield hESC lines, whereas two out of four normal embryos did. This suggests that the capacity of embryos to give rise to hESC line is likely to be influenced by their genetic status.
