Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi ; 32(12): 1623-1626, 2016 Dec.
Article in Chinese | MEDLINE | ID: mdl-27916093

ABSTRACT

Objective To study the protective effect of interleukin-22 (IL-22) against the hyperoxia-induced lung injury in neonatal SD rats. Methods The neonatal SD rats were randomized into control group, hyperoxia group and IL-22 (10 ng/g) treatment group. Each group was randomly divided into three subgroups of 1, 3, 7 days (n=9). Body mass in every group was detected; lung pathological changes were observed by HE staining; tumor necrosis factor α (TNF-α) in lung tissues was tested by quantitative real-time PCR; and IL-1ß in plasma was measured by ELISA. Results After exposure to hyperoxia for 1 day, the body mass in the three groups showed no significant difference, and the structure of lung tissues were normal. After exposure to hyperoxia for 3 or 7 days, the body mass in the hyperoxia group was significantly lower, IL-1ß in plasma was significantly enhanced, and the structure of lung tissues were destroyed, which aggravated with the time of hyperoxia exposure. TNF-α mRNA level increased obviously in the hyperoxia group. However, when treated with IL-22, TNF-α mRNA was significantly down-regulated in the treatment group. Conclusion IL-22 may play an protective role in hyperoxia-induced lung injury.


Subject(s)
Hyperoxia/complications , Interleukins/pharmacology , Interleukins/therapeutic use , Lung Injury/drug therapy , Lung Injury/etiology , Animals , Animals, Newborn , Disease Models, Animal , Hyperoxia/metabolism , Interleukin-1beta/blood , RNA, Messenger , Rats , Rats, Sprague-Dawley , Tumor Necrosis Factor-alpha/genetics , Tumor Necrosis Factor-alpha/metabolism , Interleukin-22
SELECTION OF CITATIONS
SEARCH DETAIL
...