ABSTRACT
In older patients involution processes are observed. Frequency of H. pylori infection has been related of histopathological changes of gastric mucosa in patients over 65 yrs old. In 73% of analyzed patients gastritis atrophica has been documented.
Subject(s)
Gastric Mucosa/pathology , Helicobacter Infections/epidemiology , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Female , Helicobacter Infections/microbiology , Helicobacter pylori/isolation & purification , Humans , Male , Middle AgedABSTRACT
The Helicobacter pylori status of the population of Eastern European countries has not been explored despite the high incidence of peptic ulcer disease and gastric cancer observed in these countries. A seroprevalence study has been performed in Wroclaw, a city of Lower Silesia, Poland, to provide insight into this question. Sera were collected to obtain 50 subjects per 5 yr increment of age. A second generation ELISA kit with a high sensitivity and specificity was used. The results plotted by year of birth show a very high prevalence of H. pylori infection in all adults groups born before 1970 (80-100% positive). In the younger age groups, a dramatic decrease was observed. Because it is now known that most H. pylori infections are acquired in childhood (cohort effect), it can be predicted that the infection rate in the adult population will be much lower in the future compared with that presently observed, and it can be expected that evolution in H. pylori prevalence will have an impact on the rate of gastroduodenal diseases in Poland. Because of the high prevalence, it was not possible to identify risk factors for infection in this population.
Subject(s)
Helicobacter Infections/diagnosis , Helicobacter Infections/epidemiology , Helicobacter pylori , Serologic Tests , Adolescent , Adult , Age Distribution , Aged , Aged, 80 and over , Child , Child, Preschool , Enzyme-Linked Immunosorbent Assay , Europe, Eastern , Humans , Infant , Infant, Newborn , Middle Aged , Poland , PrevalenceABSTRACT
In order to find an objective marker of disease intensity, neutrophil elastase activity was determined in patients with ulcerative colitis. The study included 41 patients with ulcerative colitis who were divided into two groups depending on tge stage of the disease on the basis of the activity index according to Maier et al. The obtained results of studies were compared a group of 18 healthy persons. The values of neutrophil elastase activity in the patients and in the control group were subjected to statistical analysis. It was found that neutrophil elastase activity in the patients with high degree of disease intensity was lower than that in the patients with low degree of disease intensity and in healthy subjects. The obtained differences were statistically significant. From the results of the study the conclusion was drawn that the neutrophil elastase activity may be an indicator of ulcerative colitis activity.
Subject(s)
Colitis, Ulcerative/enzymology , Leukocyte Elastase/metabolism , Neutrophils/enzymology , Pancreatic Elastase/metabolism , Adolescent , Adult , Aged , Biomarkers/analysis , Female , Humans , Male , Middle AgedABSTRACT
On the basis of literature and on the grounds of their own experience the authors presented their opinions on the coexistence of colitis ulcerosa (c.u.) and pregnancy. It was stressed that colitis ulcerosa does not decrease fertility in women whereas the taking of salazosulfapyridine diminishes fertility in men. Pregnancy should be planned during the remission period. Successive pregnancies in the same patient with coexistent c.u. should be taken individually. Classic pharmacotherapy end endoscopic diagnostics are not contraindicated in pregnancy. Past operation (e.g. partial or total colectomy) do not decrease chances of giving birth to a child. There is no evidence that artificial abortion exerts a favourable influence on the course of colitis ulcerosa. Cesarean section should be performed of obstetrical indications only. In addition, the authors emphasize the necessity of a strict monitoring of c.u. in the first trimester of pregnancy and during puerperium, as well as of a rigorous gynecological supervision in the third trimester of pregnancy.
Subject(s)
Colitis, Ulcerative/therapy , Pregnancy Complications/therapy , Colitis, Ulcerative/diagnosis , Female , Humans , Pregnancy , Pregnancy Complications/diagnosis , Pregnancy Trimester, First , Pregnancy Trimester, ThirdABSTRACT
The aim of present study was stating the cause of jaundice among patients over 65 years old treated in the medical and surgery departments of two clinics in the years 1985-1987. During the three years 247 cases of jaundice of various etiology excluding virus hepatitis were found. It was stated that the most frequent cause of jaundice in patients over 65 years was cholelithiasis (36.6%). The second subsequent cause was cancer (31%), especially that of gallbladder. Among the group of patients up to 65 years treated in medical departments, the most frequent cause of jaundice was cancer (27.3%) and the subsequent cause was cholelithiasis (21.3%). In the department of surgery, among the younger age group cholelithiasis was the most numerous cause of jaundice. Comparing our own examinations with similar ones undertaken 7 years earlier among patients from Wroclaw, we can state a significant increase of cancer in the population of our town.
Subject(s)
Jaundice/etiology , Adult , Age Factors , Aged , Aged, 80 and over , Female , Humans , Male , Middle AgedABSTRACT
The histoenzymological studies of ATPase and SDH enzymes in rats' gastric mucosa after a single 90 s administration of 96% ethanol proved considerable changes in the enzymes activity in course of injury and subsequent regeneration of mucosa.
