ABSTRACT
Estimation of the severity state in patient, suffering an acute pancreatitis, while admitting him into a hospital, constitutes a significant part of diagnosis and complex treatment. Application of a highly accurate scales and markers, which are used to prognosticate the disease course severity and to determine the inflammation grade, may influence the results of complex treatment of the patients. In the investigation a high diagnostic accuracy in prognosis of an acute pancreatitis course severity was noted for APACHE II scale (24 hours) and Ranson scale (48 hours). There was established, that determination of a C-reactive protein content has less diagnostic accuracy, but it may be applied as a less complex and more rapid test for prognostication of an acute pancreatitis course severity after admitting the patient to hospital.
Subject(s)
C-Reactive Protein/analysis , Pancreatitis, Acute Necrotizing/diagnosis , Severity of Illness Index , APACHE , Adolescent , Adult , Aged , Aged, 80 and over , Female , Hospitalization , Humans , Male , Middle Aged , Pancreatitis, Acute Necrotizing/blood , Pancreatitis, Acute Necrotizing/etiology , Prognosis , Sensitivity and Specificity , Young AdultABSTRACT
62 patients with acute pancreatitis (AP) were examined in order to determine hemocoagulation disorders. The obtained results showed that the patients developed the consumptive coagulopathy with high levels of D-dimer, activation and exhaustion of antithrombin III (AT III). The development of hemocoagulation disturbances in patients with severe AP was confirmed through decrease of activity of AT III up to 68% and high level of D-dimer>693 ng/ml.
Subject(s)
Blood Coagulation Disorders/etiology , Pancreatitis/complications , APACHE , Acute Disease , Adolescent , Adult , Aged , Aged, 80 and over , Antithrombin III/metabolism , Blood Coagulation Disorders/blood , Female , Fibrin Fibrinogen Degradation Products/metabolism , Humans , Male , Middle Aged , Pancreatitis/blood , Young AdultSubject(s)
Exocrine Pancreatic Insufficiency/etiology , Pancreatitis, Acute Necrotizing/complications , Pancreatitis, Acute Necrotizing/surgery , Diabetes Mellitus/diagnosis , Diabetes Mellitus/etiology , Exocrine Pancreatic Insufficiency/diagnosis , Exocrine Pancreatic Insufficiency/prevention & control , Humans , Pancreatectomy , Pancreatic Function Tests , Retrospective Studies , Severity of Illness Index , Time FactorsABSTRACT
Over the period 1998-2001 a total of 78 patients with III to IV stage carcinoma of the pancreas complicated by jaundice underwent symptomatic and palliative operations. In all patients, the diagnosis was verified histologically with the aid of intraoperative fine-needle biopsy, incision biopsy or in the postoperative period marked by appearance of metastases in the liver--by progressive rise in the CA19-9 marker level. In the postoperative period, immunochemotherapy with the drug amitosine was instituted. Median survival of patients came up to more than 8 months. In four patients, median survival was 38 months.
