ABSTRACT
INTRODUCTION: Hypogonadism and inï¬ammato-ry bowel disease (IBD) are often associated. This association may inï¬uence sexual and reproductive function in IBD, including sperm proï¬le and sex steroid hormones. PATIENTS AND METHODS: This study included 59 IBD patients diagnosed with ulcerative colitis type IBD. Anamnesis was carried out regarding the history of the disease, along with a history of rectal bleeding. Evaluation proceeded with sperm and hormone examination if the patient agreed. RESULTS: Progressive motility sperm, immotile sperm, and normal sperm were found to be signiï¬cantly different between the rectal bleeding groups. In grade 3 (more signiï¬cant bleeding) progressive sperm (24.81 ± 5.85, p < 0.0001) and normal sperm (6.33 ± 12.56, p = 0.0003) rates tended to be lower, while immotile sperm tended to be higher (44.48 ± 11.21, p < 0.0001). Testosterone and free testosterone levels were also reported to be signiï¬cantly different between groups, where grade 3 had lower levels 255.9 ± 30.08, p = 0.014 and 4.645 ± 0.5, p = 0.002 respectively. CONCLUSIONS: Our study shows that the degree of rectal bleeding inï¬uences sperm motility and morphology, as well as testosterone and free testosterone levels. These results can concern managing IBD patients to fulï¬ll reproductive health care.