ABSTRACT
We describe the case of a 2-year-old girl showing a pedunculated lesion on the areola of the nipple since birth. Clinical and histological features were consistent with an adnexal polyp of neonatal skin observed beyond the neonatal period.
Subject(s)
Breast Neoplasms/pathology , Neoplasms, Adnexal and Skin Appendage/pathology , Nipples/pathology , Age Factors , Biopsy , Child, Preschool , Female , HumansSubject(s)
Carcinoma, Squamous Cell/pathology , Kidney Transplantation/adverse effects , Porokeratosis/pathology , Skin Neoplasms/pathology , Warts/pathology , Adult , Biopsy, Needle , Carcinoma, Squamous Cell/etiology , Carcinoma, Squamous Cell/surgery , Female , Follow-Up Studies , Humans , Immunohistochemistry , Kidney Failure, Chronic/surgery , Kidney Transplantation/methods , Male , Middle Aged , Porokeratosis/etiology , Porokeratosis/surgery , Risk Assessment , Severity of Illness Index , Skin Diseases/etiology , Skin Diseases/pathology , Skin Diseases/surgery , Skin Neoplasms/etiology , Skin Neoplasms/surgery , Treatment Outcome , Warts/etiology , Warts/surgeryABSTRACT
We describe a child with a 6-month history of onycholysis, subungual hyperkeratosis, and hemorrhages in most of her fingernails and toenails. Nail involvement preceded the identification of osteolytic lesions at the mastoid on a cranial computed tomography scan, which was performed because of repeated episodes of acute otitis media. Some weeks later, a small number of erythematous papules developed over the trunk and face. The diagnosis of Langerhans cell histiocytosis was made by histopathologic examination of bone, skin, and bed and matrix nail biopsies. Response to treatment with vinblastine and prednisone was excellent. Nail changes in Langerhans cell histiocytosis are extremely uncommon, particularly as the presenting manifestation of the disease. The role of nail involvement as an unfavorable prognostic sign is unclear.
