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Ann Diagn Pathol ; 10(5): 283-7, 2006 Oct.
Article in English | MEDLINE | ID: mdl-16979521

ABSTRACT

A left paravertebral mass discovered incidentally on routine examination in a 39-year-old woman is described. Computerized tomography studies revealed a 7 x 6 cm, well circumscribed, noncalcified soft tissue mass with lobular borders abutting the left inferior pulmonary vein and descending aorta. It was not possible to determine the exact anatomic location of the mass based on the imaging studies as both peripheral lung tumors and posterior mediastinal lesions may exhibit the imaging findings described here. At thoracotomy, the mass was seen to be well circumscribed, focally attached to the pleura but without involvement of lung parenchyma, and situated in the left posterior mediastinum. On histological examination, the lesion showed the classical features of myxopapillary ependymoma. Immunohistochemical studies confirmed this impression by demonstrating strong positivity of the tumor cells for S-100 protein, glial fibrillary acidic protein, and CD99 and negative staining with other differentiation markers. A review of the literature with a discussion of the histologic and radiologic differential diagnosis of these lesions is presented.


Subject(s)
Ependymoma/pathology , Mediastinal Neoplasms/pathology , 12E7 Antigen , Adult , Antigens, CD/genetics , Antigens, CD/metabolism , Cell Adhesion Molecules/genetics , Cell Adhesion Molecules/metabolism , Diagnosis, Differential , Ependymoma/diagnosis , Ependymoma/metabolism , Female , Gene Expression Regulation, Neoplastic , Glial Fibrillary Acidic Protein/genetics , Glial Fibrillary Acidic Protein/metabolism , Humans , Mediastinal Neoplasms/diagnosis , Mediastinal Neoplasms/metabolism , S100 Proteins/genetics , S100 Proteins/metabolism , Tomography, X-Ray Computed
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