Validation and adaptation of the Spanish version of the systemic lupus activity questionnaire (S-SLAQ) in an Argentinean population.

OBJECTIVES: To validate the systemic lupus activity questionnaire (SLAQ) in Spanish language. METHODS: The SLAQ questionnaire was translated and adapted in Spanish. Consecutive SLE patients from 8 centers in Argentina were included. A rheumatologist completed a Systemic Lupus Activity Measure (SLAM), Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)-2K, and a physician's assessment. Reliability was assessed by internal consistency (Cronbach's alpha), stability by test-retest reliability (intraclass correlation coefficient), and construct validity by evaluating the correlation with clinically relevant scores. Sensitivity and specificity for clinically significant disease activity (SLEDAI ≥6) of different S-SLAQ cut-off points were evaluated. RESULTS: We included 97 patients ((93% female, mean age: 40 years (SD14.7)). Internal consistency was excellent (Cronbach's alpha = 0.84, p < 0.001), and the intraclass correlation coefficient was 0.95 (p < 0.001). Mean score of S-SLAQ was 8.2 (SD 7.31). Correlation of S-SLAQ was moderate with Patient NRS (r= 0.63 p< 0.001), weak with SLAM-no lab (r = 0.42, p <0.001) and SLAM (r = 0.38, p < 0.0001), and very weak with SLEDAI-2K (r = 0.15, p =0.1394). Using the S-SLAQ cutoff of five points, the sensitivity was 72.2% and specificity was 37.9%, for clinically significant disease activity. CONCLUSIONS: The S-SLAQ showed good validity and reliability. A good correlation, similar to the original instrument, was observed with patient´s global disease activity. No correlation was found between S-SLAQ and gold standard disease activity measures like SLEDAI-2K and SLAM. The S-SLAQ cutoff point of 5 showed a good sensitivity to identify the active SLE population and therefore could be an appropriate screening instrument for disease activity in clinical and epidemiological studies.

Prevalence and incidence of systemic lupus erythematosus in Tucumán, Argentina.

The aim of this study was to determine the prevalence and incidence of Systemic Lupus Erythematosus (SLE) in Tucumán, Argentina. METHODS: The study included inpatient and outpatient charts from four public hospitals and private practice rheumatology clinics, all of them members of the Tucumán Rheumatology Society. Patients older than 16 years with diagnosis of SLE between January 2005 and December 2012 were included. Prevalence and annual incidence were calculated as the number of cases per 100.000 inhabitants during the period 2005 to 2012. RESULTS: Three hundred fifty-three patients were identified. The mean age at diagnosis was 30.5 ± 11.7 years, 93.5% women, 83% mestizos. Prevalence was 24.3 cases/100.000 inhabitants (CI 95% 22.6-28.8) and age-adjusted (≥16 years) of 34.9 cases/100.000 inhabitants (CI 95% 32.8-41.1). The annual incidence in 2005 was 1.8 cases/100.000 inhabitants (95% CI 1-2.9) and 2012 of 4.2 cases/100.000 inhabitants (95% CI 2.9-5.8). Mortality was 9.1%, with infections being the most frequent cause (14/32). CONCLUSION: The prevalence of SLE in the province of Tucumán was 34.9 cases/100.000 inhabitants.

Desorden bronquiolar primario de difícil diagnóstico / Primary bronchiolar disorder difficult to diagnose

Se presenta una paciente de sexo femenino de 25 años de edad, domiciliada en Santiago del Estero, que ingresa por Servicio de Urgencias del Hospital Padilla de Tucumán el 10/01/14. Refiere disnea grado 2-3 MRC de 10 días de evolución aproximadamente; las 48 horas previas al ingreso presentó fiebre (> 38°C) y compromiso del estado general. Consultó primero en su provincia, donde fue medicada con cronopen balsámico (ampicilna, dipirona, guaifenesina) intramuscular por 6 días, sin evolución favorable

Factors associated with disability in patients with rheumatoid arthritis.

OBJECTIVE: Analyze disability determinants in a cohort of Argentine patients with rheumatoid arthritis (RA). MATERIAL AND METHODS: Consecutive patients with RA, according to ACR'87 criteria, were recruited from 6 rheumatology centers. Demographic and socioeconomic data, family history, comorbid diseases, extra-articular manifestations and information about received treatments were provided. Disease activity was assessed using Disease Activity Score 28 (DAS 28) and the Health Assessment Questionnaire (HAQ)-A was used for the functional capacity. Hand and feet radiographs were assessed using Sharp-van der Heijde score. RESULTS: A total of 640 patients with RA were included, of which 85.2% were females. Mean age was 53 years (interquartile range [IQR], 44-62) and mean disease duration was 8 years (IQR, 4-14). DAS 28 mean was 2.72 (IQR, 1.7-3.7) and HAQ-A mean was 0.62 (IQR, 0.13-1.25). Multiple linear regression showed that the main variables associated with disability were DAS 28, radiologic damage and age. Main predictors of functional disability in the multiple logistic regression using severe HAQ (>2) as dependent variable were DAS 28 (OR, 2; P < 0.0001); age (OR, 1; P = 0.008); and structural damage (OR, 1; P = 0.001). CONCLUSIONS: In this population, the disease activity was the variable that showed the highest impact on the physical function. Radiologic damage affected HAQ as the disease progressed.

Eritrosedimentación, leucopenia, linfopenia y anticuerpo anti-DNA nativo en lupus eritematoso sistémico. Asociación con actividad y daño orgánico / Erythrocyte sedimentation rate, leukopenia, lymphopenia and anti-double stranded DNA antibodies in systemic lupus erythematosus. Association with activity and organ damage

Introducción: La eritrosedimentación (VSG), la leucopenia, la linfopeniay los anticuerpos anti-DNA de doble cadena (anti-DNAn), se han asociado con la actividad del lupus eritematoso sistémico (LES). Su relación con el daño acumulado no es clara. Objetivo: Determinar si la elevación de la VSG, la leucopenia, la linfopenia y el anti-DNAn se relacionan con la actividad o el daño acumulado. Métodos: Se revisaron historias clinicas de pacientes con LES de tres centros de reumatología. Se registraron hemograma, VSG, anti DNAny actividad del LES (SLEDAI) en la primera consulta, cada tres a seis meses y en caso de sospecha de activación. Se evaluó daño orgánico (SLICC/ACR), al primero, tercero, quinto y décimo año de seguimiento. Para analizar leucopenia y actividad de LES, se elaboró una escala sin leucopenia (SLEDAI-L). Los pacientes fueron distribuidos en cuatro grupos de acuerdo al promedio de VSG, leucocitos, linfocitos y clasificados como anti-DNAn positivos o negativos. La media del promedio del SLEDAI y del último SLICC/ACR fueron comparadas entre los grupos de VSG, recuento de linfocitos y entre pacientes anti-DNAn positivos o negativos. La media del promedio de SLEDAI-L y del último SLICC/ACR se compararon entre los grupos de leucocitos. Resultados: De 86 pacientes (75 mujeres, edad media 35,5 ± 10,8 años), 60% tuvieron VSG elevada leve, con un promedio de recuento de leucocitos y linfocitos normal de 92% y 65%, respectivamente y 58% fueron anti-DNAn negativo. La comparación de la media del promedio de SLEDAI y el promedio de SLICC/ACR entre los grupos de VSG, recuento de linfocitos y entre pacientes anti-DNAn positivo y negativo no mostró diferencias significativas, de la misma forma que la media de SLEDAI-L y de SLICC/ACR entre los grupos de recuento de leucocitos. Conclusión: El promedio de elevación de VSG, leucopenia y linfopenia y el anti-DNAn no mostraron asociación con la actividad o el daño acumulado por el LES.

Accrual of organ damage over time in Argentine patients with systemic lupus erythematosus: a multi-centre study.

The goals of this study were to ascertain damage in patients with systemic lupus erythematosus (SLE) from five rheumatologic centres in Argentina and to examine overall damage, damage by domain and damage by item within each domain. We performed a retrospective observational study including patients with SLE (ACR 1997 revised and modified criteria) from five rheumatology centres in Argentina. Organ damage was scored using the SLICC/ACR DI (SDI), ascertained at years 1, 2, 5 and 10. Three centres provided information up to the fifth year. Of the 197 patients, 88.3% were women and their mean age was 33.2 years. The mean disease duration and follow-up were 7.6 and 5.3 years, respectively. Damage accrued gradually over time with SDI ranging from 0.52 (+/-1.1) at year 1 up to 2.46 (+/-2.1) at year 10. The renal system was the most involved system, followed by the neuropsychiatric, the cardiovascular and the musculoskeletal systems. Proteinuria, cognitive impairment, pericarditis, avascular necrosis, cataract and alopecia were the predominant items in their respective systems. Systems such as peripheral vascular, pulmonary, gastrointestinal, diabetes, malignancy and premature gonadal failure were not frequent. Overall SDI had a gradual increase over time. Damage in each domain of SDI, except for diabetes, had a similar behaviour. Behaviour of items in each domain varied.

Validation and crosscultural adaptation of an argentine spanish version of the health assessment questionnaire disability index.

BACKGROUND: The Health Assessment Questionnaire (HAQ) is one of the most frequently used instruments to assess functional capacity in activities of daily living. OBJECTIVE: The objective of our study was to determine the reproducibility and validity of an Argentinean version of the HAQ disability index (HAQ-DI) in patients with rheumatoid arthritis (RA). METHODS: Consecutive adult patients with RA from 3 different provinces in Argentina were included. The original English version of the HAQ-DI was translated and adapted into Spanish by 3 rheumatologists and the final version back translated into English by a bilingual person. The reproducibility of the questionnaire was assessed in 30 patients who came for a second visit 3 to 5 days later. The cross-sectional construct validity was assessed by comparing the HAQ with classic parameters of disease activity (number of swollen and tender joints, patient and physician visual analog scale for pain and activity as well as functional class, erythrocyte sedimentation rate, and C-reactive protein. RESULTS: Two hundred patients with RA were included. The reproducibility was r = 0.97 (P = 1 x 10-5); intraitem correlation analysis did not show any redundancy. Correlation between HAQ-A and parameters of disease activity were all significant. A stepwise multiple regression analysis showed that the main variables associated with HAQ-A scores were visual analog scale for pain and duration of morning stiffness. A weak although significant negative correlation was found between the HAQ-A and economic level (r = -0.21, P = 0.03). The median time to complete the questionnaire was 5 minutes and there were no problems with any questions. CONCLUSION: This version of the HAQ-DI would allow for more availability so that Spanish-speaking countries can select the version most suitable to their sociocultural environment.

Prevalence of rheumatoid arthritis in Tucumán, Argentina.

OBJECTIVE: To ascertain the prevalence of rheumatoid arthritis (RA) in Tucumán, Argentina. METHODS: The study was conducted between January 1, 1998, and December 31, 1999, in Tucumán province in northwest Argentina. Outpatient and hospitalization medical records for all patients with RA aged > or = 16 years were reviewed. Diagnosis was by 1987 American College of Rheumatology (ACR) criteria for RA and the population data were based on the 1991 national census. Prevalence rates, with 95% CI, were calculated using the number of San Miguel de Tucumán residents who fulfilled the 1987 ACR criteria for RA as numerator, and the city population aged > or = 16 as denominator. Crude and age-specific prevalence rates were calculated as number of cases/1,000 inhabitants. RESULTS: We identified 695 cases of RA. Sex-specific and overall prevalence rates (per 1,000) were 1.97 (95% CI 1.8-2) for all, 0.6 (95% CI 0.49-0.73) for men, 3.2 (95% CI 2.9-3.5) for women. CONCLUSION: Prevalence of RA is low in residents of Tucumán, Argentina, and comparable with rates observed in epidemiological surveys from Southern European countries.

Enfermedades del tejido conectivo asociadas a la infección por el virus de inmunodeficiencia humana: 10 años de investigación / Connective tissue diseases associated to the infection by human immunodeficiency syndrome: 10 years of investigation

El presente trabajo es el resultado de nuestra investigación acerca de las enfermedades del tejido conectivo durante el curso de la infección por el virus de inmunodeficiencia humana (HIV). Se determinó en forma prospectiva la prevalencia y características de las manifestaciones reumáticas en 101 pacientes infectados por el virus HIV. El sistema musculoesquelético estuvo comprometido en 72 pacientes: astralgias 35, síndrome de Reiter 10, artritis psoriásica 2, polimiositis 2, vasculitis 2. Artritis en 12 pacientes (oligoarticulares 6, monoarticulares 3 y poliarticulares 3), comprometiendo extremidades inferiores, de 1 semana a seis meses de duración y un cuadro de "Síndrome Articular Doloroso" (SAD en 10 pacientes, caracterizado por dolor articular severo e incapacitante, de grandes articulaciones, sin evidencia de sinovitis. Para determinar el mecanismo patogénico de estas manifestaciones estudiamos la incidencia de autoanticuerpos en 49 pacientes infectados por el virus HIV con manifestaciones reumáticas y la presencia del virus HIV y/o sus antígenos en el líquido y la membrana sinovial. Todos fueron negativos para FR, AAN, anti-RNP, anti-Ro, anti-La y anti-DNA. Cuarenta y un pacientes tuvieron incremento de anticuerpos anticardiolipinas y 45 presentaron bajos niveles de complejos inmunes circulantes... (TRUNCADO)(AU)

Enfermedades del tejido conectivo asociadas a la infección por el virus de inmunodeficiencia humana: 10 años de investigación / Connective tissue diseases associated to the infection by human immunodeficiency syndrome: 10 years of investigation

El presente trabajo es el resultado de nuestra investigación acerca de las enfermedades del tejido conectivo durante el curso de la infección por el virus de inmunodeficiencia humana (HIV). Se determinó en forma prospectiva la prevalencia y características de las manifestaciones reumáticas en 101 pacientes infectados por el virus HIV. El sistema musculoesquelético estuvo comprometido en 72 pacientes: astralgias 35, síndrome de Reiter 10, artritis psoriásica 2, polimiositis 2, vasculitis 2. Artritis en 12 pacientes (oligoarticulares 6, monoarticulares 3 y poliarticulares 3), comprometiendo extremidades inferiores, de 1 semana a seis meses de duración y un cuadro de "Síndrome Articular Doloroso" (SAD en 10 pacientes, caracterizado por dolor articular severo e incapacitante, de grandes articulaciones, sin evidencia de sinovitis. Para determinar el mecanismo patogénico de estas manifestaciones estudiamos la incidencia de autoanticuerpos en 49 pacientes infectados por el virus HIV con manifestaciones reumáticas y la presencia del virus HIV y/o sus antígenos en el líquido y la membrana sinovial. Todos fueron negativos para FR, AAN, anti-RNP, anti-Ro, anti-La y anti-DNA. Cuarenta y un pacientes tuvieron incremento de anticuerpos anticardiolipinas y 45 presentaron bajos niveles de complejos inmunes circulantes... (TRUNCADO)