ABSTRACT
THE AIM: To study the influence of perinatal metabolic disorders, metabolism on the choice of mode of artificial lung ventilation in newborns. MATERIALS AND METHODS: The study included 73 neonates with severe respiratory failure, therefore, all children underwent ALV Depending on the mode ofventilation, patients were divided into two groups: group 1 - 33 neonates who were at the beginning of treatment on a ventilator in the SIMV mode, then led to HFO ventilation; group 2 - 40 neonates who underwent only the SIMV The study used following research methods: analysis ofpregnancy anamnestic data; clinical assessment of the newborn's condition at birth including Apgar score (AS) on the 1st minute after birth; registration of changes of mode and parameters of mechanical ventilation: a mathematical calculation of oxygenation index (0I); determination of triglycerides and cholesterol in the central venous blood of newborns in thefirst hours ofpostnatal life and on the 5th day of life Results: At birth the triglycerides level in the blood of newborns is reduced and didn't differ signicantly between the groups. Along with this,. the newborns of 1st group remained impaired oxygen status, severe hypoxia, progressive increase of 01 not resolved in the conventional ventilation, which is an indication to lead the children to HFO ventilation. CONCLUSION: Asphyxia at birth, resistant to therapy, characterized by worsening hypoxemia, impaired lung function oxygenation, the increase of lactate in the blood, deep base deficiency, disorders of the metabolism of triglycerides and cholesterol and high oxygenation index are testimony to the high-frequency oscillatory ventilation. Pathogenetically justified the use of this kind of respiratory theory, not only during RDSN.
