1.
Org Lett
; 12(19): 4368-71, 2010 Oct 01.
Article
in English
| MEDLINE
| ID: mdl-20812675
ABSTRACT
An unprecedented oxidative Prins transformation on phenol derivatives mediated by a hypervalent iodine reagent has been developed. This method allows a rapid access to highly substituted compact systems present in several natural products via a carbon-based addition on an aromatic core. Substitution at each ring position has been demonstrated, enabling synthesis of molecules with up to two contiguous quaternary carbon centers in good yield.