ABSTRACT
A clinico-experimental investigations for the determination of contents of serotonin, histamine, 11-OCS and ACTH in blood as well as excretion of adrenaline and noradrenaline after extensive resection of the intestine are described. It was shown that the dynamics of contents of biologically active substances in the blood depended on the level of resection and terms after operation. Extensive resection of the intestine is followed by inhibition of the sympatho-adrenal system resulting in reduction of noradrenaline in blood and its excretion with increased excretion of adrenaline.
Subject(s)
11-Hydroxycorticosteroids/metabolism , Adrenocorticotropic Hormone/metabolism , Biogenic Monoamines/blood , Intestinal Diseases/surgery , Intestine, Small/surgery , Pituitary-Adrenal System/metabolism , 11-Hydroxycorticosteroids/blood , Adrenocorticotropic Hormone/blood , Animals , Dogs , Epinephrine/blood , Humans , Intestinal Diseases/physiopathology , Norepinephrine/blood , Norepinephrine/deficiency , Postoperative PeriodABSTRACT
A complex clinico-immunological examination of patients subjected to extensive resections of different portions of the intestine was performed. It was established that participation of the immune system in regulation of homeostasis in patients under examination was characterized by lympho- and monocytopenia, lower amount of T-lymphocytes at the expense of low avidity fractions with a simultaneous increase of high avidity fractions of these cells.
Subject(s)
B-Lymphocytes/immunology , Colonic Diseases/surgery , Intestinal Diseases/surgery , Intestine, Small/surgery , Leukopenia/etiology , Monocytes/immunology , T-Lymphocytes/immunology , Animals , Colectomy/methods , Colonic Diseases/immunology , Dogs , Humans , Intestinal Diseases/immunology , Intestine, Small/immunology , Leukocyte CountABSTRACT
Experimentally on 52 dogs and clinically in 46 patients it was found that extensive enterectomy of the distal small intestine, in particular, would induce alterations in the renal function and grave disorders in kalium metabolism. In treatment of patients subjected to extensive enterectomy, it is recommended to use the therapeutic complex contributing not only to rehabilitation of the digestive function but also to normalization of the renal activity and blood water-electrolyte content, special attention being attached to a correction of kalium metabolism.
