ABSTRACT
Technology for minimally invasive approaches to congenital heart disease is a rapidly evolving field. This case report reviews a novel approach to combining two of the newer technologies available to treat a pediatric patient with an atrial septal defect (ASD) and a vascular ring. This report is the first to describe the use of the da Vinci surgical system to assist in a thoracoscopic procedure for a pediatric patient. The da Vinci assisted division of the vascular ring, joined with an Amplatzer closure of the ASD, demonstrates how maximum benefit can be obtained for patients by combining emerging technologies.
Subject(s)
Heart Septal Defects, Atrial/therapy , Prostheses and Implants , Robotics , Thoracoscopy , Child , Echocardiography, Transesophageal , Humans , MaleABSTRACT
Hypoplastic left heart syndrome (HLHS) with a restrictive atrial septal defect (ASD) is a form of congenital heart disease with considerable morbidity and mortality. This morphologic analysis assesses the pulmonary vasculature in this patient population. Pulmonary arteries, the persistence of high-resistance fetal arterioles, pulmonary veins, and lymphatics from multiple lung sections from each of five patients with HLHS and a restrictive ASD were compared to those of five patients with HLHS and nonrestrictive ASD. Lung sections from each patient were qualitatively graded in severity of pathology from 0 to 3 for each of the structures described previously, with the pathologist blinded to the status of the ASD. Patients with a restrictive ASD exhibited more significant pulmonary venous thickening and lymphatic dilatation (p = 0.02), with a tendency toward persistence of high-resistance fetal vessels (p = 0.2), compared to patients with a nonrestrictive ASD. These findings imply that patients with HLHS and a restrictive ASD possess pulmonary vascular abnormalities that place them at higher risk for the current surgical interventions available compared to patients with a nonrestrictive ASD.
Subject(s)
Heart Septal Defects, Atrial/pathology , Hypoplastic Left Heart Syndrome/pathology , Pulmonary Artery/pathology , Pulmonary Veins/pathology , Female , Heart Septal Defects, Atrial/complications , Humans , Hypoplastic Left Heart Syndrome/complications , Infant, Newborn , Lymphatic System/pathology , Male , Retrospective Studies , Vascular ResistanceSubject(s)
Epstein-Barr Virus Infections/diagnosis , Myocardial Ischemia/etiology , Myocarditis/diagnosis , Acute Disease , Adolescent , Electrocardiography , Epstein-Barr Virus Infections/complications , Humans , Male , Myocardial Ischemia/diagnosis , Myocarditis/complications , Myocarditis/virology , Myocardium/enzymologyABSTRACT
High intensity focused ultrasound (HIFU) is an evolving technology with potential therapeutic applications. Utilizing frequencies of 500 kHz to 10 MHz, HIFU causes localized hyperthermia at predictable depths without injuring intervening tissue. Applications in neurosurgery, urology, oncology and, more recently, cardiology for selective cardiac conduction tissue ablation have been promising. A 'noninvasive' technique for causing localized tissue damage to relieve hemodynamic and life-threatening obstruction in patients with congenital cardiac anomalies could replace more invasive procedures. We, therefore, investigated the ability of HIFU to create lesions in mammalian cardiac tissues ex vivo. Porcine valve leaflet, canine pericardium, human newborn atrial septum, and right atrial appendage were studied. Specimens were mounted and immersed in a water bath at room temperature. Using a 1-MHz phased array transducer, ultrasound energy was applied with an acoustic intensity of 1630 W/cm(2) or 2547 W/cm(2) until a visible defect was created (duration 3 to 25 sec). Macroscopic and microscopic examination demonstrated precise defects ranging from 3 to 4 mm in diameter. No damage was identified to the surrounding tissues. Our study concluded that HIFU can create precise defects in different cardiac tissue without damage to the surrounding tissue. Further investigation is needed to assess potential clinical uses of this technology.
Subject(s)
Heart Defects, Congenital/therapy , Pulmonary Valve/pathology , Pulmonary Valve/surgery , Ultrasonic Therapy/methods , Animals , Culture Techniques , Dogs , Heart Septal Defects/therapy , Humans , Infant, Newborn , Sensitivity and Specificity , Swine , Ultrasonic Therapy/instrumentationABSTRACT
A Doppler myocardial performance index, defined as the sum of the isovolumetric contraction and relaxation time divided by the ejection time (ICT + IRT/ET), reflects global cardiac function, and when applied to the left ventricle, may serve as a predictor of moderate rejection in pediatric cardiac transplant patients.
Subject(s)
Graft Rejection/diagnosis , Heart Transplantation/physiology , Postoperative Complications/diagnosis , Ventricular Function, Left/physiology , Adolescent , Biopsy , Child , Child, Preschool , Diastole/physiology , Echocardiography , Female , Graft Rejection/physiopathology , Hemodynamics/physiology , Humans , Male , Myocardium/pathology , Postoperative Complications/physiopathology , Prognosis , Systole/physiologyABSTRACT
BACKGROUND: Invasive techniques such as amniocentesis and cordocentesis are used for diagnosis and treatment in fetuses at risk for anemia due to maternal red-cell alloimmunization. The purpose of our study was to determine the value of noninvasive measurements of the velocity of blood flow in the fetal middle cerebral artery for the diagnosis of fetal anemia. METHODS: We measured the hemoglobin concentration in blood obtained by cordocentesis and also the peak velocity of systolic blood flow in the middle cerebral artery in 111 fetuses at risk for anemia due to maternal red-cell alloimmunization. Peak systolic velocity was measured by Doppler velocimetry. To identify the fetuses with anemia, the hemoglobin values of those at risk were compared with the values in 265 normal fetuses. RESULTS: Fetal hemoglobin concentrations increased with increasing gestational age in the 265 normal fetuses. Among the 111 fetuses at risk for anemia, 41 fetuses did not have anemia; 35 had mild anemia; 4 had moderate anemia; and 31, including 12 with hydrops, had severe anemia. The sensitivity of an increased peak velocity of systolic blood flow in the middle cerebral artery for the prediction of moderate or severe anemia was 100 percent either in the presence or in the absence of hydrops (95 percent confidence interval, 86 to 100 percent for the 23 fetuses without hydrops), with a false positive rate of 12 percent. CONCLUSIONS: In fetuses without hydrops that are at risk because of maternal red-cell alloimmunization, moderate and severe anemia can be detected noninvasively by Doppler ultrasonography on the basis of an increase in the peak velocity of systolic blood flow in the middle cerebral artery.
Subject(s)
Erythroblastosis, Fetal/diagnostic imaging , Middle Cerebral Artery/diagnostic imaging , Ultrasonography, Doppler, Pulsed , Ultrasonography, Prenatal , Blood Flow Velocity , Blood Group Incompatibility/complications , Cordocentesis , Erythroblastosis, Fetal/diagnosis , Erythroblastosis, Fetal/etiology , Erythrocytes/immunology , Female , Fetal Blood/chemistry , Gestational Age , Hemoglobins/analysis , Humans , Infant, Newborn , Isoantibodies/blood , Pregnancy , Pregnancy Complications, Hematologic , Prospective Studies , ROC Curve , Reference Values , Rh Isoimmunization , Sensitivity and SpecificityABSTRACT
Abnormalities of the mitral valve (MV) or the tricuspid valve (TV) morphology and/or function in patients with functional single ventricle may result in early morbidity and death. The purpose of this study was to determine the incidence of contralateral atrioventricular valve (AVV) pathologies in mitral valve atresia (MA) and tricuspid valve atresia (TA). We retrospectively reviewed the echocardiographic data of 50 neonates with MV and 20 with TA. Appearance of the papillary muscles, chordae tendinae, and valve leaflets was assessed. AVV regurgitation was semiquantitated by color-flow Doppler and the AVV annulus diameter was measured and indexed to body surface area. MV abnormalities were found in 9 of 20 (45%) of patients with TA. The MV was myxomatous in 9 patients, the leaflets were redundant in 5 patients, and prolapsing occurred in 4 patients. Mild regurgitation was found in 2 patients. In 18 of 20 (90%) patients MV annulus size was larger than 95% of predicted normal values. TV abnormalities were found in 12 of 50 (24%) patients with MA. The TV was myxomatous in 4 patients, prolapsing in 2, and redundant in 3, and moderate TV regurgitation was found in 3 patients. In 29 of 50 (58%) patients TV annulus size was larger than 95% of predicted normal values. Contralateral AVV abnormalities in tricuspid and mitral valve atresia are common and should be assessed carefully before surgical procedures.
Subject(s)
Mitral Valve/abnormalities , Pulmonary Artery/abnormalities , Tricuspid Atresia/diagnostic imaging , Blood Flow Velocity , Echocardiography, Doppler , Female , Follow-Up Studies , Fontan Procedure , Humans , Infant, Newborn , Male , Mitral Valve/diagnostic imaging , Mitral Valve/surgery , Mitral Valve Insufficiency/diagnostic imaging , Mitral Valve Insufficiency/physiopathology , Mitral Valve Insufficiency/surgery , Pulmonary Artery/diagnostic imaging , Pulmonary Artery/surgery , Retrospective Studies , Tricuspid Atresia/surgery , Tricuspid Valve Insufficiency/diagnostic imaging , Tricuspid Valve Insufficiency/physiopathology , Tricuspid Valve Insufficiency/surgeryABSTRACT
This study is a retrospective review using transthoracic echocardiography to assess the success of fenestration closure as well as residual right to left shunts in 35 patients who underwent Fontan fenestration closure in the catheterization laboratory. There is a high rate of closure of the Fontan fenestration; however, other residual right to left shunts are common.
Subject(s)
Cardiac Catheterization , Echocardiography, Transesophageal , Fontan Procedure , Adolescent , Adult , Child , Child, Preschool , Echocardiography, Doppler, Color , Heart Defects, Congenital/diagnostic imaging , Heart Defects, Congenital/surgery , Heart Septal Defects/diagnostic imaging , Heart Septal Defects/surgery , Heart Ventricles/abnormalities , Humans , Infant , Postoperative Period , Retrospective StudiesABSTRACT
BACKGROUND AND OBJECTIVES: Although survival of patients with the hypoplastic left heart syndrome treated by staged surgical palliation has improved, hemodynamic data after fenestrated Fontan operation and after fenestration closure have not been reported in this patient population. We sought to describe the hemodynamic status of these patients at cardiac catheterization performed for the purpose of fenestration closure and to compare these data with data from contemporary patients with other forms of univentricular heart. METHODS AND RESULTS: Hemodynamic responses to fenestration closure during cardiac catheterization were reviewed in 40 consecutive patients, including 20 with the hypoplastic left heart syndrome and 20 with other forms of univentricular heart defects. Hemodynamics before fenestration closure (arterial saturation and pressure, Fontan baffle saturation and pressure, pulmonary capillary wedge pressure, systemic arteriovenous oxygen content difference, and right-to-left shunt fraction) were nearly identical between the two groups. Significant (p < 0.05) changes after fenestration closure included increases in arterial saturation (9%), mean arterial pressure (3 mm Hg), and baffle pressure (1 mm Hg) and arteriovenous oxygen content difference (18 ml/L), with near elimination of right-to-left shunting. Cardiac output decreased by 21% and systemic oxygen transport by 13%, with no differences between the two patient groups. Mean baffle pressures were <17 mm Hg in 32 patients (80%). CONCLUSIONS: Hemodynamics after fenestrated Fontan operation and responses to fenestration closure in patients with the hypoplastic left heart syndrome were remarkably similar to that in patients with other univentricular heart defects.
Subject(s)
Fontan Procedure , Hemodynamics/physiology , Hypoplastic Left Heart Syndrome/surgery , Postoperative Complications/physiopathology , Adolescent , Blood Pressure/physiology , Cardiac Catheterization , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Hypoplastic Left Heart Syndrome/physiopathology , Male , Oxygen/blood , Reoperation , Treatment OutcomeABSTRACT
The objective of the study was evaluation of the pulmonary venous blood flow (PVF) pattern and the influence of ventricular function and atrioventricular valve regurgitation on this flow in patients with univentricular hearts post total cavo-pulmonary connection (TCPC). Transthoracic or transoesophageal echocardiographic studies were performed in 24 children with normal hearts (group A) and in 24 patients with univentricular hearts (group B). Ventricular function and atrioventricular valve regurgitation was semiquantitatively assessed. Systolic/diastolic maximal velocities and velocity time integrals (VTI) were measured from PVF tracings. Ejection fraction was measured by radionuclide angiography in 11 patients. Twelve patients underwent heart catheterization and angiography. In group B the PVF showed a biphasic flow velocity curve. The systolic integrals were smaller and the diastolic integrals were larger than in group A (6.4 vs. 13.0 cm, P = 0.0001, and 13.9 vs. 10.0 cm, P = 0.005). The pulmonary venous systolic flow fraction in 13 patients with an open fenestration and/or atrioventricular valve regurgitation grade 2-3 was significantly lower than in those 11 patients without fenestration and none/small regurgitation (0.19 vs. 0.40, P = 0.05). In conclusion, the PVF pattern in children with univentricular hearts pallitated with TCPC is similar to the PVF pattern found in individuals with biventricular hearts showing a biphasic flow velocity curve despite the absence of pulsatile pulmonary artery flow. The PVF in patients with TCPC-palliated univentricular hearts is influenced by atrioventricular valve regurgitation and fenestration flow.
Subject(s)
Heart Bypass, Right , Heart Defects, Congenital/physiopathology , Heart Defects, Congenital/surgery , Pulmonary Circulation , Adolescent , Blood Flow Velocity , Child , Child, Preschool , Coronary Angiography , Echocardiography , Follow-Up Studies , Heart Defects, Congenital/diagnostic imaging , Humans , Infant , Pulmonary Veins/physiology , Ventricular Function, RightABSTRACT
BACKGROUND: The purpose of this study was to determine the incidence of moderate to severe tricuspid valve regurgitation in children with hypoplastic left heart syndrome (HLHS) undergoing staged surgical reconstruction, to assess the mechanisms responsible, and to evaluate the efficacy of surgical repair. METHODS AND RESULTS: We retrospectively reviewed clinical and echocardiographic data of 59 consecutive patients with HLHS operated on at our institution. Patients with a moderate or severe degree of tricuspid regurgitation (> or =2+) demonstrated by color flow Doppler echocardiography before the hemi-Fontan or Fontan operation who underwent tricuspid valve repair were included. Patients with HLHS and coexisting atrioventricular septal defect were excluded from the study. Severity of insufficiency was graded on a scale from 1 to 4+ by Doppler color flow mapping. Tricuspid valve morphology, degree of tricuspid valve regurgitation, and right ventricular function were assessed before and after tricuspid valvuloplasty. Eight patients (8/59; 14%) were found to have a minimum of 2+ tricuspid valve regurgitation before hemi-Fontan or Fontan operations. In five of eight patients (62%; Group A), the valve was found to be myxomatous, thickened, and redundant. There were multiple regurgitant jets in three of five (60%) patients in this group. In three of eight patients (37%; Group B), the valve had a normal echocardiographic appearance and regurgitation was the result of a lack of complete leaflet coaptation. All eight patients underwent tricuspid valvuloplasty, and all experienced a decrease in regurgitation. In five of eight (62%) patients, there was a reduction in insufficiency of two grades of severity and in three of eight (37%) patients, there was a one-grade improvement. Tricuspid valve stenosis was not documented in any of the patients after tricuspid valvuloplasty. In seven of eight (87%) patients, right ventricular function was assessed as fair before tricuspid valvuloplasty repair and improved to good in five of seven (71%) patients after the procedure. The remaining patient had good function both at baseline and after tricuspid valvuloplasty. CONCLUSIONS: Moderate to severe tricuspid valve regurgitation is a common finding in patients with HLHS undergoing staged surgical reconstruction and can result from either abnormal valve morphology or incomplete leaflet coaptation. Tricuspid valvuloplasty during either the hemi-Fontan or Fontan stages of reconstruction carries a high success rate and is associated with improved right ventricular function.
Subject(s)
Hypoplastic Left Heart Syndrome/surgery , Tricuspid Valve Insufficiency/surgery , Tricuspid Valve/surgery , Child , Echocardiography , Fontan Procedure , Humans , Retrospective Studies , Tricuspid Valve Insufficiency/etiologyABSTRACT
BACKGROUND: Patients with univentricular hearts and ventriculoarterial discordance with potentially obstructed systemic blood flow continue to pose difficult management problems. The goals of neonatal palliative operations are to control pulmonary blood flow while avoiding pulmonary artery distortion, to relieve systemic outflow tract obstruction, and to avoid heart block. METHODS: Between January 1987 and December 1996, 38 patients with either tricuspid atresia or a double-inlet left ventricle and ventriculoarterial discordance underwent a modified Norwood procedure. Their mean age was 15 days, and their mean weight was 3.4 kg. Aortic arch anomalies were present in 92% of the patients. Morbidity and mortality statistics, intraoperative data, and postoperative echocardiograms were reviewed. RESULTS: There were 3 early deaths (7.8%) and 5 late deaths (13.1%). The actuarial survival rates at 1 month, 1 year, and 5 years were 89%, 82%, and 71%, respectively. Follow-up was complete in all children at a mean interval of 30 +/- 9 months. None of the patients had significant neoaortic valve insufficiency, and 1 patient required therapy for residual aortic arch obstruction. Nine patients (30% of the survivors) have undergone the hemi-Fontan procedure, and 18 patients (60%) successfully have undergone the Fontan procedure. CONCLUSIONS: In this patient population, we recommend the modified Norwood procedure as the neonatal palliative treatment of choice. It can be performed with acceptable early morbidity and mortality, and it improves suitability for the Fontan procedure. It reliably relieves all levels of systemic outflow tract obstruction, controls pulmonary blood flow, and avoids heart block.
Subject(s)
Abnormalities, Multiple/surgery , Aorta/surgery , Heart Ventricles/abnormalities , Palliative Care , Tricuspid Atresia/surgery , Abnormalities, Multiple/mortality , Actuarial Analysis , Aorta/abnormalities , Cardiac Surgical Procedures/methods , Heart Defects, Congenital/mortality , Heart Defects, Congenital/surgery , Heart Ventricles/surgery , Humans , Infant , Infant, Newborn , Survival RateABSTRACT
Transcatheter closure of patent ductus arteriosus with Gianturco coils may impinge on adjacent vascular structures. The left pulmonary artery relative size may decrease after patent ductus arteriosus coil occlusion; thus, serial follow-up echocardiography is recommended to assess long-term left pulmonary artery growth.
Subject(s)
Ductus Arteriosus, Patent/therapy , Embolization, Therapeutic , Pulmonary Artery/diagnostic imaging , Adolescent , Angiography , Blood Flow Velocity , Child , Child, Preschool , Ductus Arteriosus, Patent/diagnosis , Ductus Arteriosus, Patent/physiopathology , Echocardiography, Doppler , Female , Follow-Up Studies , Humans , Infant , Male , Pulmonary Artery/physiopathologyABSTRACT
In a canine puppy model, pulmonary artery stenosis was created by banding the left pulmonary artery to 30-40% of its original diameter. Animals underwent right heart catheterization and angiography 1-2 mo later, and Palmaz P308 stents were implanted. Stent redilation was performed 3-5 mo later. One mo postredilation, the animals were restudied and sacrificed. Coarctations of the aorta were created by transverse aortic incision and longitudinal repair. P308 stent implantation was performed 2-3 mo later. Stent redilation was performed after 6-10 mo, and the animals were restudied and sacrificed 1-2 mo later. Stent implantation was performed in 6 puppies with pulmonary artery stenosis, as 2 animals developed postoperative pulmonary arterial hypoplasia, precluding stenting. The stenosis diameter increased from 4.8 +/- 0.5 mm to 7.4 +/- 0.6 mm (mean +/- SE) following stenting (P = 0.005), and increased further to 9.2 +/- 0.7 mm following redilation (P < 0.001). There were no significant vessel tears or ruptures. Coarctation stenting was performed in 8 animals. The coarctation was dilated from 5.8 +/- 0.9 mm to 9.8 +/- 0.6 mm (P < 0.001), and to 13.5 +/- 0.5 mm at redilation (P = 0.002). Redilation could not be performed in 1 animal. Aortic rupture and death occurred in 2 of 7 animals at redilation. Stent implantation and redilation in experimental pulmonary artery stenosis appears safe and effective. Though stent implantation for coarctation of the aorta appears safe, there was a 28% aortic rupture rate at stent redilation in this model.
Subject(s)
Angioplasty, Balloon , Aortic Coarctation/therapy , Arterial Occlusive Diseases/therapy , Pulmonary Artery , Stents , Animals , Aortic Coarctation/diagnostic imaging , Aortic Coarctation/pathology , Arterial Occlusive Diseases/diagnostic imaging , Cardiac Catheterization , Dogs , Pulmonary Artery/diagnostic imaging , Pulmonary Artery/pathology , Radiography , RecurrenceABSTRACT
PURPOSE: The purpose of this report is to describe the MR findings of aortic vegetations in two patients. METHOD: MR imaging using SE and fast GE (Fastcard) sequences was performed in the axial and coronal planes. RESULTS: The vegetations were not visible with SE MRI, but were clearly visible with fast GE imaging (Fastcard). The vegetations appeared as areas of low signal at valve leaflets in contrast to the bright flowing blood. CONCLUSION: MR evaluation in patients with infective endocarditis is useful in clarifying echocardiographic findings and establishing the diagnosis in previously undiagnosed patients.
Subject(s)
Aortic Valve/pathology , Endocarditis/diagnosis , Magnetic Resonance Imaging , Adult , Child, Preschool , Endocarditis, Bacterial/diagnosis , Heart Valve Diseases/diagnosis , Humans , MaleABSTRACT
OBJECTIVE: We sought to determine the prevalence and fate of residual ductal shunting following coil occlusion of patent ductus arteriosus. BACKGROUND: Although transcatheter coil occlusion of patent ductus arteriosus has gained popularity, few follow-up data have been reported. METHODS: A review of 75 patients who underwent coil occlusion was performed. Residual shunting was investigated by Doppler echocardiography in follow-up. Angiograms were reviewed to obtain minimal ductal diameter and ductal angiographic type. RESULTS: Residual shunts were found in 31 patients (41%) on the day of the procedure, and of these, spontaneous closure was noted in 17 (55%) at 2 weeks to 20 months of follow-up. Of the 75 patients studied, 5 (7%) required a second coil procedure, and 10 (13%) remained with persistent residual shunts at most recent follow-up. Actuarial analysis estimated a 6 +/- 5% prevalence of residual shunts 20 months after a single coil procedure and 3 +/- 3% after all coil procedures. Minimal ductal diameter was associated with immediate complete ductal occlusion by a single coil. These patients had significantly smaller (p = 0.003) minimal ductal diameters (1.2 +/- 0.7 mm) than those who required two coils during their initial procedure to achieve immediate occlusion (1.9 +/- 0.7 mm), those who required a second coil procedure (2.0 +/- 0.9 mm), those who had spontaneous closure of residual shunts (1.9 +/- 0.7 mm) and those with persistent residual shunts (2.0 +/- 0.9 mm). No association was identified between ductal angiographic type and outcome of coil occlusion. No late adverse clinical events of coil occlusion or evidence of recanalization was found. CONCLUSIONS: Small residual shunts are common after coil embolization of patent ductus arteriosus, but most close spontaneously. Actuarial analysis estimates complete closure in 94% at 20 months, and reintervention was required in only 7% of patients.
Subject(s)
Ductus Arteriosus, Patent/therapy , Embolization, Therapeutic , Actuarial Analysis , Child, Preschool , Ductus Arteriosus, Patent/diagnosis , Ductus Arteriosus, Patent/epidemiology , Echocardiography, Doppler, Color , Follow-Up Studies , Humans , Prevalence , Time Factors , Treatment OutcomeABSTRACT
Doppler estimation of RV dP/dt correlates well with micromanometer catheter-measured values in children with hypoplastic left heart syndrome. Doppler estimation of RV dP/dt is a method of quantifying RV systolic function independent of geometric assumptions, and may be a valuable method for longitudinal analysis of RV function.
Subject(s)
Cardiac Catheterization , Hypoplastic Left Heart Syndrome/diagnostic imaging , Hypoplastic Left Heart Syndrome/physiopathology , Ventricular Function, Right/physiology , Blood Pressure/physiology , Child, Preschool , Humans , Infant , UltrasonographyABSTRACT
The last decade saw a dramatic change in the management of congenital heart defects. The introduction and development in echocardiography and Doppler modalities enable definitive diagnosis of congenital lesions without cardiac catheterization. At the same time, new therapeutic procedures for congenital defects using the catheter as a channel for different procedures were developed. These therapeutic procedures have replaced cardiac surgery in many types of defects. The new developments in echocardiography and Doppler modalities provide accurate imaging and visualization of the transcatheter devices and brought these two imaging modalities into a close marriage. The use of echocardiography and Doppler in the catheterization laboratory became a must, especially when used in atrial (ASD) and ventricular septal defect (VSD) closure. In this article we will detail the role of echocardiography in the different transcatheter interventional procedures in the catheterization laboratory. Those include atrial septostomy, blade atrial septectomy, balloon dilation, ASD closure, VSD closure, patent ductus anterior closure, and pericardiocentesis.
Subject(s)
Cardiac Catheterization , Echocardiography, Transesophageal , Heart Defects, Congenital/diagnostic imaging , Catheterization , Child , Heart Defects, Congenital/surgery , HumansABSTRACT
We investigated whether Doppler measurement of the fetal middle cerebral artery peak systolic velocity can be used to detect fetal anemia in pregnancies complicated by maternal blood group immunization. We first studied normal values for the middle cerebral artery peak systolic velocity in 135 fetuses (Group A), and also in 23 fetuses at risk for anemia who underwent 56 cordocenteses to assess the fetal hematocrit (Group B). A test to detect fetal anemia, based on the middle cerebral artery peak systolic velocity, was developed by using the data of the fetuses of Group A and Group B. Successively, the middle cerebral artery peak systolic velocity was prospectively determined in 16 fetuses at risk for anemia who underwent 42 cordocenteses (Group C) to assess the test developed, in a multicenter prospective fashion, by using the data of Group A and Group B. In the normal fetuses an exponential model expressed the increase of the middle cerebral artery peak systolic velocity values with advancing gestation. By using the data of the fetuses of Group A and Group B, four zones of anemia risk were identified. In Group C, none of the anemic fetuses had the middle cerebral artery peak velocity below the normal mean value, whereas all of the anemic fetuses had the peak velocity above the normal mean. The middle cerebral artery blood velocity increases with advancing gestation and is a non-invasive method of detecting anemia in pregnancies complicated by maternal blood group immunization.