Subject(s)
Graft Rejection/prevention & control , Graft Survival , Immunosuppressive Agents/therapeutic use , Kidney Transplantation/immunology , Mycophenolic Acid/analogs & derivatives , Adrenal Cortex Hormones/therapeutic use , Creatinine/blood , Cyclosporine/blood , Cyclosporine/therapeutic use , Double-Blind Method , Drug Therapy, Combination , Follow-Up Studies , Humans , Kidney Transplantation/mortality , Kidney Transplantation/physiology , Mycophenolic Acid/therapeutic use , Survival Rate , Time Factors , Transplantation, HomologousSubject(s)
Glucuronates/blood , Glucuronates/therapeutic use , Immunosuppressive Agents/blood , Immunosuppressive Agents/therapeutic use , Kidney Transplantation/immunology , Mycophenolic Acid/blood , Mycophenolic Acid/therapeutic use , Body Weight , Double-Blind Method , Europe , Glucuronates/pharmacokinetics , Humans , Immunosuppressive Agents/pharmacokinetics , Mycophenolic Acid/pharmacokinetics , Regression Analysis , Time FactorsABSTRACT
Cortical bone remodeling rates for rib samples from three archaeological populations and a modern autopsy sample were determined using an algorithm developed by Frost (Frost [1987a] Calcif. Tissue Res. 3:211-237). When plotted against the relative antiquities for population samples, histomorphometric variables; i.e., activation frequency (mu rc), net bone formation (netVf,r,t), and mean annual bone formation rate (Vf,r,t), exhibit a concordant trend of increased cortical bone remodeling activity levels over time. Two intensive foraging populations, Windover and Gibson, are similar for all bone remodeling parameters and have the lowest remodeling activity levels among the samples. The more recent Ledders sample, which is reported to practice agricultural subsistence, is consistently intermediate between these and a modern autopsy sample. Although there appear to be differences in bone formation rates among the populations it is concluded that these differences cannot be attributed to differences in bone remodeling rates among the populations, but rather are reflecting different effective ages of adult compacta for their ribs. These findings suggest that the earlier populations, particularly Windsor and Gibson, appear to have reached skeletal maturity at an older age than observed for modern.
Subject(s)
Bone Remodeling/physiology , Bone and Bones/physiology , Algorithms , Anthropology , Bone Development/physiology , Florida , History, Ancient , Humans , Ribs/physiology , Time FactorsABSTRACT
The Mediterranean Sea produces a salty, dense outflow that is strongly modified by entrainment as it first begins to descend the continental slope in the eastern Gulf of Cadiz. The current accelerates to 1.3 meters per second, which raises the internal Froude number above 1, and is intensely turbulent through its full thickness. The outflow loses about half of its density anomaly and roughly doubles its volume transport as it entrains less saline North Atlantic Central water. Within 100 kilometers downstream, the current is turned by the Coriolis force until it flows nearly parallel to topography in a damped geostrophic balance. The mixed Mediterranean outflow continues westward, slowly descending the continental slope until it becomes neutrally buoyant in the thermocline where it becomes an important water mass.