Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Nat Immunol ; 19(12): 1319-1329, 2018 12.
Article in English | MEDLINE | ID: mdl-30397348

ABSTRACT

Many tumors evolve sophisticated strategies to evade the immune system, and these represent major obstacles for efficient antitumor immune responses. Here we explored a molecular mechanism of metabolic communication deployed by highly glycolytic tumors for immunoevasion. In contrast to colon adenocarcinomas, melanomas showed comparatively high glycolytic activity, which resulted in high acidification of the tumor microenvironment. This tumor acidosis induced Gprotein-coupled receptor-dependent expression of the transcriptional repressor ICER in tumor-associated macrophages that led to their functional polarization toward a non-inflammatory phenotype and promoted tumor growth. Collectively, our findings identify a molecular mechanism of metabolic communication between non-lymphoid tissue and the immune system that was exploited by high-glycolytic-rate tumors for evasion of the immune system.


Subject(s)
Adenocarcinoma/immunology , Macrophages/immunology , Melanoma/immunology , Tumor Escape/immunology , Tumor Microenvironment/immunology , Acidosis/immunology , Adenocarcinoma/metabolism , Animals , Colonic Neoplasms/immunology , Colonic Neoplasms/metabolism , Glycolysis/immunology , Humans , Melanoma/metabolism , Mice , Mice, Inbred C57BL , Mice, Transgenic
SELECTION OF CITATIONS
SEARCH DETAIL
...