ABSTRACT
Purpose: To determine the incidence of contralateral eye involvement and retinal detachment in HIV-infected patients with cytomegalovirus retinitis treated with repeated intravitreous ganciclovir.Methods: In a prospective cohort study in Northern Thailand, HIV-infected patients with cytomegalovirus retinitis were treated with antiretroviral therapy and intravitreous ganciclovir injections and followed for 3 months for contralateral cytomegalovirus retinitis and retinal detachment.Results: Of 49 participants with unilateral cytomegalovirus retinitis at enrollment, 7 developed contralateral eye involvement (4.8/100 person-months, 95% CI 1.9-9.8). Of 105 eyes without a retinal detachment at enrollment, 6 developed a retinal detachment (2.0/100 eye-months, 95% CI 0.7-4.3). Baseline clinical factors were not associated with the development of either outcome.Conclusion: Eyes treated with intravitreous ganciclovir experienced retinal detachment at a rate similar to other populations treated with systemic antivirals. The risk of contralateral eye involvement was relatively high during the first 3 months after initial diagnosis despite the institution of antiretroviral therapy.
Subject(s)
AIDS-Related Opportunistic Infections/drug therapy , Antiviral Agents/adverse effects , Cytomegalovirus Retinitis/drug therapy , Ganciclovir/adverse effects , Retinal Detachment/chemically induced , AIDS-Related Opportunistic Infections/diagnosis , Adult , Anti-Retroviral Agents/therapeutic use , Antiretroviral Therapy, Highly Active , CD4 Lymphocyte Count , Cytomegalovirus Retinitis/diagnosis , Female , Functional Laterality , Humans , Intravitreal Injections , Male , Postoperative Complications , Prospective Studies , Retinal Detachment/diagnosis , Risk Factors , Time FactorsABSTRACT
PURPOSE: To determine the characteristics of hospitalized eye injuries in Northern Thailand, a tertiary referral center. METHODS: The medical records of patients who sustained an eye injury and were admitted to the Department of Ophthalmology, Chiang Mai University, Thailand, from February 2015 to February 2016 were retrospectively reviewed. Demographics and characteristics of each injury were collected. RESULTS: A total of 249 injured patients were included, of which 227 (91.2%) were male. There was no significant difference in the mean (standard deviation) age between genders, 39.8 (22.9) years of age for females and 43.8 (17.8) for males (P = 0.43). Most injuries occurred in the workplace (149/249, 59.8%). Nearly similar proportions of the opened globe and closed globe injuries were observed, 121/249 (48.6%) patients and 109/249 (43.8%) patients. A small proportion sustained eyelid/adnexal and chemical injury, 19/249 (7.6%) patients. Corneal penetration (52/249, 20.9%) and intraocular foreign body (37/249 14.9%) were the most prevalent conditions for opened globe injury. Traumatic lens subluxation/dislocation (31/249, 12.4%) and a traumatic corneal ulcer (25/249, 10.1%) were the common conditions for closed globe injury. A delayed presentation to the hospital was noted in closed globe injury. The eyelid/adnexal injury group had a better final visual acuity compared to the opened and closed globe injury group. CONCLUSION: Activities related to hospitalized eye injuries were varied in different age groups, specifically adults at workplace, and children at playground; therefore different strategies should be applied to prevent visual impairments and disabilities in specific high-risk groups.
