ABSTRACT
In this article is presented a case of multiple chromosomal aberrations in a patient with CML accelerated phase. Cytogenetic and molecular cytogenetic studies allowed us to determine the presence of t(9;22)(q34;q11) and to identify additional abnormalities such as t(1;2)(p36;p21), del (6)(q21), +del(8)(q22), del(18)(q21), +der (22), some of which are not typical for this kind of neoplasia. This case is compared with publications of the same cases. Our data suggested that detected changes can be correlated with previous treatment regimens and the influence of these changes on progression of disease is discussed.
Subject(s)
Chromosome Aberrations , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/genetics , Adult , Bone Marrow Cells/pathology , Chromosome Deletion , Humans , In Situ Hybridization, Fluorescence , Karyotyping , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology , Male , Translocation, GeneticABSTRACT
The neutrophilic phagocytic activity (absorption and enzymic bactericidal) is intensified in rubromycosis patients treated with nizoral vs. those administered griseofulvin. it is advisable to combine griseofulvin therapy with biogenic stimulants (pyrogenal, aloe, fiBS, vitreous body).
Subject(s)
Griseofulvin/therapeutic use , Ketoconazole/therapeutic use , Neutrophils/drug effects , Onychomycosis/immunology , Phagocytosis/drug effects , Tinea Pedis/immunology , Biological Products/therapeutic use , Blood Bactericidal Activity/drug effects , Combined Modality Therapy , Foot Dermatoses/drug therapy , Foot Dermatoses/immunology , Hand Dermatoses/drug therapy , Hand Dermatoses/immunology , Humans , Neutrophils/enzymology , Neutrophils/immunology , Onychomycosis/drug therapy , Tinea Pedis/drug therapySubject(s)
Immunoglobulins/analysis , Tinea Pedis/immunology , Tropical Climate , Chronic Disease , Humans , Seasons , UzbekistanABSTRACT
Evoked responses in the dogfish tectum opticum were studied during electrical stimulation of the spinal cord, its dorsal roots and ramus ophthalmicus of the facial nerve. Recordings were obtained from different depth as well as from different points on the tectum surface. Evoked responses could be detected mainly on the contralateral side of the tectum opticum either as slow positive (spinal cord stimulation) or negative-positive (facial stimulation) waves which were preceeded by one or two fast, probably, presynaptic deflections and followed by a very slow low-amplitude negative wave. The evoked responses possessed the properties of tectal postsynaptic responses, being somatotopically distributed on the surface and reversely represented in the inner part of the tectal lamina. Projections of different inputs were widely overlapped, but specific areas of maximal activity were presented. These findings evidence that the tectum opticum performs a double function: a primary projecting and an integrative centre.
