ABSTRACT
PURPOSE OF THE STUDY: To analyze a correlation between sino-atrial node automatic activity and atrio-ventricular conductivity in patients with lower acute myocardial infarction (AMI) and atrio-ventricular blockade II-III (AVB) during infusion therapy. MATERIALS AND METHODS: Retrospective analysis of care for patients with AMI and AVB was carried out. Infusion therapy effects were studied in 12 patients with right coronary artery disease and AVB. RESULTS: Infusion therapy in patients with lower acute myocardial infarction, atrio-ventricular blockade and right ventricular failure corrects haemodynamic and dromotropic disturbances. Systolic arterial pressure (SAP) increased to 100,4 mmHg (9,9) after infusion of 400 mLin comparison with SAP after infusion of 200 mL (p = 0.003), Diastolic arterial pressure (DAP) increased to 58,7 mmHg (6,8) in comparison with DAP after infusion of 200 mL (p = 0.011), central venous pressure (CVP) decreased to 12.2 cmH2O (3,7) in comparison with CVP after infusion of 200 mL (p = 0.003). Mode of AVB degree indicator changed t 0O (0;0) (p = 0.028). CONCLUSIONS: Infusion volume therapy should be used for correction of right ventricular failure and disturbances of atrio-ventricular conductivity in case of right ventricular failure absence.
Subject(s)
Atrioventricular Block/therapy , Coronary Vessels/physiopathology , Hemodynamics/physiology , Myocardial Infarction/therapy , Plasma Substitutes/therapeutic use , Ventricular Dysfunction, Right/therapy , Atrioventricular Block/etiology , Atrioventricular Block/physiopathology , Female , Heart Rate/physiology , Humans , Male , Myocardial Infarction/complications , Myocardial Infarction/physiopathology , Plasma Substitutes/administration & dosage , Retrospective Studies , Severity of Illness Index , Treatment Outcome , Ventricular Dysfunction, Right/etiology , Ventricular Dysfunction, Right/physiopathologySubject(s)
Cyclic GMP/therapeutic use , Epinephrine/toxicity , Heart Failure/drug therapy , Acute Disease , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Electrocardiography , Epinephrine/administration & dosage , Heart Failure/chemically induced , Heart Failure/physiopathology , Male , RatsABSTRACT
The chronotropic and inotropic effects of guanosine-5'-monophosphate (5'-GMP) and inosine were investigated in isolated frog hearts. 5'-GMP induced biphasic chronotropic and inotropic responses: positive those were inhibited with propranolol, the negative inotropic response could not be inhibited with atropine. Inosine was able to enhance the positive inotropic response to 5'-GMP.
