ABSTRACT
AIM: To study features of heart disease in patients with alkylosing spondyloarthritis (ASA). MATERIAL AND METHODS: We examined 56 ASA patients. Most of the examinees had spinal problems, moderate activity, x-ray sacroileitis stage III. RESULTS: Pulmonary hypertension was detected in 60.7%, right ventricular (RV) hypertrophy--in 37.5%, RV dilation--in 30.4% patients. Interventricular septum, left ventricular posterior wall were thickened (p < 0.05). Left ventricular diastolic dysfunction was registered in 18.2% ASA patients. The changes correlated with the disease duration, spinal lesion, especially of thoracic part. CONCLUSION: Pulmonary hypertension is a frequent finding in ASA patients. Echocardiography (ECG) is highly informative in detection of pulmonary hypertension and right heart disorders in ASA patients. ECG is a screening method in diagnosis of pulmonary hypertension in ASA patients.
Subject(s)
Heart Ventricles/pathology , Hypertension, Pulmonary/diagnostic imaging , Hypertrophy, Right Ventricular/diagnostic imaging , Spondylitis, Ankylosing/complications , Adolescent , Adult , Dilatation, Pathologic/diagnostic imaging , Female , Heart Ventricles/diagnostic imaging , Humans , Hypertension, Pulmonary/etiology , Hypertrophy, Right Ventricular/etiology , Male , Middle Aged , UltrasonographyABSTRACT
In alcohol intoxication proteins and lipoproteins were altered both in human and mice blood and myocardium. Besides the species independent response towards alcoholic intoxication a series of specific alterations, related to species characteristics of the animal were found.
