ABSTRACT
On the basis of clinico-genealogical investigation of the population of some small villages in the ravine Bartang--the isolate in high-montane region--the following indices of frequency of some psychiatric disorders were determined: olygophrenia--3,96; epilepsy--5,09; schizophrenia--6,78 for a 1000 of population. These indices do not differ significantly from those for other regions of the USSR. The favourable evolution of epilepsy and schizophrenia and the absence of genetic froms of olygophrenia were marked.
Subject(s)
Consanguinity , Epilepsy/genetics , Intellectual Disability/genetics , Schizophrenia/genetics , Epilepsy/epidemiology , Humans , Intellectual Disability/epidemiology , Schizophrenia/epidemiology , TajikistanABSTRACT
The authors conducted a dermatoglyphical study of 278 schizophrenic children and adolescents. The frequency of papillary pattern dysplasia of the hands was 23.7% in boys and 22.8% in girls. These data significantly exceed similar indices in normal children and adolescents (377 cases). A clinico-statistical analysis of 62 patients with dysplasia depicted (as a control, a group of 451 patients not differentiated for dysplasia were studied) an earlier onset of the schizophrenic process mainly with psychopath-like disorders and a continuous progressive development.
Subject(s)
Dermatoglyphics , Schizophrenia, Childhood/genetics , Adolescent , Child , Female , Humans , MaleABSTRACT
The paper deals with the distribution of genetic markers (systems ABO, MN, Rh (D), Hp, PTC) and a number of demographic (folding of arms, hand clasping, tongue rolling, right- and left-handedness, of the type of ear lobe, of the types of dermatoglyphic patterns) in the inhabitants of 6 villages in the Mezen District of the Archangelsk Region of the RSFSR (river Peosa basin). The data presented in this work were obtained in the course of examination of over 800 persons. Differences in the interpretation of the results of generally adopted methods of statistical analysis of samples from small populations are discussed. Among the systems analysed in one third of all the cases there was a statistically significant deviation from Hardy-Weinberg's ratios. For the MN blood groups and haptoglobins this was caused by the excess of heterozygotes. The test of Hardy--Weinberg's ratios at the level of two-loci phenotypes revealed no statistically significant deviations either in separate villages or in all the villages taken together. The analysis of heterogeneity with respect to markers inherited according to Mendel's law revealed statistically significant differences between villages in all the systems except haptoglobins. A considerable heterogeneity in the distribution of family names, the frequencies of some of them varying from village to village from 0 to 90%. Statistically significant differences between villages were shown for all the anthropogenetic characters except arm folding, hand clasping and right-left-handedness. Considering the uniformity of the environmental pressure in the region examined, the heterogeneity of the population studied is apparently associated with a random genetic differentiation (genetic drift) and, possibly, with the effect of the progenitor.