1.
J Am Soc Nephrol
; 23(2): 204-7, 2012 Feb.
Article
in English
| MEDLINE
| ID: mdl-22223876
ABSTRACT
Maintenance of metabolic alkalosis generated by chloride depletion is often attributed to volume contraction. In balance and clearance studies in rats and humans, we showed that chloride repletion in the face of persisting alkali loading, volume contraction, and potassium and sodium depletion completely corrects alkalosis by a renal mechanism. Nephron segment studies strongly suggest the corrective response is orchestrated in the collecting duct, which has several transporters integral to acid-base regulation, the most important of which is pendrin, a luminal Cl/HCO(3)(-) exchanger. Chloride depletion alkalosis should replace the notion of contraction alkalosis.
Subject(s)
Alkalosis/etiology , Chlorides/metabolism , Aldosterone/physiology , Alkalosis/therapy , Animals , Bicarbonates/metabolism , Extracellular Fluid/metabolism , Humans , Hydrogen-Ion Concentration , Kidney/metabolism , Rats
2.
Ann Intern Med
; 154(2): 142-3; discussion 143-4; author reply 144, 2011 Jan 18.
Article
in English
| MEDLINE
| ID: mdl-21242383
Subject(s)
American Recovery and Reinvestment Act , Clinical Medicine/trends , Health Care Reform/legislation & jurisprudence , Insurance, Health/legislation & jurisprudence , Clinical Medicine/organization & administration , Clinical Medicine/standards , Editorial Policies , Forecasting , Humans , Periodicals as Topic/standards , United States
3.
Trans Am Clin Climatol Assoc
; 118: 1-22, 2007.
Article
in English
| MEDLINE
| ID: mdl-18528486
Subject(s)
Hypertension/etiology , Sodium Chloride, Dietary/adverse effects , Animals , Blood Pressure , Diet, Sodium-Restricted , Female , Humans , Hypertension/diet therapy , Hypertension/physiopathology , Kidney/physiopathology , Kidney Transplantation/physiology , Male , Public Policy , United States
4.
Trans Am Clin Climatol Assoc
; 118: lxxv-lxxviii, 2007.
Article
in English
| MEDLINE
| ID: mdl-18540126