[Phylogenetic analysis of yeast genes with large stereospecific anomalies in their promoter region]. / Filogeneticheskii analiz genov drozhzhei, imeiushchikh krupnye stereospetsificheskie anomalii v promotornoi oblasti.

Using an original computer program, we analysed 3 yeast Saccharomyces cerevisiae genes that contain large stereospecific anomalies (SA) in their promoter regions. Homologous genes for higher eukaryotic organisms contain large SA either in the same promoter regions or in one of their introns, the involved dinucleotide and DNA helical repeat being often conserved. We suppose that both promoter and enhancer-like sequences for these genes are evolutionary related and/or are regulated by related proteins.

[Stereospecific DNA anomalies in the human chromosome 21]. / Stereospetsificheskie anomalii v strukture DNK 21-i khromosomy cheloveka.

Using our own original computer program, we analysed more than 10 millions b.p. of the complete nucleotide sequence in the human chromosome 21. A graphic catalogue of largest stereospecific anomalies of this sequence is presented. Clusters of different stereospecific anomalies, showing presumably areas of cooperative binding of different regulatory and structural proteins to DNA have been revealed. Most of the large stereospecific anomalies are situated in introns, being often accompanied by regions devoid of some specific dinucleotides.

[Stereospecific anomalies in the structure of DNA from chromosomes V, XII, XIII, XIV, XV and XVI of saccharomycetes yeasts]. / Sterospetsificheskie anomalii v strukture DNK V, XII, XIII, XIV, XV i XVI kromosom drozhzhei-sakharomitsetov.

Using an original computer program we analysed complete nucleotide sequences of chromosomes V, XII, XIII, XIV, XV, and XVI in yeast. The full catalogue of 5 highest stereospecific anomalies and of stereospecific anomalies for 5 genes with highest CAI in each chromosome has been presented. Trains of different stereospecific anomalies, possibly showing areas of cooperative binding of different regulatory and structural proteins to DNA, are documented (see: Soidla, Lukina, 1998, 1999). Together with confirming the earlier noticed association between stereospecific anomalies and genes with high expression level (coding mostly proteins of translation machinery of the cell and glycolytic enzymes), here we can also notice an obviously high incidence of transcription apparatus genes being located at (or near) largest stereospecific anomalies. Intracellular transport genes and genes whose products function in the cell nucleus may also be often associated with largest stereospecific anomalies.

[Stereospecific anomalies in DNA structure of Saccharomyces chromosomes IV, VII, VIII, X and XI]. / Stereospetsificheskie anomalii v strukture DNK IV, VII, X i XI khromosom drozhzhei-sakharomitsetov.

Using an original computer program we analysed complete nucleotide sequences of chromosomes IV, VII, VIII, X and XI in yeast. Data about 5 largest stereospecific anomalies in each chromosome are presented together with those for 5 genes with highest CAI in each chromosome. Clusters of different stereospecific anomalies are demonstrated, including trains of not overlapping anomalies, possibly showing areas of cooperative binding of different regulatory and structural proteins to DNA (Soidla, Lukina, 1998). Together with confirming the earlier noticed connection between stereospecific anomalies and genes with high expression level (coding mostly proteins of translation machinery of cell and glycolytic enzymes), here we also noticed an obvious high incidence of transcription apparatus genes being located at (or near) largest stereospecific anomalies.

[Stereospecific anomalies in the structure of five completely sequenced yeast chromosomes]. / Stereospetsificheskie anomalii v strukture piati polnost'iu sekvenirovannykh khromosom drozhzhei.

Using an original computer program we analysed complete nucleotide sequences of chromosomes I, II, III, VI and IX in yeast cells. As a general rule, we found large stereospecific anomalies near genes with a presumed high expression level (a full catalogue of such anomalies for 5 genes with highest CAI in each chromosome is presented). As a rule, they are also present at mobile genetic elements. Many large stereospecific anomalies are situated next to the sites of specific anomalies of general nucleotide composition-regions devoid of specific dinucleotides. We have noticed many "trains" (lines) of different stereospecific anomalies, possibly showing areas of cooperative binding of different regulatory and structural proteins to DNA. In several, but not all, analysed chromosomes we found a new class of especially large stereospecific anomalies related to repetitive DNA of small length (less than or around 100 nucleotides).