ABSTRACT
Antagonistic properties of the strain Bacillus subtilis IB-54 with respect to dermatophyte fungi Trichophyton rubrum, T. mentagrophytes var. gypseum, Microsporum canis was studied. The studied strains of bacilli effectively inhibited growth and development of dermatophytes when were cultivated on the media containing different carbon sources. Experiments on laboratory animals showed that B. subtilis IB-54 displayed no virulence, toxicity, and toxigenicity and can be considered as perspective object for development of antimycotic drugs.
Subject(s)
Antibiosis , Bacillus subtilis/physiology , Microsporum/growth & development , Trichophyton/growth & development , Animals , Antifungal Agents , Bacillus subtilis/pathogenicity , Culture Media , MiceABSTRACT
New medicinal forms of immunobiological preparations--human lekocytic interferon and bactisporin--have been developed for local application in dentistry, surgery, gynecology. As the basis for these preparations, the pharmacopeial collagen solution has been used. The results obtained in this investigation indicate that the preparations are safe and possess wound-healing properties.
Subject(s)
Bacillus subtilis , Interferons/therapeutic use , Pharmaceutic Aids , Probiotics/therapeutic use , Wounds and Injuries/therapy , Animals , Antibiosis , Bacillus subtilis/physiology , Collagen , Cryopreservation , Drug Evaluation, Preclinical , Humans , Pharmaceutic Aids/chemistryABSTRACT
The results of experiments on rats showed a high healing potential of three collagen-based coating materials containing a combination of biologically active substances including human leukocyte interferon, alfalfa extract, and eubiotic bactisporin. The application of new materials significantly accelerated the healing of model wounds.
Subject(s)
Collagen/pharmacology , Immunologic Factors/pharmacology , Interferons/pharmacology , Plant Preparations/pharmacology , Probiotics/pharmacology , Wound Healing/drug effects , Animals , Bacillus subtilis , Collagen/administration & dosage , Collagen/toxicity , Delayed-Action Preparations , Drug Combinations , Humans , Immunologic Factors/administration & dosage , Immunologic Factors/toxicity , Interferons/administration & dosage , Interferons/toxicity , Mice , Plant Preparations/administration & dosage , Plant Preparations/toxicity , Probiotics/administration & dosage , Probiotics/toxicity , Rabbits , Rats , Species SpecificityABSTRACT
The effect of luceron, a phytopreparation from lucerne (Medicago sativa), was studied with respect to the bile secretion and cholopoietic functions and the bile acid spectrum in the blood of rats. It was found that luceron stimulates the bile secretion activity of hepatocytes and normalizes the synthesis of bile acids in rats with model hepatitis.
Subject(s)
Chemical and Drug Induced Liver Injury/drug therapy , Hepatocytes/drug effects , Medicago sativa , Phytotherapy , Plant Preparations/therapeutic use , Protective Agents/therapeutic use , Animals , Bile/chemistry , Bile/metabolism , Bile Acids and Salts/analysis , Chemical and Drug Induced Liver Injury/etiology , Chemical and Drug Induced Liver Injury/physiopathology , Hepatocytes/metabolism , RatsABSTRACT
A phytopreparation from lucerne (Medicago sativa) was studied with respect to the acute and chronic toxicity and the action upon the cellular genetic mechanism. It was found that the preparation belongs to the group of practically nontoxic properties.
Subject(s)
Medicago sativa/toxicity , Animals , Cells, Cultured , Dogs , Dose-Response Relationship, Drug , Liver/drug effects , Liver/metabolism , Liver/pathology , Mice , Mutagenicity Tests/statistics & numerical data , Ointments , Plant Extracts/toxicity , Rabbits , Rats , Skin Tests/statistics & numerical data , Solutions , Tablets , Teratogens/toxicity , Time FactorsABSTRACT
The effect of eracond on some parameters of immunity and allergic reactions was studied in experiments on mice and guinea pigs. The drug was found to possess an immunomodulating effect.
