[The radioprotective and antioxidant properties of solubilized alpha-tocopherol acetate]. / Radiozashchitnye i antioksidantnye svoistva soliubilizirovannogo al'fa-tokoferola atsetata.

A single intravenous administration of solubilized alpha-tocopherol acetate in a dose of 1 mg/kg to CBA x C57Bl x F1 male mice 3 and 24 hours before radiation was demonstrated to increase 30-day survival rates in the animals. Oily alpha-tocopherol acetate had the identical effects when the agent was intramuscularly given in a dose of 10 mg/kg. There was a rise in peripheral leukocyte counts 0.5 hour after solubilized alpha-tocopherol acetate administration. The antioxidative activity of the solubilized agent was 3.3 times as high as that the routine agent when attacking Tween 80. The higher radioprotective activity of solubilized alpha-tocopherol acetate is accounted for by its enhanced bioavailability, antioxidative activity and effects on the factors of nonspecific body's resistance.

[The content of immunoreactive calmodulin in the blood cells of irradiated animals]. / Soderzhanie immunoreaktivnogo kal'modulina v kletkakh krovi obluchennykh zhivotnykh.

The immunoreactive calmodulin content was shown to increase in the irradiated platelets of rats and cows. Total Ca content did not vary significantly in platelets of exposed animals although there was a tendency toward its increase. At the same time, total Ca content in lymphocytes of irradiated cows increased while the immunoreactive calmodulin level remained unchanged.

[Arterio-venous differences in the vascular and thrombocytic indices of the hemostasis system]. / Arteriovenoznoe razlichie pokazatelei sosudisto-trombotsitarnogo zvena sistemy gemostaza.

Arterio-venous difference in the functional activity of platelets and vascular wall was studied in Wistar rats. It was found that platelets, unlike leukocytes, were functionally more active in arterial than in venous blood. Athrombogenic activity of arteries was higher than that of veins.

[Vascular-platelet link in the hemostatic system of diabetics]. / Sosudisto-trombotsitarnoe zveno sistemy gemostaza bol'nykh sakharnym diabetom.

Activation of the vascular-platelet link of the hemostasis system: an increase in platelet ADP-induced aggregation, the appearance of platelet aggregates in the vascular bed, an increase in the patients' plasma of beta-thromboglobulin concentration, thrombocytic factor 4, a decrease in antiaggregation activity of the vascular wall and sensitifity of patients' platelets to antiaggregation action of acetylsalicylic acid, was found in diabetes mellitus patients. In the authors' opinion, the above changes play a role in disorders of the microcirculation of the organs and tissues and development of complications in these patients.

[Arteriovenous difference in antithrombin III activity and the antiaggregation properties of the vessel wall]. / Arteriovenoznoe razlichie aktivnosti antitrombina III i antiagregatsionnykh svoistv stenki sosudov.

The paper is concerned with the data on the arteriovenous difference in antithrombin III activity and antiaggregation properties of the aortal and inferior vena cava walls in Wistar rats. A correlation between the changes identified and different thromboresistance of the arteries and veins is suggested.

[Effect of ionizing radiation on the functional state of the vascular-thrombocytic component of the hemostasis system]. / Vliianie ioniziruiushchego izlucheniia na funktsional'noe sostoianie sosudisto-trombotsitarnogo zvena sistemy gemostaza.

The influence of ionizing radiation (gamma-rays 60Co) on aggregation activity of the vascular wall and functional (aggregation) platelet activity was studied in the course of the development of acute radiation sickness. The decrease in the aggregation properties of the vascular wall and high functional activity of platelets were inversely proportional, correlating with the periods of acute radiation sickness development and depending on the radiation dose. It is suggested that the changes detected may play a role in the pathogenesis of the development of the postirradiation thrombohemorrhagic syndrome.

[Functional damage of blood vessels and intravascular platelet aggregation in burns]. / Funktsional'nye povrezhdeniia sosudov i vnutrisosudistaia agregatsiia trombotsitov pri ozhogovoi bolezni.

A study was made of the effect of burn injury on aggregation properties of the vascular wall and platelet aggregation capacity. Maximal accumulation of malonic dialdehyde during thrombin-induced aggregation, maximal rise of the spontaneous intravascular platelet aggregation index, and the most remarkable functional lesions of the vascular wall were observed in the early period (within the first hours), at the disease height (day 7), and during the recovery (day 30). Variation of the homestatic balance between the prostacycline- and thromboxane-generating systems of the blood vessels and platelets in the disease early period is linked with stress reaction and release of biologically active substances (adrenaline, cortisone) to the circulation, whereas at the disease height with marked inflammation and emergence in the blood of endotoxin and break down products of cell membrane phospholipids.

[Effect of 60Co gamma rays and fast neutrons on intravascular platelet aggregation and vessel wall prostacyclin activity]. / Vliianaie gamma-luchei 60Co i bystrykh neitronov na vnutrisosudistuiu agregatsiiu trombotsitov i prostatsiklinovuiu aktivnost' stenki sosudov.

The influence of gamma-rays 60Co and fast neutrons on intravascular platelet aggregation and prostacyclin activity of the vascular wall has been studied. It has been shown that 1-6 hours after irradiation of CBA mice, a great number of bone marrow platelets clump to form fibrin fibrils that often close completely the vascular lumen. Experiments with irradiated rats and guinea-pigs have demonstrated the reduction of prostacyclin-like activity in the abdominal aorta wall.

[Platelet dysfunction in diffuse toxic goiter and experimental thyrotoxicosis]. / O narushenii funktsii trombotsitov pri diffuznom toksicheskom zobe i eksperim ntal'nom tiroksinovom toksikoze.

It was shown that in patients suffering from diffuse toxic goitre and in animals with experimental thyroxin toxicosis the platelet aggregation is decreased. Prostaglandin F2 alpha and cGMP restored platelet aggregating ability of patients and experimental animals while cAMP sharply lowered ADP-induced platelet aggregation in patients and animals with thyroxin toxicosis. Acetylsalicylic acid and indomethacin inhibited ADP-induced platelet aggregation approximately equally in patients and in healthy subjects. Thyroxin produced no effect on platelet aggregation in animals previously injected with indomethacin. It was concluded that disturbance of platelet aggregation in patients with diffuse toxic goitre proceeds like thrombopathy A.

[Effect of acetylsalicyclic and nicotinic acids and complamin on the formation of a prostacyclin-like substance by the aortic wall]. / Vliianie atsetilsalitsilovoi, nikotinovoi kislot i komplamina na obrazovanie prostatsiklinopodobnoi substantsii stenkoi aorty.

Experiments on Wistar rats have shown that single oral administration of acetylsalicylic (300 mg/kg), nicotinic (3 mg/kg) acids and complamin (2 mg/kg) inhibits platelet aggregation. It has been established that acetylsalicylic acid inhibits, as an antiaggregation agent, platelet aggregation and synthesis of a prostacycline-like substance by the aortal wall, and decreases its antiaggregation activity. Nicotinic acid and complamin inhibit platelet aggregation but do not lower antiaggregation activity of the aortal wall. Therefore, these latter drugs compare very favorably with acetylsalicylic acid as antiaggregation agents.

[Inhibitory action of adrenaline on the antiaggregation activity of the arterial wall]. / Ingibiruiushchee deistvie adrenalina na antiagregatsionnuiu aktivnost' stenki arterii.

It has been shown in experiments on Wistar rats that adrenaline inhibits both in vitro and in vivo the capacity of the arterial wall for synthesizing an antiaggregating substance (prostacycline). It is suggested that adrenaline takes a direct part in body thrombogenesis during emotional stress and in conditions associated with the increased catecholamine output in the blood.