ABSTRACT
Twenty one patients with the long-term compression syndrome (LCS) and 12 patients with burns treated with sandoglobulin in combination with antibacterial therapy were followed up. The control groups included 14 and 18 patients, respectively. All the patients had wound infections. Increased or lowered respiratory burst of peripheral blood neutrophils and lowered contents of active T-lymphocytes were detected in the majority of the patients. The patients had also an increased respiratory burst of tissue homogenate in the primary focus. Sandoglobulin decreased the periods of normalization of the immunological indices, body temperature and leukogram shifts to the right. The most pronounced effect of the drug was recorded before radical operations, i.e. in the presence of acute microbial toxemia or in patients with severe and extended burns. The procedure of immunological monitoring developed by the authors rapidly estimates the indications to the use of sandoglobulin alone or in combination with other immunomodulators.
Subject(s)
Burns/therapy , Immunoglobulin G/therapeutic use , Shock, Traumatic/therapy , Bacterial Infections/drug therapy , Bacterial Infections/etiology , Body Temperature/drug effects , Burns/complications , Burns/immunology , Colony Count, Microbial , Humans , Immunoglobulins, Intravenous , Leukocyte Count/drug effects , Neutrophils/drug effects , Oxygen Consumption/drug effects , Shock, Traumatic/complications , Shock, Traumatic/immunology , Syndrome , T-Lymphocytes/drug effectsABSTRACT
Addition of immunomodulating therapy with Thymalin, a thymus agent, to the multimodality therapy of burnt patients contributes to a rapid normalization of immunological parameters. The most marked immune response was observed 7-10 days after a therapy course initiated in the early periods of burn disease in patients with severely depressed T-system immunity and a high sensitivity to the drug. Inclusion of a donor blood leukomass transfusion course activates the cellular link of the immune system just after the treatment course, but fails to favour a stable normalization of thymus-dependent lymphocyte ratios.
Subject(s)
Blood Transfusion , Burns/immunology , Lymphopenia/therapy , T-Lymphocytes/immunology , Thymus Hormones/therapeutic use , Adjuvants, Immunologic , Adolescent , Adult , Aged , Burns/therapy , Combined Modality Therapy , Humans , Leukocyte Count , Lymphopenia/etiology , Lymphopenia/immunology , Middle AgedABSTRACT
The condition of the immune system in 56 patients with deep thermal damage was analysed according to the method of treatment; 30 patients were treated by the traditional bandage method, 26 patients--by the open method in bed with an air cushion of the "Klinitron" type. The study showed that the introduction of beds with an air cushion into clinical practice creates the most favorable conditions for the organism's adaptation in extreme functional stress and facilitates earlier normalization of the immune status; increase of the number of "active" T lymphocytes and theophylline-resistant T lymphocytes (helpers), marked reduction of the number of theophylline-sensitive T lymphocytes (suppressors), decrease of the level of circulating immune complexes, and normalization of the immunoglobulin-E content. The positive dynamics of changes of the condition of the immune system occurred during the earlier regeneration processes and when the patients felt better.
