ABSTRACT
Specific features of diffusion in the cerebral corticospinal tract of patients with early stages of schizophrenia were studied using methods of diffusion tensor magnetic-resonance imaging and magnetic resonance spectroscopy. A decrease in the coefficient of fractional anisotropy in the posterior limb of the internal capsule and an increase in diffusion coefficient in the radiate crown and motor cortex were observed. The results reflect different mechanisms of changes in water diffusion in various areas of the corticospinal tract: changes in nerve fiber microstructure in the internal capsule of the left hemisphere and a decrease in their density in the motor cortex and radiate crown.
Subject(s)
Diffusion Tensor Imaging , Pyramidal Tracts/metabolism , Schizophrenia/metabolism , Adolescent , Adult , Anisotropy , Body Water , Cerebral Peduncle/metabolism , Cerebral Peduncle/pathology , Diffusion , Humans , Internal Capsule/metabolism , Internal Capsule/pathology , Male , Medulla Oblongata/metabolism , Medulla Oblongata/pathology , Motor Cortex/metabolism , Motor Cortex/pathology , Nerve Fibers/metabolism , Nerve Fibers/pathology , Pyramidal Tracts/pathology , Schizophrenia/pathology , White Matter/metabolism , White Matter/pathology , Young AdultABSTRACT
Diffusion in the cerebral corpus callosum in patients with early schizophrenia was studied by diffusion tensor MRT and magnetic resonance spectroscopy. The fraction anisotropy coefficient in the corpus callosum knee was low as a result of high radial diffusion. Spectroscopy detected a decrease of N-acetylaspartate level in the corpus callosum knee indicating axonal lesion during the early stage of schizophrenia.
