ABSTRACT
The article contains to forecast risk of toxic effects caused by contemporary household chemicals. The article contains data on evaluating potential risk of health disorders among individuals contacting synthetic detergents and cleansers. The authors summarized experience of Public Health Research center on toxicologic hygienic research of various household chemicals, conducted for safety certification of the end products household application.
Subject(s)
Consumer Product Safety/standards , Dermatitis, Contact/epidemiology , Household Products/adverse effects , Respiratory Tract Diseases/epidemiology , Risk Assessment/methods , Dermatitis, Contact/etiology , Dermatitis, Contact/prevention & control , Humans , Incidence , Prognosis , Respiratory Tract Diseases/chemically induced , Respiratory Tract Diseases/prevention & control , Russia/epidemiology , Safety ManagementABSTRACT
The authors present materials on experimental basis of approximate safe level of exposure to new anti-flu medication Triazavirin in air of workplace. The article covers acute toxicity parameters for various intake routes, results of irritating and sensitizing effects evaluation, determination of threshold concentration for single inhalation effect, value of recommended approximate safe level of exposure.
Subject(s)
Air Pollutants, Occupational/toxicity , Azoles/toxicity , Occupational Diseases/chemically induced , Triazines/toxicity , Animals , Disease Models, Animal , Maximum Tolerated Dose , Mice , Occupational Diseases/diagnosis , Prognosis , Rats , Risk Factors , TriazolesABSTRACT
The authors justify importance of biologic monitoring to increase quality of hygienic control over and diagnosis of occupational disease. The article covers data on international terminology for exposure tests parameters. Although difficult in elaboration, the exposure tests are highly informative and necessary to be put into practice.
Subject(s)
Environmental Monitoring/methods , Occupational Diseases/prevention & control , Occupational Exposure/adverse effects , Poisoning/prevention & control , Humans , Occupational Diseases/diagnosis , Occupational Diseases/etiology , Poisoning/diagnosis , Poisoning/etiology , Risk Assessment/methodsABSTRACT
The article covers main directions of contemporary scientific and practical activities of Industrial Toxicologic Laboratory, that were formulated by the laboratory founder--Honorary Researcher of Russian Federation, Master of Science, Professor N.V. Lazarev--and are followed by his disciples.
Subject(s)
Community Health Services/history , Hygiene/history , Laboratories/history , Toxicology/history , Community Health Services/trends , History, 20th Century , Humans , Laboratories/trends , Research/history , Research/trends , Russia , Toxicology/trendsABSTRACT
The authors necessitate biologic monitoring to be conducted along with chemical monitoring of environmental objects. Accomplishment of biologic monitoring and interpretation of its results are associated with difficulties. Being a valuable addition to chemical monitoring, biologic monitoring is a total chemical dose incorporated by a biologic object.
Subject(s)
Environmental Monitoring/methods , Humans , Occupational Health Services/supply & distributionABSTRACT
The article deals with setting a unified group Maximal Allowable Concentration for inorganic nickel compounds that pollute ambient air in hydro- and pyrometallurgic industries.
Subject(s)
Industry , Nickel/adverse effects , Occupational Diseases/etiology , Occupational Diseases/prevention & control , Occupational Exposure/adverse effects , Catchment Area, Health , Environmental Monitoring/methods , Epidemiological Monitoring , Female , Health Status , Humans , Male , Nickel/urine , Occupational Diseases/mortality , Reference Values , Russia/epidemiology , WorkplaceABSTRACT
The authors present materials on hygienic regulation of such synthetic detergents as "Losk", "Dixan" in air of workplace and populated area, demonstrate results concerning evaluation of "Losk" effects. Discussion covers ways to evaluate chemical load caused by simultaneous emission of synthetic detergents from various environmental objects. For testing reliability of hygienic regulation for complex emission exemplified by "Losk", the authors suggest a model for express evaluation of complex exposure to chemicals.
Subject(s)
Detergents/adverse effects , Occupational Diseases/prevention & control , Occupational Health Services/standards , Air Pollutants/adverse effects , Animals , Chemical Industry , Female , Humans , Pregnancy , RussiaABSTRACT
Experiments on animals were conducted to study influence of following household chemical components included into synthetic washing and cleaning mixtures: anion-active surface active substances, protease Blap 200 G, Savinase 4.OT, Purafect 200 G, alkaline proteinase made in Russia, an aromatic "Magic blue". Surface active substances included into synthetic washing and cleaning mixtures were proved to increase biologic activity of chemical components of the mixtures. Powdered anion-active surface active substances, unlike liquid and paste-like ones, require hygienic regulation in air. All new components of synthetic washing and cleaning mixtures should undergo toxicologic and hygienic examination, and require studies on hygienic regulation, if found in concentrations hazardous for health.
Subject(s)
Household Products/toxicity , Air Pollutants/toxicity , Alkanesulfonic Acids/toxicity , Animals , Benzenesulfonates/toxicity , Dose-Response Relationship, Drug , Endopeptidases/toxicity , Lethal Dose 50 , Maximum Allowable Concentration , Perfume/toxicity , Quaternary Ammonium Compounds/toxicity , Rats , Skin/drug effects , Surface-Active Agents/toxicityABSTRACT
Clinical studies and experiments on laboratory animals covered mechanism of trichloroethylene toxicity. The chemical and its metabolites cause nonspecific toxic effects in membranes and therefore induce energy metabolism disorder that is proved to be a trigger of pathologic process in the intoxication. Experimental studies failed to disclose and explain mechanism of compromised calcium metabolism and its role in cardiac manifestations seen in trichloroethylene poisoning.
Subject(s)
Carbon Tetrachloride Poisoning/etiology , Occupational Diseases/chemically induced , Solvents/poisoning , Trichloroethylene/poisoning , Accidents, Occupational , Acute Disease , Adult , Animals , Carbon Tetrachloride Poisoning/diagnosis , Carbon Tetrachloride Poisoning/therapy , Dose-Response Relationship, Drug , Humans , Kidney/drug effects , Liver/drug effects , Male , Occupational Diseases/diagnosis , Occupational Diseases/therapy , Poisoning/diagnosis , Poisoning/etiology , Poisoning/therapy , Rats , Solvents/toxicity , Trichloroethylene/toxicitySubject(s)
Air Pollutants, Occupational/toxicity , Alkanesulfonic Acids/toxicity , Surface-Active Agents/toxicity , Water Pollutants, Chemical/toxicity , Administration, Oral , Air Pollutants, Occupational/administration & dosage , Alkanesulfonic Acids/administration & dosage , Animals , Lethal Dose 50 , Rats , Surface-Active Agents/administration & dosage , Time Factors , Water Pollutants, Chemical/administration & dosageABSTRACT
The article suggests evaluation of tissue respiration in a pilot experiment, so as to promptly forecast toxicity, jeopardy and reveal metabolic activity and selective effects of industrial poisons.
Subject(s)
Metals/toxicity , Oxygen Consumption/drug effects , Animals , Culture Techniques , Heart/drug effects , Kidney/drug effects , Kidney/metabolism , Lethal Dose 50 , Liver/drug effects , Liver/metabolism , Myocardium/metabolism , RatsABSTRACT
Basing on the results of original clinical and experimental studies, as well as on medical literature data, the contributors proposed a hypothesis of the toxic action of trichloroethylene. It was attempted to prove that the trigger links of trichloroethylene intoxications were the energy exchange disorders caused by the nonspecific membranotoxic actions of the substance's molecules and their metabolites, as well as the extra consumption of energy by the metabolic processing of the poison. Involvement of adaptational reactions, such as the catecholamines' discharge, under the conditions of the damaged metabolic system, decreased the cell's potential and aggravated the severity of intoxications.