ABSTRACT
The third example of anti-Tar and a large Danish pedigree in which Tar antigen is segregating with the Rh haplotype CDTe are reported.
Subject(s)
Antibodies, Anti-Idiotypic/immunology , Blood Group Incompatibility/genetics , Immunoglobulin G/immunology , Rh-Hr Blood-Group System/genetics , Blood Group Incompatibility/immunology , Denmark , Female , Gene Frequency , Humans , Male , Middle Aged , Pedigree , Pregnancy , Rh-Hr Blood-Group System/immunologySubject(s)
Blood Preservation/methods , Blood Platelets , Erythrocytes , Humans , Leukocytes , PlasmaABSTRACT
Antibodies to whole pigeon serum (PS) and pigeon dropping extract (PDE) were investigated in pigeon breeders and controls by an enzyme-linked immunosorbent assay (ELISA). The optimal antigen concentration was in the range of 3-30 microgram protein/ml for both PS and PDE. PDE antibody titres greater than or equal to 10240 were found in three (75%) of four patients with pigeon breeders' disease (PBD) and in 19 (13.6%) of 140 other pigeon breeders (P = 0.011). PS antibody titres greater than or equal to 10240 occurred in all four (100%) PBD patients and in only seven (5.0%) of 140 other breeders (P = 0.0002). In 85 blood donors antibodies in low titres against PS and PDE occurred in 4.7% and 7.1%, respectively. By immunodiffusion three or more precipitin lines were found more often in PBD patients than in other breeders (P = 0.0006), and the highest ELISA antibody titres occurred in patients with precipitating antibodies. No correlation between P blood group phenotypes or anti-P1 antibodies and respiratory symptoms or antibodies to pigeon antigens could be demonstrated.
Subject(s)
Alveolitis, Extrinsic Allergic/immunology , Antibodies/analysis , Bird Fancier's Lung/immunology , Columbidae/immunology , Adolescent , Adult , Aged , Animals , Antigen-Antibody Reactions , Breeding , Cough/immunology , Dyspnea/immunology , Enzyme-Linked Immunosorbent Assay , Female , Humans , Male , Middle Aged , P Blood-Group System/immunologyABSTRACT
Twenty couples suffering from unexplained infertility have been tested in mixed leucocyte culture to determine if the wives were preimmunized against their husbands. The wives were tested against their husbands and four unrelated persons, and thymidine incorporation was measured on the third and fifth days of culture. No evidence was found that would indicate a preimmunization of the wife against her husband as an explanation for their infertility. A slight MLC stimulatory capacity was found in sera from infertile women.
