Subject(s)
Famotidine/therapeutic use , Histamine H2 Antagonists/therapeutic use , Peptic Ulcer/drug therapy , Administration, Oral , Adolescent , Adult , Biopsy , Endoscopy, Digestive System , Famotidine/administration & dosage , Follow-Up Studies , Gastrointestinal Motility/drug effects , Gastrointestinal Motility/physiology , Histamine H2 Antagonists/administration & dosage , Humans , Middle Aged , Peptic Ulcer/pathology , Peptic Ulcer/physiopathology , Remission InductionABSTRACT
A clinical trial has been performed of the food Unipit-3 and Laktanal based on cow milk proteins subjected to enzymic hydrolysis, dia- and ultrafiltration. A preliminary immunochemical assay of the above products protein component and its testing in anaphylactic shock reaction in animals demonstrated low sensitizing activity of this protein. The results of the trial of the above hypoallergenic foods in patients with food allergy showed their good tolerance and therapeutic efficacy.
Subject(s)
Digestive System Diseases/diet therapy , Food Hypersensitivity/diet therapy , Antigen-Antibody Complex/analysis , Dietary Carbohydrates/administration & dosage , Dietary Fats/administration & dosage , Dietary Proteins/administration & dosage , Digestive System Diseases/immunology , Food Hypersensitivity/immunology , HumansABSTRACT
A total of 65 patients with food allergy which manifested primarily by disorders of the gastrointestinal tract, bronchi and skin were placed under observation. The patients were administered sodium chromoglycate (nalcrom) per os in a dose of 200 mg 4 times a day for 2-3 weeks, in part of cases up to 3 months and even up to 1-1.5 year. The skin manifestations of allergy (pruritus, urticaria, Quincke's edema, and eczematous rash), abdominal pain, diarrhea, vomiting, bronchospasm, rhinitis, and conjunctivitis disappeared. At the same time the majority of the patients demonstrated the reduction of the intensity of skin responses to the administration of different food antigens, the decrease of the antibody titer in blood serum in response to food antigens, and of the IgE content in blood. The side effects (nausea, heartburn, intensification of skin itch and abdominal pain) were noted in 4 cases.
Subject(s)
Cromolyn Sodium/administration & dosage , Dermatitis, Atopic/drug therapy , Food Hypersensitivity/drug therapy , Urticaria/drug therapy , Administration, Oral , Adolescent , Adult , Aged , Clinical Trials as Topic , Dermatitis, Atopic/diagnosis , Dermatitis, Atopic/etiology , Female , Food Hypersensitivity/diagnosis , Humans , Male , Middle Aged , Pruritus , Urticaria/diagnosis , Urticaria/etiologyABSTRACT
The total level of IgE was determined in 84 patients with food allergy and in 19 healthy individuals. The level of IgE was significantly elevated in food allergy reflecting a degree of body sensitization. The absence of complete correlation between the clinical signs of disease and the blood level of IgE could depend upon the involvement of IgG-mediated allergic reactions in the pathogenesis of disease. Specific antibodies to ovalbumin of the IgG class were detected in 18 of 25 patients. Certain correlation between a therapeutic clinical effect and the time course of the serum level of IgE was observed.
