[Hormonal balance in women with lung cancer and its changes after combined treatment]. / Gormonal'nyi balans u zhenshchin, bol'nykh rakom legkogo, i ego izmenenie pod vliianiem kombinirovannogo lecheniia.

A relatively more favorable course of lung cancer and higher survival rates observed in female patients than in males make the case for further study of the problem. Endocrine system study group included female lung cancer patients. Blood-ACTH, FSH, LH, STH, T3 and T4 as well as F, 17-CS and estrogen excretion with urine were followed prior to, immediately and long after treatment in 25 menopausal and 11 premenopausal cases (at folliculin phase). Most patients revealed increased levels of free hydrocortisone in blood and urine matched by a lowered excretion of 17-CS. Hyperproduction of ACTH was registered in 40%, whereas 60% showed subnormal concentrations of said hormone. On the average, the levels of estrogens were increased, gonadotropin--decreased, T3--below normal concentrations and T4 and STH--within norm. TTH levels showed a wide-range variation: half that in healthy females-20%, and much higher than in healthy one-65%. Concentration of F was close to normal 15-20 days after surgery while ACTH and 17-CS--after one year. The levels of the other hormones remained virtually unchanged within 1-3 years.

[Hormonal balance characteristics of patients with malignant testicular tumors in relation to the histological type of tumor]. / Osobennosti gormonal'nogo balansa u bol'nykh zlokachestvennymi opukholiami iaichka v zavisimosti ot gistologicheskogo tipa opukholi.

The levels of steroid (17-HOCS, 17-CS and estrogens) and tropic (FSH, LH and ACTH) hormones were assayed and analysed versus histologic pattern and efficacy of combined therapy of tumor in 39 cases of testicular cancer. Decreased level of sex hormones matched by increased concentration of gonadotropins occurred in most patients: marked rise in FSH was observed in seminoma and that in LH--in teratoblastoma and embryonal cancer. Increased levels of 17-HOCS, estradiol, FSH and LH were observed in cases who did not respond to treatment, while lowered concentrations of FSH and LH--in cases of effective treatment. Tropic hormone and 17-HOCS concentrations were registered in cases of relapse.

[Testosterone, epitestosterone and total estrogen excretion in men with cancer of certain localizations]. / Ob ékskretsii testosterona, épitestosterona i total'nykh éstrogenov u muzhchin pri rake nekotorykh lokalizatsii.

To obtain more insight into the problem on the concentration of active androgens in the male organism, the diurnal elimination of testosterone, epitestosterone and estrogens in the urine of male patients with cancer of the lung, urinary bladder, larynx and prostate (321 patients), in stage II--III, was estimated. In patients with cancer of the lung and urinary bladder testosterone was found to be lowered, while total estrogens--lowered or unchanged irrespective of age, a relative hyperestrogenization being noted in them. Contrary, in cancer of the larynx and prostate the male hormones were predominating over female ones (hyperandrogenization). In all the examined patients irrespective of the tumor process localization a relative or even absolute predominance of epitestosterone over testosterone was evident.

[Sex hormone balance in prostate cancer]. / O balanse polovykh gormonov u bol'nykh rakom predstatel'noi zhelezy.

In cancer of the prostatic gland of stage II--III in males, 50--60 years, a reduced gonadial endocrine function is observed, that is manifested in a considerably reduced excretion of testosterone and estrogen. Because of the different rate of reduction in the testosterone and estrogen excretion in patients 50--69 years of age, one may observe the state of relative and in 70--80 years old patients--absolute hyperandrogenization of the organism, which is likely to be an unfavorable factor, taking into account the property of testosterone metabolites (dihydrotestosterone in particular) to enhance proliferative processes in the prostatic gland.

[The effect of synthetic derivatives of testosterone on the activity of acid proteinases, DNA-ase and RNA-ase in the liver and serum of female rats]. / Vliianie sinteticheskikh proizvodnykh testosterona na aktivnost' kislykh proteinaz, DNK-azy i RNK-azy pecheni i syvorotki krovi krys-samok

A study was made of the effect of a 30-day administration of various doses of testosterone-propionate and methyltestosterone to intact female rats given a ration rich in protein on the activity of acid DNA-ase, RNA-ase and proteinases in the liver and the blood serum. The ration itself, rich in proteins, increased the activity of acid RNA in the liver of rats and gave a significant seasonal variations in the activity of RNA-ase and proteinases. Administration of the same doses (1 mg daily) of testosterone-propionate or methyltestosterone produced a different effect on the nuclease metabolism. In the first case there was observed a reduction of the RNA-ase activity, and in the second--of the DNA-ase. Possibly this partially explained a different extent of anabolic properties of these two androgens. An increase in the dose of methyltestosterone to 5 mg, on the contrary, produced activation of RNA-ase in the liver and the blood serum, which could promote the manifestation of catabolic properties.