[Effects of temperature on the open-channel density of delayed rectifier K+ channels in hypothalamic neurons].

AIM AND METHODS: To observe the effect of temperature on multi-order open of delayed rectifier K+ channels in hypothalamic-neurons by cell-attached mode of patch-clamp technique. RESULTS: With temperature raising, the probability of open-channel recording increased, multichannel open occurred. The density of open - channel on membrane of 32 degrees C, 37 degrees C and 39 degrees C was 0.71, 1.22 and 1.82 channels/microm2 respectively (P < 0.05). CONCLUSION: More Ik of hypothalamus opened with temperature raising, this benefited to the body temperature regulation of neurons in hypothalamus.