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1.
Int J Biol Macromol ; 266(Pt 1): 131215, 2024 May.
Article in English | MEDLINE | ID: mdl-38552679

ABSTRACT

Realizing adhesion between wet materials remains challenging because of the interfacial water. Current strategies depend on complicated surface modifications, resulting in limited functions. Herein, a facile strategy based on the powder of grape seed protein and tannic acid (GSP-TA) was reported to endow various non-adhesive hydrogels adhesion without chemical modifications for both hydrogels and adherents. The GSP-TA powder has the capability to absorb interfacial water, form an adhesive layer on the hydrogel surface, diffusion into the underneath hydrogel matrix, and establish the initial adhesion within 5 s. By forming multiple non-covalent interactions between powders and substrates, the GSP-TA powder served as an efficient surface treating agent, enabling robust adhesion to solid substrates (wood, cardboard, glass, iron, and rubber) and wet tissues (pigskin, muscle, liver and heart). The adhesive strength for wood, cardboard, glass, iron, and rubber was 145.92 ± 5.93, 123.93 ± 15.98, 66.24 ± 7.67, 98.22 ± 4.13, and 80.83 ± 7.48 kPa, respectively. Because of reversible interactions, the adhesion was also repeatable. Due to the merits of grape seed protein and plant polyphenol, it could be completely degraded within 11 days. Bearing several merits, this strategy has promising applications in wound patches, tissue repair, and sensors.


Subject(s)
Hydrogels , Polyphenols , Powders , Tannins , Vitis , Tannins/chemistry , Hydrogels/chemistry , Vitis/chemistry , Adhesives/chemistry , Plant Proteins/chemistry , Seeds/chemistry , Animals , Adhesiveness
2.
Carbohydr Polym ; 328: 121738, 2024 Mar 15.
Article in English | MEDLINE | ID: mdl-38220330

ABSTRACT

Developing artificial substitutes that mimic the structures and performances of natural cartilage is of great importance. However, it is challenging to integrate the high strength, excellent biocompatibility, low coefficient of friction, long-term wear resistance, outstanding swelling resistance, and osseointegration potential into one material. Herein, a sandwich hydrogel with cartilage-mimetic structures and performances was prepared to achieve this goal. The precursor hydrogel was obtained by freezing-thawing the mixture of poly vinyl alcohol, chitosan and deionized water three cycles, accompanied by soaking in sodium hyaluronate solution. The top of the precursor hydrogel was hydrophobically modified with lauroyl chloride and then loaded with lecithin, while the bottom was mineralized with hydroxyapatite. Due to the multiple linkages (crystalline domains, hydrogen bonds, and ionic interactions), the compressive stress was 71 MPa. Owing to the synergy of the hydrophobic modification and lecithin, the coefficient of friction was 0.01. Additionally, no wear trace was observed after 50,000 wear cycles. Remarkably, hydroxyapatite enabled the hydrogel osseointegration potential. The swelling ratio of the hydrogel was 0.06 g/g after soaking in simulated synovial fluid for 7 days. Since raw materials were non-toxic, the cell viability was 100 %. All of the above merits make it an ideal material for cartilage replacement.


Subject(s)
Chitosan , Chitosan/chemistry , Hydrogels/pharmacology , Hydrogels/chemistry , Biocompatible Materials/pharmacology , Biocompatible Materials/chemistry , Polyvinyl Alcohol/chemistry , Hyaluronic Acid , Materials Testing , Lecithins , Durapatite/chemistry , Cartilage
3.
Dalton Trans ; 52(15): 4891-4899, 2023 Apr 11.
Article in English | MEDLINE | ID: mdl-36943280

ABSTRACT

Electrocatalyst design is an important approach to prompt the commercialization of water electrolysis technologies. In this work, a ruthenium doped MoS2/AB heterostructure is synthesized as an electrocatalyst for the hydrogen evolution reaction (HER) through hydrothermal and annealing processes. The physical-chemical characterization studies show that the MoS2/AB heterostructure and the incorporation of Ru effectively induce a phase transition from 2H to 1T-MoS2. The as-prepared Ru-MoS2/AB exhibits an excellent HER performance with a very low overpotential of 13 mV at 10 mA cm-2 and a Tafel slope of 31 mV dec-1 in 0.5 M H2SO4, remarkably higher than those of Pt/C (overpotential of 28 mV at 10 mA cm-2, 41 mV dec-1). Density functional theory calculations suggest that the H absorption on Ru bonding to S exhibits a rather low binding energy (-0.22 eV), indicating the optimum active sites of Ru near S for HER. Significantly, the Ru-MoS2/AB also demonstrates high stability under long-term discharge and elevated temperature conditions. These results suggest that the as-prepared Ru-MoS2/AB can be a promising alternative to Pt/C for water electrolysis, due to its high HER activity, easy synthesis, and good stability.

4.
ACS Appl Mater Interfaces ; 14(31): 35434-35443, 2022 Aug 10.
Article in English | MEDLINE | ID: mdl-35913200

ABSTRACT

Designing hydrogels with adequate strength, remarkable swelling resistance, low friction coefficient, excellent biocompatibility, and osseointegration potential is essential for replacing articular cartilage. However, it remains challenging to integrate all these properties into one material. In this work, a Janus hydrogel was prepared from polyvinyl alcohol, chitosan, and sodium hyaluronate, followed by a one-sided dipping in situ precipitation mineralization to form a layer of hybridized hydroxyapatite (HAp), wherein the two surfaces had distinct compositions and functions. Because of the negative carboxyl groups from sodium hyaluronate, the top surface possessed a friction coefficient as low as 0.024. On account of the HAp mineralized layer, the bottom side had osteogenesis potential. Owing to the synergy of physical linkages, the hydrogel displayed compressive strength as high as 78 MPa. Furthermore, it demonstrated remarkable swelling resistance with strength retention near 100% even after soaking in PBS solution at 37 °C for 7 days. The absence of toxic chemicals maintained the merits of starting polymers and resulted in excellent biocompatibility (cell viability ≈ 100%), making it an ideal substitute for articular cartilage.


Subject(s)
Cartilage, Articular , Hydrogels , Compressive Strength , Durapatite , Hyaluronic Acid , Hydrogels/chemistry , Hydrogels/pharmacology , Polyvinyl Alcohol/chemistry
5.
Carbohydr Polym ; 286: 119268, 2022 Jun 15.
Article in English | MEDLINE | ID: mdl-35337498

ABSTRACT

Developing articular cartilage substitutes required a combination of high compressive strength, excellent biocompatibility and low friction. Despite great success in tough hydrogels, this combination was hardly realized. Herein, a high strength, low friction, and biocompatible hydrogel was obtained by freezing-thawing polyvinyl alcohol and chitosan aqueous solutions three times, followed with soaking in sodium alginate aqueous solution. Owing to the synergy of crystalline domains, hydrogen bonds, and ionic interactions, the obtained hydrogel exhibited high strength (maximum compressive strength = 141 MPa). Because of the reversible linkages, the gel was also creep-resistant (recovery efficiency = 93%). Benefitted from the negative carboxyl groups from sodium alginate, the water lubrication layer between the gel and the opposing surface was thickened greatly, resulting in a low coefficient of friction (0.044). The biocompatible materials and green progress led to excellent cell compatibility. All these merits made it an ideal substitute for articular cartilage.


Subject(s)
Cartilage, Articular , Chitosan , Alginates , Biocompatible Materials/chemistry , Chitosan/analysis , Friction , Hydrogels/chemistry , Polyvinyl Alcohol/chemistry
6.
ACS Appl Mater Interfaces ; 14(2): 2638-2649, 2022 Jan 19.
Article in English | MEDLINE | ID: mdl-35045604

ABSTRACT

Fabricating artificial materials that mimic the structures and properties of tendons is of great significance. Possessing a tensile stress of approximately 10.0 MPa and a water content of around 60%, human tendons exhibit excellent mechanical properties to support daily functions. In contrast to tendons, most synthetic hydrogels with similar water content typically exclude qualified strength, swelling resistance, and biocompatibility. Herein, a facile strategy based on poly(vinyl alcohol) (PVA) and tannic acid (TA) is demonstrated to tackle this problem via a combination of sequential steps including freezing-thawing PVA aqueous solutions to form crystalline regions, prestretching and air drying in confined conditions to induce anisotropic structures, soaking in TA solutions to form multiple hydrogen bondings between PVA and TA, and finally dialyzing against water for the removal of residual TA molecules and the rearrangements and homogenization of multiple hydrogen bonds. The obtained PVA hydrogels possess hierarchically anisotropic structures, where the alignment of PVA bundles promotes high modulus, while the hydrogen bonding between PVA and TA endows them with an energy dissipation mechanism. Benefitting from the synergy of material composition and structural engineering, the obtained hydrogel displays super-strong mechanics (a tensile stress of 19.3 MPa and a toughness of 32.1 MJ/m3), outperforming most tough hydrogels. Remarkably, this hydrogel demonstrates excellent swelling resistance. It barely expands after immersion in deionized water, phosphate-buffered saline (PBS), and SBF aqueous solutions for 7 days with the strength and volume nearly the same as their initial values. All of the features, combined with excellent cytocompatibility, make it an ideal material for biotechnological and biomedical applications.


Subject(s)
Biocompatible Materials/chemistry , Hydrogels/chemistry , Tendons/chemistry , Humans , Materials Testing , Tensile Strength
7.
Ultrason Sonochem ; 76: 105632, 2021 Aug.
Article in English | MEDLINE | ID: mdl-34166984

ABSTRACT

A method for degrading organic pollutants in suspension by applying laser-induced cavitation is presented. Cavitation bubbles are produced remotely by laser beams, achieving a purpose of non-contact degradation. In this work, laser-induced bubble dynamics in SiO2 sand suspension were studied by high-speed imaging. Pulsating characteristics of cavitaiton bubbles in the infinite domain and near a solid boundary were investigated among various laser energies and sand concentrations. Furthermore, the extent of degradation after processing in suspension and the mechanism were analyzed. Results indicate that solid particles in the liquid medium reduce the extent of degradation. However, the extent of degradation may rebound at a proper sand concentration. In addition, compared to several small bubbles in a bubble string (in the infinite domain), a single larger bubble (near a solid boundary) has a much higher degradation ability.

8.
Ultrason Sonochem ; 72: 105441, 2021 Apr.
Article in English | MEDLINE | ID: mdl-33385635

ABSTRACT

The mechanism of laser cavitation peening (LCP) including laser shock wave, bubble collapse shock wave, and water-jet was investigated at various stand-off distances (γ) combined with experiment and simulation. The dynamic characteristics, pressure field, and temperature field of cavitation bubble were investigated. The Q235 steel was impacted by LCP and the strengthening mechanism was analyzed, and the chemical effect in LCP was discussed. The results found that the pressure intensity of shock wave and water-jet decreases with increasing the γ. At γ=0, the laser shock wave, bubble collapse shock wave, and water-jet are 989 Mpa, 763 Mpa, and 369 Mpa respectively. The pressure and temperature of the bubble decrease obviously in the second and third pulsations. The impact of LCP causes plastic deformation on the Q235 steel surface and refines the grains on the surface layer within a depth of 20-30 µm. The enhancement of microhardness and the residual stress increases with the increase of γ, and the optimal value for LCPwc is 0.4. The degradation rate of MB solution in the infinite domain, LCPwc, and LCP is 26.4%, 41.7%, and 34.5%.

9.
Ultrason Sonochem ; 68: 105181, 2020 Nov.
Article in English | MEDLINE | ID: mdl-32485625

ABSTRACT

A novel method of laser cavitation (LC) was proposed for degrading organic dye wastewater. Rhodamine B (RhB) aqueous solution was employed as the simulated organic dye wastewater, and a LC system was designed to conduct the experiments of degrading RhB. The effects of laser energy, initial concentration and cavitation time on the degradation were investigated. Moreover, the degradation kinetics, degradation mechanism and energy efficiency were analyzed. The experimental results indicate that RhB aqueous solution can be degraded effectively by LC and the degradation follows the pseudo-first-order kinetics. The extent of degradation increases by 27.6% with the rise of laser energy (50-100 mJ) while it decreases by 7.8% with increasing the initial concentration from (20-40 mg/L), but RhB can not be degraded when exceeding 100 mg/L. The degradation extent of RhB at 100 mJ and 20 mg/L for 3 h is 81.11%, and the RhB solution is almost completely degraded at 150 mJ (98.4%). The degradation velocity of RhB rises firstly and then decreases as the cavitation time increases. The degradation of RhB by LC can be attributed to the N-de-ethylation and chromophore cleavage caused by oxidation of hydroxyl (OH) radical and thermal decomposition. LC has a higher energy efficiency compared with other methods and is more energy efficient at lower laser energy.

10.
ACS Omega ; 4(6): 9932-9938, 2019 Jun 30.
Article in English | MEDLINE | ID: mdl-31460084

ABSTRACT

A novel method whose starting materials was Fe-P waste slag and CO2 using a closed-loop carbon and energy cycle to synthesize LiFePO4/C materials was proposed recently. In the first step, Fe-P slag was calcinated in a CO2 atmosphere to manufacture Fe3(PO4)2, in which the solid products were tested by XRD (X-ray diffraction) analysis and the gaseous products were analyzed by the gas detection method. In the second step, as-synthesized Fe3(PO4)2 was further used as the Fe and P source to manufacture LiFePO4/C materials. Also, the influence of the preparation conditions of Fe3(PO4)2, including calcination time and calcination temperature, on the energy storage properties of as-obtained LiFePO4/C was investigated. It was found that the LiFePO4/C materials, which was synthesized from Fe3(PO4)2 obtained by calcining Fe-P waste slag at 800 °C for 10 h in CO2, exhibited a higher capacity, better reversibility, and lower polarization than other samples. The discharge capacity of as-obtained LiFePO4/C can reach 145 mAh/g at 0.1 C current rate. This work puts forward an environment-friendly method of manufacturing LiFePO4/C cathode materials, which has a closed-loop carbon and energy cycle.

11.
RSC Adv ; 9(56): 32826-32832, 2019 Oct 10.
Article in English | MEDLINE | ID: mdl-35529710

ABSTRACT

Lithium-sulfur (Li-S) batteries are considered to be among the most promising energy storage technologies owing to their high theoretical capacity (1675 mA h g-1). At present, however, discharge mechanisms are complicated and remain a controversial issue. In this work, elemental sulfur, used as an electrical insulator for the cathode, was introduced into batteries for its potential chemical reactions in the electrolyte. A film, prepared by loading elemental sulfur onto glass fiber, was introduced as an interlayer in a Li-S battery. The results demonstrate that elemental sulfur may be reduced to polysulfides even when it functions as an electrical insulator for the cathode. Furthermore, it can improve the overall capacity of the Li-S battery and cycle life. This was verified by simulating the phase equilibrium of the chemical system in Li-S batteries using HSC Chemistry software. We hypothesize that the insulating elemental sulfur could be reduced by polysulfides generated on the cathode, after which they are dissolved in the electrolyte and participate in cathode reactions. This phase transfer effect of sulfur in Li-S batteries revealed a chemical equilibrium in the electrolyte of the Li-S battery, which may form a chemical path embedded into the discharge process of Li-S batteries.

12.
RSC Adv ; 9(62): 36144-36153, 2019 Nov 04.
Article in English | MEDLINE | ID: mdl-35540610

ABSTRACT

In order to effectively destroy the structure of the passive oxidation film that covers zero-valent iron (ZVI), an Fe(iii)-reducing strain, namely Morganella sp., was isolated from anaerobic activated sludge and coated on ZVI, which was distributed in porous ceramsite made of iron dust, kaolin and straw, with a ratio of 7 : 3 : 1. Batch experiments showed that under the optimized conditions, the maximum removal amount of Cr(vi) by ZVI increased from 7.33 mg g-1 to 26.87 mg g-1 in the presence of the Fe(iii)-reducing bacterium. The column experiment was performed with the addition of the agar globules to supply nutrients to the strain. Compared with ZVI, the column penetration time and maximum capture amount of RB-ZVI increased to 17 h and 112.5 mg g-1, respectively, on the 15th day. Furthermore, the service life of RB-ZVI was prolonged in the existence of the strain. Based on X-ray diffraction, Raman spectroscopy and X-ray photoelectron spectroscopy analyses, the key mechanisms for the removal of Cr(vi) by ZVI coated with Fe(iii)-reducing bacterium were determined to be adsorption, reduction, coprecipitation and biomineralization.

13.
ACS Macro Lett ; 6(2): 127-133, 2017 Feb 21.
Article in English | MEDLINE | ID: mdl-35632881

ABSTRACT

While lower critical solution temperature (LCST)-type thermosensitive nanogels have been intensively studied, the upper critical solution temperature (UCST)-type versions are much less explored. This communication reports a method for the synthesis of zwitterionic UCST nanogels by reversible addition-fragmentation chain transfer (RAFT) polymerization-induced self-assembly in water-organic solvent mixtures. The nanogels were prepared by RAFT polymerization of 3-dimethyl(methacryloyloxyethyl)ammonium propanesulfonate, whose polymer is known to exhibit UCST behavior in water, conducted in ethanol-water mixtures at 70 °C using poly(poly(ethylene glycol) methyl ether methacrylate) as a macro-chain transfer agent (CTA) and a difunctional monomer as cross-linker. At a sufficiently high ethanol content in reaction media, spherical hairy nanogels with a single size distribution were obtained. These nanogels exhibited reversible heating-induced swelling and cooling-induced shrinking, consistent with the expected UCST behavior. The hydrodynamic size, volume changing ratio, and transition temperature of nanogels can be tuned by varying ethanol content in solvent mixtures, molar ratio of monomer-to-macro-CTA, and amount of cross-linker. Hairy nanogels were also successfully synthesized using a water-THF mixture as medium. The use of water-organic solvent mixtures as reaction media allowed for facile incorporation of a hydrophobic fluorescent monomer to make functional UCST nanogels.

14.
J Interferon Cytokine Res ; 33(6): 328-34, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23428052

ABSTRACT

Porcine reproductive and respiratory syndrome virus (PRRSV) has caused one of the most economically devastating and pandemic diseases of swine. Previous studies have documented that PRRSV nonstructural protein-1α (nsp1α) was an interferon antagonist, but the mechanism by which nsp1α inhibited the interferon (IFN)-ß production was unclear. Here, by site-directed mutagenesis of the predicted zinc-coordinating residues of the zinc-finger (ZF) domain of nsp1α or by deletion of the ZF domain of nsp1α, we explored whether the ZF domain was required for nsp1α to disrupt the IFN-ß production. The results showed that both mutagenesis of the predicted zinc-coordinating residues of the ZF domain and deletion of the ZF domain made nsp1α lose its interferon antagonism activity. In conclusion, our present work indicated that the ZF domain of nsp1α was necessary for nsp1α to inhibit the IFN-ß induction.


Subject(s)
Interferon-beta/antagonists & inhibitors , Interferon-beta/biosynthesis , Porcine respiratory and reproductive syndrome virus/genetics , Porcine respiratory and reproductive syndrome virus/metabolism , Viral Nonstructural Proteins/genetics , Viral Nonstructural Proteins/metabolism , Zinc Fingers/genetics , Animals , Cell Line , Fibroblasts/metabolism , Haplorhini , Interferon-beta/genetics , Interferon-beta/metabolism , Mutagenesis, Site-Directed/methods , Protein Structure, Tertiary , Zinc/metabolism
15.
Zhonghua Gan Zang Bing Za Zhi ; 19(6): 436-9, 2011 Jun.
Article in Chinese | MEDLINE | ID: mdl-22053374

ABSTRACT

OBJECTIVE: To compare the sensitivities of MALDI-TOF MS and direct PCR sequencing on gene mutations detection of hepatitis B virus. METHODS: 100 serum samples from chronic hepatitis B patients were collected, which consisted of 90 serum samples (study group) from 90 chronic hepatitis B patients received nucleoside analogues (NA) therapy for more than 1 year and HBV DNA titer still higher than 500 copies/ml and 10 serum samples (blank group) from 10 chronic hepatitis B patients never treated with antiviral therapy and HBV-DNA titer higher than 1 x 10(5) copies/ml. 9 known mutations associated with HBV P gene in these samples were detected by MALDI-TOF MS and direct PCR sequencing at the same time, TYPE4.0 software and Sequence Navigator software were used to analyze the results separately. RESULTS: (1) In study group, mutations were detected in 53 samples and the total mutation sites were 86 by MALDI-TOF MS with a positive detection rate of 58.89%, whereas only 19 samples were found with mutations and totally 28 mutation sites were detected by direct PCR sequencing, the positive detection rate was 21.11%. The positive detection rate by MALDI-TOF MS was higher than that by direct PCR sequencing and the difference was statistically significant (P < 0.05). In blank group, no mutations were detected by any method. (2) In study group, when the HBV DNA titers were at 500-1000 copies/ml, 10(3)-10(4) copies/ml and 10(4)-10(5) copies/ml, the positive mutation detection rates by MALDI-TOF MS were 50%, 52.08% and 77.27% respectively, higher than that by direct PCR sequencing, which were only 0%, 8.33% and 45.45%. The difference was still statistically significant (P < 0.05). CONCLUSIONS: MALDI-TOF MS had higher detection sensitivity for known mutation sites as compared to direct PCR sequencing method.


Subject(s)
Drug Resistance, Viral/genetics , Hepatitis B virus/genetics , Polymerase Chain Reaction , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods , DNA Mutational Analysis , Hepatitis B virus/drug effects , Humans , Mutation Rate , Sensitivity and Specificity
16.
Article in Chinese | MEDLINE | ID: mdl-19459513

ABSTRACT

Three hundred and eight mattress dust samples were collected from college dormitories in Shenzhen with a mite prevalence of 88% (271/308). From the samples, 6163 mites were isolated and identified. Dermatophagoides farinae, D. pteronyssinus and Blomia tropicalis were three most abundant species, occupying 29.7%, 21.7% and 17.9%, respectively. It was found that sex of the students, mattress cover (bamboo mat or bed sheet), with or without air conditioner installation, and daily using of air conditioner (<2 h, 2-8 h and >8 h) had no significant influence on the mite prevalence (P>0.05). However, logistic regression analysis revealed that the risk of mite sensitization in male student dormitory was significantly lower than that in female dormitory (OR=0.55, P=0.038), and the risk of using bed sheets was significantly higher than using bamboo mats (OR=2.13, P=0.040). Both mite prevalence and the risk of mite sensitization significantly decreased with higher floor of the dormitory building.


Subject(s)
Beds/parasitology , Dust , Housing , Pyroglyphidae , Animals , China , Female , Male , Universities
17.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 25(2): 487-90, 2008 Apr.
Article in Chinese | MEDLINE | ID: mdl-18610649

ABSTRACT

The host inflammatory reaction is a normal response to injury and the presence of foreign substances. Macrophage is one of the principal cell types in controlling host inflammatory and immune processes; hence, its response to biomaterials has a direct impact on biocompatibility and stability of biomaterials in vivo. This review describes the interaction of macrophages with tissue engineering related biomaterials. The bulk physicochemical structure and surface performance of biomaterials could be designed to control macrophages behaviors (i. e. adhesion, activation, fusion, apoptosis) and host responses, resulting in improving biocompatibility of biomaterials.


Subject(s)
Biocompatible Materials/chemistry , Macrophages/cytology , Macrophages/physiology , Tissue Engineering/methods , Apoptosis/physiology , Biocompatible Materials/metabolism , Cell Adhesion/physiology , Foreign-Body Reaction/immunology , Humans , Inflammation/immunology , Macrophage Activation , Prosthesis Implantation
18.
Int J Radiat Oncol Biol Phys ; 66(4): 1253-62, 2006 Nov 15.
Article in English | MEDLINE | ID: mdl-17145540

ABSTRACT

PURPOSE: The aim of this study was to develop and validate our own benchmark dose-volume histograms (DVHs) of bladder and rectum for both conventional three-dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT), and to evaluate quantitatively the benefits of using IMRT vs. 3D-CRT in treating localized prostate cancer. METHODS AND MATERIALS: During the implementation of IMRT for prostate cancer, our policy was to plan each patient with both 3D-CRT and IMRT. This study included 31 patients with T1b to T2c localized prostate cancer, for whom we completed double-planning using both 3D-CRT and IMRT techniques. The target volumes included prostate, either with or without proximal seminal vesicles. Bladder and rectum DVH data were summarized to obtain an average DVH for each technique and then compared using two-tailed paired t test analysis. RESULTS: For 3D-CRT our bladder doses were as follows: mean 28.8 Gy, v60 16.4%, v70 10.9%; rectal doses were: mean 39.3 Gy, v60 21.8%, v70 13.6%. IMRT plans resulted in similar mean dose values: bladder 26.4 Gy, rectum 34.9 Gy, but lower values of v70 for the bladder (7.8%) and rectum (9.3%). These benchmark DVHs have resulted in a critical evaluation of our 3D-CRT techniques over time. CONCLUSION: Our institution has developed benchmark DVHs for bladder and rectum based on our clinical experience with 3D-CRT and IMRT. We use these standards as well as differences in individual cases to make decisions on whether patients may benefit from IMRT treatment rather than 3D-CRT.


Subject(s)
Algorithms , Decision Support Systems, Clinical , Prostatic Neoplasms/radiotherapy , Radiometry/methods , Radiotherapy Planning, Computer-Assisted/methods , Radiotherapy, Conformal/methods , Adult , Benchmarking/methods , Humans , Male , Radiotherapy Dosage
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