A new concern raised from algal bloom: Organic chloramines in chlorination.

Algal blooms have become a significant challenge in water treatment all over the world. In chlorination of drinking water, algal organic matter (AOM) leads to the formation of organic chloramines. The objectives of this review are to comprehensively summarize and discuss the up-to-date researches on AOM-derived organic chloramines and their chemical activities and toxicity, thereby drawing attention to the potentially chemical and hygienic risks of organic chloramines. The predominant algal species in water sources varied with location and season. AOM from cyanobacteria, green algae, and diatoms are composed of diverse composition. AOM-derived amino acids take a low portion of the precursors of organic chloramines. Both experimental kinetic data and quantum chemical calculation demonstrate the preferential formation of organic chloramines in the chlorination of model compounds (amino acids and peptides). Organic chloramines are persistent in water and can transform into dichloro- and trichloro-organic chloramines, unknown low-molecular-weight organic chloramines, and nitrogenous disinfection byproducts with the excess of free chlorine. The active chlorine (Cl+) in organic chloramines can lead to the formation of chlorinated phenolic compounds. Organic chloramines influence the generation and species of radicals and subsequent products in UV disinfection. Theoretical predictions and toxicological tests suggest that organic chloramines may cause oxidative or toxic pressure to bacteria or cells. Overall, organic chloramines, as one group of high-molecular-weight disinfection byproducts, have relatively long lifetimes, moderate chemical activities, and high hygienic risks to the public. Future perspectives of organic chloramines are suggested in terms of quantitative detection methods, the precursors from various predominant algal species, chemical activities of organic chloramines, and toxicity/impact.

Two-stage injection of polymer and microsand during ballasted flocculation for treating kaolin waters with or without humic acid: Floc evolutional characteristics, performance and mechanisms.

Ballasted flocculation is regarded as a most promising water treatment technology in aspects of retrofit and high-rate applications. To deep understand the incorporation behaviors of ballasting agent into ballasted floc growth, two distinct injection modes (namely a two-stage injection of polyacrylamide (PAM) alone, and a two-stage injection of both PAM and microsand) were developed in this study. Then, ballasted flocculation tests of kaolin and kaolin-HA (humic acid) waters were conducted at varying split ratios for fixed total dosages of both PAM and microsand. The experimental results showed that for either two-stage injection mode, the higher the second percentage of each split ratio, the greater the average size of maturated flocs at the second sub-stage of maturation. Meanwhile, the turbidity and UV254 values of settled water became lower at 30 and 180 s of sedimentation, suggesting that varying split ratios significantly affected the kinetics of ballasted floc growth. Moreover, it was suggested that the selection of either two-stage injection mode or corresponding split ratios played a more pronounced role in the HA removal than the total dosage of PAM. This suggestion was supported by SEM, FTIR and XPS analyses for surface morphological details, functional groups and chemical states of maturated flocs eventually formed in the kaolin-HA water through both two-stage injection modes. Accordingly, newly-established conceptual models of ballasted floc growth were proposed to explore the potential influencing mechanisms of varying split ratios on the ballasted flocculation performance. At each sub-stage of maturation, an appropriate dosage ratio between PAM and microsand was of great importance to effectively incorporate microsand particles into ballasted floc formation, besides the hydrolyzed produces of AS coagulant formed at the coagulation stage of ballasted flocculation. This study is expected to provide valuable insights for making ballasted flocculation more effective, economical and sustainable in water treatment engineering.

Manipulating the processing window of directed self-assembly in contact hole shrinking with binary block copolymer/homopolymer blending.

Directed self-assembly (DSA) lithography has demonstrated significant potential in fabricating integrated circuits. However, DSA encounters limited processing windows due to the requirement for precise matching between the period of block copolymers (BCPs) and graphoepitaxy templates. We propose a binary BCP/homopolymer blending strategy to manipulate the self-assembly behavior and the processing window of graphoepitaxy DSA in contact hole shrinking. By carefully tailoring the blending rates of poly(methyl methacrylate) (PMMA) with different molecular weights in cylindrical polystyrene-b-poly(methyl methacrylate) (PS-b-PMMA), we manipulate the period and morphology of BCP/homopolymer self-assembly. Specifically, we employ BCP/homopolymer blending to fine-tune the critical dimension (CD) of contact holes with PS-affined topographical templates. Subsequent pattern transferring is achieved by selectively etching defect-free shrinkable cylinders as hard masks. Furthermore, self-consistent field theory (SCFT) simulation was employed to explore the self-assembly of BCP/homopolymer blending in confined cylindrical space and the results were in good consistency with the experimental results.

A meta-analysis of the association between mindfulness and motivation.

Introduction: Mindfulness reflects attention to the present moment in a non-judgmental way and has been linked to individual autonomy and motivation, but conclusions are inconsistent. The purpose of this review was to summarize previous studies to explore the relationship between mindfulness and motivation and its intervention effects. Methods: Literature searches were conducted in five electronic databases. Both correlational studies assessing the association between motivation and mindfulness and experimental studies to verify the effect of intervention were included. Results: Six papers with seven intervention studies and twenty-three papers with twenty-seven correlational studies met the inclusion criteria. Meta-analysis showed that mindfulness was positively correlated with intrinsic motivation (r = 0.28, p < 0.0001) and total motivation (r = 0.37, p < 0.0001) but had no significant correlation with extrinsic motivation (r = 0.01, p = 0.93) or amotivation (r = -0.17, p = 0.14). Effect-size estimates suggested that mindfulness intervention was beneficial to motivation promotion, but the effect was at a low level (g = 0.12). Conclusion: We found consistent support for mindfulness practice relating to motivation promotion, especially on intrinsic motivation development. However, there was still a portion of heterogeneity that could not be explained and needed to be identified in future studies.

Comparisons of facial emotion recognition in different social contexts among patients with schizophrenia, major depressive disorder and bipolar disorder.

BACKGROUND: Previous studies have found that patients with schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD) all have facial emotion recognition deficits, but the differences and similarities of these deficits in the three groups of patients under different social interaction situations are not clear. The present study aims to compare the ability of facial emotion recognition in three different conversation situations from a cross-diagnostic perspective. METHODS: Thirty-three participants with SCZ, 35 participants with MDD, and 30 participants with BD were recruited, along with 31 healthy controls. A computer-based task was given to assess the ability of Facial Emotion Categorization (FEC) under three different conversational situations (praise, blame, and inquiry). RESULTS: In the "praise" situation, patients with SCZ, MDD and BD were all slower to recognize anger emotion than the healthy controls. In all three clinical groups, patients with SCZ recognized angry faces faster than those with MDD and BD on a continuum from happy faces to angry faces in the "inquiry" situation, while no significant difference was found in the latter two groups. In addition, no significant defect was found in the percentage and threshold of angry face recognition in all three patient groups. CONCLUSIONS: Our findings indicate that patients with SCZ, MDD, and BD share both common and distinct deficits in facial emotion recognition during social interactions, which may be beneficial for early screening and precise intervention for these mental disorders.

Insight into enhanced degradation of tetracycline over peroxymonosulfate activated via biochar-based nanocomposite: performance and mechanism.

Rice husk biochars (BCs) doped with ferric chloride were prepared by one-pot method, characterized by SEM, EDS, BET, XRD, and FTIR, and utilized to catalyze peroxymonosulfate (PMS) for tetracycline (TC) degradation. Various influencing factors in the BC/PMS/TC system were investigated, as well as the recycling performance of the optimal BC. The mechanism of BC activation of PMS and degradation of TC were analyzed based on the free radicals quenching experiment and the pathways of TC degradation. The results demonstrated that bBC3 was an excellent catalyst with large specific surface area; the amounts of oxidant and catalyst were important factors affecting the catalytic performance of PMS, while pH had less effect on TC degradation; 10 mM of chloride ions inhibited the TC degradation, while 20 mM promoted the TC degradation; other ions and humic acid inhibited the TC degradation at the set concentrations; activation of PMS by bBC3 yielded species with strong oxidative activity, which were primarily responsible for TC degradation. The bBC3 obtained stable performance for removing TC. This study provided a pathway for the deep utilization of waste rice husks besides an effective method for degrading TC.

Activation of peroxymonosulfate by biochar and biochar-based materials for degrading refractory organics in water: a review.

Water pollution caused by refractory organics has attracted widespread concern in recent years. At this time peroxymonofulfate (PMS) has been widely used to generate sulfate radicals with high reactivity and potential. The direct reaction rate between PMS and organics is very low. However, the activated PMS has a strong oxidizing ability on organics due to its conversion into sulfate radicals. Recently, the free radicals generated by oxidant PMS and catalyst biochar have proven to be an effective species in dealing with refractory organics. In order to enable researchers to better understand the current research status of PMS/biochar, and to promote the development and application of PMS/biochar system, we have written this review. This review in detail described the mechanism of PMS activated by biochar materials, and summarized the influencing factors of refractory organics degradation in the PMS/biochar system. In addition, the active sites of PMS/biochar, the degradation mechanism of refractory organics, and the reusability of biochar catalysts were also discussed. Finally, the concluding remarks and perspectives were made for future research on the PMS/biochar system in the degradation of refractory organics.

Protection against acute renal injury by naturally occurring medicines which act through Nrf2 signaling pathway.

The cellular defense pathway plays a key role in maintaining the homeostasis, tissues and organisms. Nuclear factor E2-related factor 2 (Nrf2), as a key cell signaling pathway, plays an important role in encoding detoxification enzymes and other stress response mediators. Recent studies have shown that it is closely related to the prevention and treatment of acute kidney injury (AKI). Therefore, this article reviews the protective effects of Nrf2-related signaling pathways on acute kidney injury, and summarizes the strategies of natural pharmaceutical ingredients such as flavonoids, alkaloids, terpenes, phenylpropionic acid, polyphenols, and polysaccharides to prevent and treat acute kidney injury. It is of great significance to further study the relationship between Nrf2 regulated signal pathway and kidney disease and the development of new medicines for acute kidney injury treatment. It can also provide new ideas and treatment strategies for clinical treatment of acute kidney injury. PRACTICAL APPLICATIONS: This article reviewed the mechanisms by which the active ingredients of natural medicines slow down acute kidney injury through the Nrf2 pathway. It will help us to understand the regulatory role of the Nrf2 pathway in AKI more comprehensively, and provide a theoretical basis for further exploring the mechanism of more natural drugs to reduce acute kidney injury.

Correction of range walk error for underwater photon-counting imaging.

Due to the characteristics of photon-counting LIDAR, there exists range walk error (RWE) when the intensity of the signal fluctuates. In this paper, an effective method to rectify underwater RWE was proposed. The method allows the separation of signal detections from noise detections, and based on a prior model, the method can compensate for RWE. An underwater experiment verified its feasibility and results showed RWE of three parts in a plane was reduced from 75mm to 7mm, from 45mm to 3mm and from 5mm to 0mm, respectively, even when the rate of backscatter photons reached 4.8MHz. The proposed correction method is suitable for high precision underwater photon-counting 3D imaging application, especially when the signal intensity varies sharply.

Purified Sika deer antler protein attenuates GM-induced nephrotoxicity by activating Nrf2 pathway and inhibiting NF-κB pathway.

Although gentamicin is widely used as an antibiotic in clinical practice, it also has some side-effects, such as acute kidney injury, which is a common condition caused by the abuse of gentamicin. Sika deer antler protein (SDAPR) can antagonize drug-induced AKI. Since SDAPR is recognized as an effective part of velvet antler, its components were further separated. Two components named SDAP1 and SDAP2 were obtained. The protective effects of SDAPR, SDAP1 and SDAP2 on GM-induced cytotoxicity to HEK293 and its potential mechanisms were studied. MTT and xCELLigence Real-Time cell analysis showed that SDAPR, SDAP1 and SDAP2 could protect HEK293 cells from GM toxicity. Similarly, SDAPR, SDAP1 and SDAP2 can reduce ROS level, reduce oxidative stress and improve inflammation Further studies have shown that SDAPR, SDAP1 and SDAP2 upregulate the Nrf2/HO-1 pathway by increasing the expression of Nrf2 and HO-1, and down-regulate the NF-κB pathway by reducing the protein expression of NF-κB. Annexin V/PI flow cytometry and Hoechst 33258 staining showed that SDAPR, SDAP1 and SDAP2 inhibited GM-induced apoptosis in HEK293 cells. Western blot analysis showed SDAPR, SDAP1 and SDAP2 decreased expression level of Bax and Cleaved-caspase-3, and increased the expression level of Bcl-2. In addition, we examined the feasibility of SDAP1 and SDAP1 to avoid kidney injury in a GM mouse model. In conclusion, SDAPR, SDAP1 and SDAP2 can be used to prevent GM-induced HEK293 cytotoxicity, probably because they have strong anti-oxidative stress, anti-inflammatory and anti-apoptotic effects. And SDAP1 and SDAP2 can inhibit GM-induced acute kidney injury in mice.

Sika deer antler protein against acetaminophen-induced nephrotoxicity by activating Nrf2 and inhibition FoxO1 via PI3K/Akt signaling.

Acetaminophen (APAP)-induced acute kidney injury (AKI) has turned into a typical reason for clinic obtained renal disappointment. In any case, the advancement of prophylaxis procedures and endorsed treatments for APAP-AKI is restricted. Sika deer antler protein (SDAPR) has a protective effect on drug-induced AKI. The reason for this investigation was to clarify the material premise and atomic instrument of the defensive impact of SDAPR on APAP-induced AKI. We conducted column chromatography on SDAPR extracted with Sephadex G-100 and obtained proteins of 2 different components named sika deer antler protein 1 (SDAP1) and sika deer antler protein 2 (SDAP2), respectively. MTT assay and xCELLigence Real-Time Cell Analysis showed that SDAPR, SDAP1 and SDAP2 had protective effects on APAP-induced cytotoxicity in Human kidney tubular epithelial (HK-2) cells. Therefore, we conducted proteomic analysis on SDAPR, SDAP1 and SDAP2. What's more, we inspected them viability of avoiding renal damage in APAP mice and HK-2 cells model. Contrasted and saline, SDAPR, SDAP1 and SDAP2 pretreatment portion conditionally fundamentally constricted heights in kidney damage Markers and the histological changes of renal cylindrical wounds, diminished the quantity of apoptosis-positive rounded cells, initiated NF-E2 p45-related factor 2 (Nrf2), inhibition Forkhead box O 1 transcription factors (FoxO1) and brought down the degrees of renal oxidative stress and apoptosis prompted by APAP. The above security of SDAPR, SDAP1 and SDAP2 was nullified by the Phosphoinositide 3-kinase (PI3K) inhibitor (LY294002) in HK-2 cells. In this manner, our outcomes exhibit that, SDAPR, SDAP1 and SDAP2 against APAP-induced oxidative stress and apoptosis by initiating Nrf2 and restraint FoxO1 through PI3K/Akt signaling.