Development of UroSAM: a machine learning model to automatically identify kidney stone composition from endoscopic video.

Introduction Chemical composition analysis is important in prevention counseling for kidney stone disease. Advances in laser technology have made dusting techniques more prevalent, but this offers no consistent way to collect enough material to send for chemical analysis, leading many to forgo this test. We developed a novel machine learning (ML) model to effectively assess stone composition based on intraoperative endoscopic video data. Methods Two endourologists performed ureteroscopy for kidney stones ≥ 10mm. Representative videos were recorded intraoperatively. Individual frames were extracted from the videos and the stone was outlined by human tracing. An ML model, UroSAM, was built and trained to automatically identify kidney stones in the images and predict the majority stone composition: calcium oxalate monohydrate (COM), dihydrate (COD), calcium phosphate (CAP), or uric acid (UA). UroSAM was built on top of the publicly available Segment Anything Model (SAM) and incorporated a U-Net convolutional neural network (CNN). Discussion A total of 78 ureteroscopy videos were collected; 50 were used for the model after exclusions (32 COM, 8 COD, 8 CAP, 2 UA). The ML model segmented the images with 94.77% precision. Dice coefficient (0.9135) and Intersection over Union (0.8496) confirmed good segmentation performance of the ML model. A video-wise evaluation demonstrated 60% correct classification of stone composition. Subgroup analysis showed correct classification in 84.4% of COM videos. A post-hoc adaptive threshold technique was used to mitigate biasing of the model towards COM due to data imbalance - this improved the overall correct classification to 62% while improving the classification of COD, CAP, and UA videos. Conclusions This study demonstrates the successful development of UroSAM, an ML model that precisely identifies kidney stones from natural endoscopic video data. More high quality video data will improve the performance of the model in classifying the majority stone composition.

Structure-Guided Image Completion with Image-level and Object-level Semantic Discriminators.

Structure-guided image completion aims to inpaint a local region of an image according to an input guidance map from users. While such a task enables many practical applications for interactive editing, existing methods often struggle to hallucinate realistic object instances in complex natural scenes. Such a limitation is partially due to the lack of semantic-level constraints inside the hole region as well as the lack of a mechanism to enforce realistic object generation. In this work, we propose a learning paradigm that consists of semantic discriminators and object-level discriminators for improving the generation of complex semantics and objects. Specifically, the semantic discriminators leverage pretrained visual features to improve the realism of the generated visual concepts. Moreover, the object-level discriminators take aligned instances as inputs to enforce the realism of individual objects. Our proposed scheme significantly improves the generation quality and achieves state-of-the-art results on various tasks, including segmentation-guided completion, edge-guided manipulation and panoptically-guided manipulation on Places2 datasets. Furthermore, our trained model is flexible and can support multiple editing use cases, such as object insertion, replacement, removal and standard inpainting. In particular, our trained model combined with a novel automatic image completion pipeline achieves state-of-the-art results on the standard inpainting task.

Lexicon-Based Sentiment Analysis in Behavioral Research.

A complete science of human behavior requires a comprehensive account of the verbal behavior those humans exhibit. Existing behavioral theories of such verbal behavior have produced compelling insight into language's underlying function, but the expansive program of research those theories deserve has unfortunately been slow to develop. We argue that the status quo's manually implemented and study-specific coding systems are too resource intensive to be worthwhile for most behavior analysts. These high input costs in turn discourage research on verbal behavior overall. We propose lexicon-based sentiment analysis as a more modern and efficient approach to the study of human verbal products, especially naturally occurring ones (e.g., psychotherapy transcripts, social media posts). In the present discussion, we introduce the reader to principles of sentiment analysis, highlighting its usefulness as a behavior analytic tool for the study of verbal behavior. We conclude with an outline of approaches for handling some of the more complex forms of speech, like negation, sarcasm, and speculation. The appendix also provides a worked example of how sentiment analysis could be applied to existing questions in behavior analysis, complete with code that readers can incorporate into their own work.

A Closer Look at the Reflection Formulation in Single Image Reflection Removal.

How to model the effect of reflection is crucial for single image reflection removal (SIRR) task. Modern SIRR methods usually simplify the reflection formulation with the assumption of linear combination of a transmission layer and a reflection layer. However, the large variations in image content and the real-world picture-taking conditions often result in far more complex reflection. In this paper, we introduce a new screen-blur combination based on two important factors, namely the intensity and the blurriness of reflection, to better characterize the reflection formulation in SIRR. Specifically, we present Screen-blur Reflection Networks (SRNet), which executes the screen-blur formulation in its network design and adapts to the complex reflection on real scenes. Technically, SRNet consists of three components: a blended image generator, a reflection estimator and a reflection removal module. The image generator exploits the screen-blur combination to synthesize the training blended images. The reflection estimator learns the reflection layer and a blur degree that measures the level of blurriness for reflection. The reflection removal module further uses the blended image, blur degree and reflection layer to filter out the transmission layer in a cascaded manner. Superior results on three different SIRR methods are reported when generating the training data on the principle of the screen-blur combination. Moreover, extensive experiments on six datasets quantitatively and qualitatively demonstrate the efficacy of SRNet over the state-of-the-art methods.

Prototype-Augmented Self-Supervised Generative Network for Generalized Zero-Shot Learning.

Generalized Zero-Shot Learning (GZSL) aims at recognizing images from both seen and unseen classes by constructing correspondences between visual images and semantic embedding. However, existing methods suffer from a strong bias problem, where unseen images in the target domain tend to be recognized as seen classes in the source domain. To address this issue, we propose a Prototype-augmented Self-supervised Generative Network by integrating self-supervised learning and prototype learning into a feature generating model for GZSL. The proposed model enjoys several advantages. First, we propose a Self-supervised Learning Module to exploit inter-domain relationships, where we introduce anchors as a bridge between seen and unseen categories. In the shared space, we pull the distribution of the target domain away from the source domain and obtain domain-aware features. To our best knowledge, this is the first work to introduce self-supervised learning into GZSL as learning guidance. Second, a Prototype Enhancing Module is proposed to utilize class prototypes to model reliable target domain distribution in finer granularity. In this module, a Prototype Alignment mechanism and a Prototype Dispersion mechanism are combined to guide the generation of better target class features with intra-class compactness and inter-class separability. Extensive experimental results on five standard benchmarks demonstrate that our model performs favorably against state-of-the-art GZSL methods.

Improving Pretrained Language Model Fine-Tuning With Noise Stability Regularization.

The advent of large-scale pretrained language models (PLMs) has contributed greatly to the progress in natural language processing (NLP). Despite its recent success and wide adoption, fine-tuning a PLM often suffers from overfitting, which leads to poor generalizability due to the extremely high complexity of the model and the limited training samples from downstream tasks. To address this problem, we propose a novel and effective fine-tuning framework, named layerwise noise stability regularization (LNSR). Specifically, our method perturbs the input of neural networks with the standard Gaussian or in-manifold noise in the representation space and regularizes each layer's output of the language model. We provide theoretical and experimental analyses to prove the effectiveness of our method. The empirical results show that our proposed method outperforms several state-of-the-art algorithms, such as [Formula: see text] norm and start point (L2-SP), Mixout, FreeLB, and smoothness inducing adversarial regularization and Bregman proximal point optimization (SMART). In addition to evaluating the proposed method on relatively simple text classification tasks, similar to the prior works, we further evaluate the effectiveness of our method on more challenging question-answering (QA) tasks. These tasks present a higher level of difficulty, and they provide a larger amount of training examples for tuning a well-generalized model. Furthermore, the empirical results indicate that our proposed method can improve the ability of language models to domain generalization.

Unsupervised anomaly detection by densely contrastive learning for time series data.

Time series data continuously collected by different sensors play an essential role in monitoring and predicting events in many real-world applications, and anomaly detection for time series has received increasing attention during the past decades. In this paper, we propose an anomaly detection method by densely contrasting the whole time series with its sub-sequences at different timestamps in a latent space. Our approach leverages the locality property of convolutional neural networks (CNN) and integrates position embedding to effectively capture local features for sub-sequences. Simultaneously, we employ an attention mechanism to extract global features from the entire time series. By combining these local and global features, our model is trained using both instance-level contrastive learning loss and distribution-level alignment loss. Furthermore, we introduce a reconstruction loss applied to the extracted global features to prevent the potential loss of information. To validate the efficacy of our proposed technique, we conduct experiments on publicly available time-series datasets for anomaly detection. Additionally, we evaluate our method on an in-house mobile phone dataset aimed at monitoring the status of Parkinson's disease, all within an unsupervised learning framework. Our results demonstrate the effectiveness and potential of the proposed approach in tackling anomaly detection in time series data, offering promising applications in real-world scenarios.

LibFewShot: A Comprehensive Library for Few-Shot Learning.

Few-shot learning, especially few-shot image classification, has received increasing attention and witnessed significant advances in recent years. Some recent studies implicitly show that many generic techniques or "tricks", such as data augmentation, pre-training, knowledge distillation, and self-supervision, may greatly boost the performance of a few-shot learning method. Moreover, different works may employ different software platforms, backbone architectures and input image sizes, making fair comparisons difficult and practitioners struggle with reproducibility. To address these situations, we propose a comprehensive library for few-shot learning (LibFewShot) by re-implementing eighteen state-of-the-art few-shot learning methods in a unified framework with the same single codebase in PyTorch. Furthermore, based on LibFewShot, we provide comprehensive evaluations on multiple benchmarks with various backbone architectures to evaluate common pitfalls and effects of different training tricks. In addition, with respect to the recent doubts on the necessity of meta- or episodic-training mechanism, our evaluation results confirm that such a mechanism is still necessary especially when combined with pre-training. We hope our work can not only lower the barriers for beginners to enter the area of few-shot learning but also elucidate the effects of nontrivial tricks to facilitate intrinsic research on few-shot learning.

Infant death prediction using machine learning: A population-based retrospective study.

BACKGROUND: Despite declines in infant death rates in recent decades in the United States, the national goal of reducing infant death has not been reached. This study aims to predict infant death using machine-learning approaches. METHODS: A population-based retrospective study of live births in the United States between 2016 and 2021 was conducted. Thirty-three factors related to birth facility, prenatal care and pregnancy history, labor and delivery, and newborn characteristics were used to predict infant death. RESULTS: XGBoost demonstrated superior performance compared to the other four compared machine learning models. The original imbalanced dataset yielded better results than the balanced datasets created through oversampling procedures. The cross-validation of the XGBoost-based model consistently achieved high performance during both the pre-pandemic (2016-2019) and pandemic (2020-2021) periods. Specifically, the XGBoost-based model performed exceptionally well in predicting neonatal death (AUC: 0.98). The key predictors of infant death were identified as gestational age, birth weight, 5-min APGAR score, and prenatal visits. A simplified model based on these four predictors resulted in slightly inferior yet comparable performance to the all-predictor model (AUC: 0.91 vs. 0.93). Furthermore, the four-factor risk classification system effectively identified infant deaths in 2020 and 2021 for high-risk (88.7%-89.0%), medium-risk (4.6%-5.4%), and low-risk groups (0.1), outperforming the risk screening tool based on accumulated risk factors. CONCLUSIONS: XGBoost-based models excel in predicting infant death, providing valuable prognostic information for perinatal care education and counselling. The simplified four-predictor classification system could serve as a practical alternative for infant death risk prediction.

Context-Aware Proposal-Boundary Network With Structural Consistency for Audiovisual Event Localization.

Audiovisual event localization aims to localize the event that is both visible and audible in a video. Previous works focus on segment-level audio and visual feature sequence encoding and neglect the event proposals and boundaries, which are crucial for this task. The event proposal features provide event internal consistency between several consecutive segments constructing one proposal, while the event boundary features offer event boundary consistency to make segments located at boundaries be aware of the event occurrence. In this article, we explore the proposal-level feature encoding and propose a novel context-aware proposal-boundary (CAPB) network to address audiovisual event localization. In particular, we design a local-global context encoder (LGCE) to aggregate local-global temporal context information for visual sequence, audio sequence, event proposals, and event boundaries, respectively. The local context from temporally adjacent segments or proposals contributes to event discrimination, while the global context from the entire video provides semantic guidance of temporal relationship. Furthermore, we enhance the structural consistency between segments by exploiting the above-encoded proposal and boundary representations. CAPB leverages the context information and structural consistency to obtain context-aware event-consistent cross-modal representation for accurate event localization. Extensive experiments conducted on the audiovisual event (AVE) dataset show that our approach outperforms the state-of-the-art methods by clear margins in both supervised event localization and cross-modality localization.

Domain-Scalable Unpaired Image Translation via Latent Space Anchoring.

Unpaired image-to-image translation (UNIT) aims to map images between two visual domains without paired training data. However, given a UNIT model trained on certain domains, it is difficult for current methods to incorporate new domains because they often need to train the full model on both existing and new domains. To address this problem, we propose a new domain-scalable UNIT method, termed as latent space anchoring, which can be efficiently extended to new visual domains and does not need to fine-tune encoders and decoders of existing domains. Our method anchors images of different domains to the same latent space of frozen GANs by learning lightweight encoder and regressor models to reconstruct single-domain images. In the inference phase, the learned encoders and decoders of different domains can be arbitrarily combined to translate images between any two domains without fine-tuning. Experiments on various datasets show that the proposed method achieves superior performance on both standard and domain-scalable UNIT tasks in comparison with the state-of-the-art methods.

Few-Shot Partial Multi-View Learning.

It is often the case that data are with multiple views in real-world applications. Fully exploring the information of each view is significant for making data more representative. However, due to various limitations and failures in data collection and pre-processing, it is inevitable for real data to suffer from view missing and data scarcity. The coexistence of these two issues makes it more challenging to achieve the pattern classification task. Currently, to our best knowledge, few appropriate methods can well-handle these two issues simultaneously. Aiming to draw more attention from the community to this challenge, we propose a new task in this paper, called few-shot partial multi-view learning, which focuses on overcoming the negative impact of the view-missing issue in the low-data regime. The challenges of this task are twofold: (i) it is difficult to overcome the impact of data scarcity under the interference of missing views; (ii) the limited number of data exacerbates information scarcity, thus making it harder to address the view-missing issue in turn. To address these challenges, we propose a new unified Gaussian dense-anchoring method. The unified dense anchors are learned for the limited partial multi-view data, thereby anchoring them into a unified dense representation space where the influence of data scarcity and view missing can be alleviated. We conduct extensive experiments to evaluate our method. The results on Cub-googlenet-doc2vec, Handwritten, Caltech102, Scene15, Animal, ORL, tieredImagenet, and Birds-200-2011 datasets validate its effectiveness. The codes will be released at https://github.com/zhouyuan888888/UGDA.

CoSeg: Cognitively Inspired Unsupervised Generic Event Segmentation.

Some cognitive research has discovered that humans accomplish event segmentation as a side effect of event anticipation. Inspired by this discovery, we propose a simple yet effective end-to-end self-supervised learning framework for event segmentation/boundary detection. Unlike the mainstream clustering-based methods, our framework exploits a transformer-based feature reconstruction scheme to detect event boundaries by reconstruction errors. This is consistent with the fact that humans spot new events by leveraging the deviation between their prediction and what is perceived. Thanks to their heterogeneity in semantics, the frames at boundaries are difficult to be reconstructed (generally with large reconstruction errors), which is favorable for event boundary detection. In addition, since the reconstruction occurs on the semantic feature level instead of the pixel level, we develop a temporal contrastive feature embedding (TCFE) module to learn the semantic visual representation for frame feature reconstruction (FFR). This procedure is like humans building up experiences with "long-term memory." The goal of our work is to segment generic events rather than localize some specific ones. We focus on achieving accurate event boundaries. As a result, we adopt the F1 score (Precision/Recall) as our primary evaluation metric for a fair comparison with previous approaches. Meanwhile, we also calculate the conventional frame-based mean over frames (MoF) and intersection over union (IoU) metric. We thoroughly benchmark our work on four publicly available datasets and demonstrate much better results. The source code is available at https://github.com/wang3702/CoSeg.

Predicting Adverse Neonatal Outcomes for Preterm Neonates with Multi-Task Learning.

Diagnosis of adverse neonatal outcomes is crucial for preterm survival since it enables doctors to provide timely treatment. Machine learning (ML) algorithms have been demonstrated to be effective in predicting adverse neonatal outcomes. However, most previous ML-based methods have only focused on predicting a single outcome, ignoring the potential correlations between different outcomes, and potentially leading to suboptimal results and overfitting issues. In this work, we first analyze the correlations between three adverse neonatal outcomes and then formulate the diagnosis of multiple neonatal outcomes as a multi-task learning (MTL) problem. We then propose an MTL framework to jointly predict multiple adverse neonatal outcomes. In particular, the MTL framework contains shared hidden layers and multiple task-specific branches. Extensive experiments have been conducted using Electronic Health Records (EHRs) from 121 preterm neonates. Empirical results demonstrate the effectiveness of the MTL framework. Furthermore, the feature importance is analyzed for each neonatal outcome, providing insights into model interpretability.

Human behavior in the time of COVID-19: Learning from big data.

Since the World Health Organization (WHO) characterized COVID-19 as a pandemic in March 2020, there have been over 600 million confirmed cases of COVID-19 and more than six million deaths as of October 2022. The relationship between the COVID-19 pandemic and human behavior is complicated. On one hand, human behavior is found to shape the spread of the disease. On the other hand, the pandemic has impacted and even changed human behavior in almost every aspect. To provide a holistic understanding of the complex interplay between human behavior and the COVID-19 pandemic, researchers have been employing big data techniques such as natural language processing, computer vision, audio signal processing, frequent pattern mining, and machine learning. In this study, we present an overview of the existing studies on using big data techniques to study human behavior in the time of the COVID-19 pandemic. In particular, we categorize these studies into three groups-using big data to measure, model, and leverage human behavior, respectively. The related tasks, data, and methods are summarized accordingly. To provide more insights into how to fight the COVID-19 pandemic and future global catastrophes, we further discuss challenges and potential opportunities.

Cascade Multi-Level Transformer Network for Surgical Workflow Analysis.

Surgical workflow analysis aims to recognise surgical phases from untrimmed surgical videos. It is an integral component for enabling context-aware computer-aided surgical operating systems. Many deep learning-based methods have been developed for this task. However, most existing works aggregate homogeneous temporal context for all frames at a single level and neglect the fact that each frame has its specific need for information at multiple levels for accurate phase prediction. To fill this gap, in this paper we propose Cascade Multi-Level Transformer Network (CMTNet) composed of cascaded Adaptive Multi-Level Context Aggregation (AMCA) modules. Each AMCA module first extracts temporal context at the frame level and the phase level and then fuses frame-specific spatial feature, frame-level temporal context, and phase-level temporal context for each frame adaptively. By cascading multiple AMCA modules, CMTNet is able to gradually enrich the representation of each frame with the multi-level semantics that it specifically requires, achieving better phase prediction in a frame-adaptive manner. In addition, we propose a novel refinement loss for CMTNet, which explicitly guides each AMCA module to focus on extracting the key context for refining the prediction of the previous stage in terms of both prediction confidence and smoothness. This further enhances the quality of the extracted context effectively. Extensive experiments on the Cholec80 and the M2CAI datasets demonstrate that CMTNet achieves state-of-the-art performance.

Semantic and Relation Modulation for Audio-Visual Event Localization.

We study the problem of localizing audio-visual events that are both audible and visible in a video. Existing works focus on encoding and aligning audio and visual features at the segment level while neglecting informative correlation between segments of the two modalities and between multi-scale event proposals. We propose a novel Semantic and Relation Modulation Network (SRMN) to learn the above correlation and leverage it to modulate the related auditory, visual, and fused features. In particular, for semantic modulation, we propose intra-modal normalization and cross-modal normalization. The former modulates features of a single modality with the event-relevant semantic guidance of the same modality. The latter modulates features of two modalities by establishing and exploiting the cross-modal relationship. For relation modulation, we propose a multi-scale proposal modulating module and a multi-alignment segment modulating module to introduce multi-scale event proposals and enable dense matching between cross-modal segments, which strengthen correlations between successive segments within one proposal and between all segments. With the features modulated by the correlation information regarding audio-visual events, SRMN performs accurate event localization. Extensive experiments conducted on the public AVE dataset demonstrate that our method outperforms the state-of-the-art methods in both supervised event localization and cross-modality localization tasks.

Adaptive Siamese Tracking With a Compact Latent Network.

In this article, we provide an intuitive viewing to simplify the Siamese-based trackers by converting the tracking task to a classification. Under this viewing, we perform an in-depth analysis for them through visual simulations and real tracking examples, and find that the failure cases in some challenging situations can be regarded as the issue of missing decisive samples in offline training. Since the samples in the initial (first) frame contain rich sequence-specific information, we can regard them as the decisive samples to represent the whole sequence. To quickly adapt the base model to new scenes, a compact latent network is presented via fully using these decisive samples. Specifically, we present a statistics-based compact latent feature for fast adjustment by efficiently extracting the sequence-specific information. Furthermore, a new diverse sample mining strategy is designed for training to further improve the discrimination ability of the proposed compact latent network. Finally, a conditional updating strategy is proposed to efficiently update the basic models to handle scene variation during the tracking phase. To evaluate the generalization ability and effectiveness and of our method, we apply it to adjust three classical Siamese-based trackers, namely SiamRPN++, SiamFC, and SiamBAN. Extensive experimental results on six recent datasets demonstrate that all three adjusted trackers obtain the superior performance in terms of the accuracy, while having high running speed.

A Multilayer Framework for Online Metric Learning.

Online metric learning (OML) has been widely applied in classification and retrieval. It can automatically learn a suitable metric from data by restricting similar instances to be separated from dissimilar instances with a given margin. However, the existing OML algorithms have limited performance in real-world classifications, especially, when data distributions are complex. To this end, this article proposes a multilayer framework for OML to capture the nonlinear similarities among instances. Different from the traditional OML, which can only learn one metric space, the proposed multilayer OML (MLOML) takes an OML algorithm as a metric layer and learns multiple hierarchical metric spaces, where each metric layer follows a nonlinear layer for the complicated data distribution. Moreover, the forward propagation (FP) strategy and backward propagation (BP) strategy are employed to train the hierarchical metric layers. To build a metric layer of the proposed MLOML, a new Mahalanobis-based OML (MOML) algorithm is presented based on the passive-aggressive strategy and one-pass triplet construction strategy. Furthermore, in a progressively and nonlinearly learning way, MLOML has a stronger learning ability than traditional OML in the case of limited available training data. To make the learning process more explainable and theoretically guaranteed, theoretical analysis is provided. The proposed MLOML enjoys several nice properties, indeed learns a metric progressively, and performs better on the benchmark datasets. Extensive experiments with different settings have been conducted to verify these properties of the proposed MLOML.

Defensive Few-Shot Learning.

This article investigates a new challenging problem called defensive few-shot learning in order to learn a robust few-shot model against adversarial attacks. Simply applying the existing adversarial defense methods to few-shot learning cannot effectively solve this problem. This is because the commonly assumed sample-level distribution consistency between the training and test sets can no longer be met in the few-shot setting. To address this situation, we develop a general defensive few-shot learning (DFSL) framework to answer the following two key questions: (1) how to transfer adversarial defense knowledge from one sample distribution to another? (2) how to narrow the distribution gap between clean and adversarial examples under the few-shot setting? To answer the first question, we propose an episode-based adversarial training mechanism by assuming a task-level distribution consistency to better transfer the adversarial defense knowledge. As for the second question, within each few-shot task, we design two kinds of distribution consistency criteria to narrow the distribution gap between clean and adversarial examples from the feature-wise and prediction-wise perspectives, respectively. Extensive experiments demonstrate that the proposed framework can effectively make the existing few-shot models robust against adversarial attacks. Code is available at https://github.com/WenbinLee/DefensiveFSL.git.