Vertical Sleeve Gastrectomy Offers Protection against Disturbed Flow-Induced Atherosclerosis in High-Fat Diet-Fed Mice.

Bariatric surgery reduces body weight, enhances metabolic and diabetic control, and improves outcomes on obesity-related comorbidities. However, the mechanisms mediating this protection against cardiovascular diseases remain unclear. We investigated the effect of sleeve gastrectomy (SG) on vascular protection in response to shear stress-induced atherosclerosis using an overweighted and carotid artery ligation mouse model. Eight-week-old male wild-type mice (C57BL/6J) were fed a high-fat diet (HFD) for two weeks to induce weight gain and dysmetabolism. SG was performed in HFD-fed mice. Two weeks after the SG procedure, partial carotid-artery ligation was performed to promote disturbed flow-induced atherosclerosis. Compared with the control mice, HFD-fed wild-type mice exhibited increased body weight, total cholesterol level, hemoglobin A1c, and enhanced insulin resistance; SG significantly reversed these adverse effects. As expected, HFD-fed mice exhibited greater neointimal hyperplasia and atherosclerotic plaques than the control group, and the SG procedure attenuated HFD-promoted ligation-induced neointimal hyperplasia and arterial elastin fragmentation. Besides, HFD promoted ligation-induced macrophage infiltration, matrix metalloproteinase-9 expression, upregulation of inflammatory cytokines, and increased vascular endothelial growth factor secretion. SG significantly reduced the above-mentioned effects. Moreover, HFD restriction partially reversed the intimal hyperplasia caused by carotid artery ligation; however, this protective effect was significantly lower than that observed in SG-operated mice. Our study demonstrated that HFD deteriorates shear stress-induced atherosclerosis and SG mitigates vascular remodeling, and this protective effect was not comparable in HFD restriction group. These findings provide a rationale for using bariatric surgery to counter atherosclerosis in morbid obesity.

All-Directional DOA Estimation for Ultra-Wideband Regular Tetrahedral Array Using Wrapped PDoA.

In this paper, we proposed a Regular Tetrahedral Array (RTA) to cope with various types of sensors expected in Ultra-Wideband (UWB) localization requiring all-directional detection capability and high accuracy, such as indoor Internet-of-Things (IoT) devices at diverse locations, UAVs performing aerial navigation, collision avoidance and takeoff/landing guidance. The RTA is deployed with four synchronized Ultra-Wideband (UWB) transceivers on its vertexes and configured with arbitrary aperture. An all-directional DOA estimation algorithm using combined TDoA and wrapped PDoA was conducted. The 3D array RTA was decomposed into four planar subarrays solved as phased Uniform Circular Array (UCA) respectively. A new cost function based on geometric identical and variable neighborhood search strategy using TDoA information was proposed for ambiguity resolution. The results of simulation and numerical experiments demonstrated excellent performance of the proposed RTA and corresponding algorithm.

A trend extraction method based on logistic functions and envelopes.

A method of step characteristic trend extraction based on logistic functions and envelopes (LFEs) is proposed in this paper. Compared with the existing trend extraction methods, the LFE method can determine the starting position of the step trend using a logistic function and extract the local trend using upper and lower envelopes. This method enhances the extraction accuracy and reduces the computation time. To verify the effectiveness of the LFE method, a simulated signal with a step trend feature was compared with the five-spot triple smoothing method, wavelet transform method and empirical mode decomposition-based method. All of these methods were applied to a real shock signal. The results demonstrate that the LFE method can reliably and accurately extract the trends with step characteristics based on less prior knowledge. Moreover, the proposed technique is suitable for industrial online applications.

Highly efficient removal of thallium(I) by facilely fabricated amorphous titanium dioxide from water and wastewater.

In this study, amorphous hydrous titanium dioxide was synthesized by a facile precipitation method at room temperature, aiming to effectively remove thallium(I) from water. The titanium dioxide prepared using ammonia as precipitant (TiO2I) is more effective for thallium(I) uptake than the one synthesized with sodium hydroxide (TiO2II). The TiO2 obtained particles are amorphous, aggregates of many nanoparticles and irregular in shape. The thallium(I) uptake increases with the rise of solution pH value. Under neutral pH conditions, the maximal thallium(I) adsorption capacities of TiO2I and TiO2II are 302.6 and 230.3 mg/g, respectively, outperforming most of the reported adsorbents. The amorphous TiO2 has high selectivity towards thallium(I) in the presence of multiple cations such as K+, Ca2+, Mg2+, Zn2+ and Ni2+. Moreover, the TiO2I is efficient in removing thallium(I) from real river water and mining wastewater. Additionally, the spent TiO2I can be regenerated using hydrochloric acid solution and reused. The Tl(I) adsorption is achieved via replacing the H+ in hydroxyl group on the surface of TiO2 and forming inner-sphere surface complexes. Owing to its high efficiency, facile synthesis and environmental friendliness, the TiO2I has the potential to be used as an alternative adsorbent to remove Tl(I) from water.

Polyvinyl alcohol-stabilized granular Fe-Mn binary oxide as an effective adsorbent for simultaneous removal of arsenate and arsenite.

A novel granular Fe-Mn (GFM) binary oxide sorbent, with a diameter of approximate 2.0 mm and a length of 2.0-3.0 mm, was successfully prepared using extrusion granulation method in this study. The GFM sorbent is highly porous with a BET-specific surface area of 210.3 m2/g. It shows high effectiveness in simultaneously adsorbing As(V) and As(III). The maximal sorption capacities for As(V) and As(III) are 33.2 and 50.7 mg/g at pH 7.0 ± 0.1, respectively, which are superior to most of granular sorbents reported in the literature. The present Ca2+, Mg2+, humic acids and fulvic acids do not have obvious influence on the arsenic sorption. But, coexisting anions affect negatively arsenic sorption in the following order: H2PO4 - > SiO3 2- > HCO3 - > SO4 2-. NaOH solution is an effective eluent for regeneration of the arsenic-loaded GFM. The GFM packed in the fixed-bed column can treat approximately 3400 and 6500 bed volumes of simulated groundwater containing 233 µg/L As(V) and As(III), respectively, before the arsenic concentration in the effluent reached a drinking water limit of 10 µg/L. The features of high effectiveness, selectivity and reusability make the GFM a potential alternative to remove simultaneously As(V) and As(III) from groundwater.