ABSTRACT
To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.
Subject(s)
CD4-Positive T-Lymphocytes/pathology , Coronavirus Infections/blood , Coronavirus Infections/immunology , Cytokines/blood , Pneumonia, Viral/blood , Pneumonia, Viral/immunology , Adolescent , Adult , Aged , Betacoronavirus , CD4 Lymphocyte Count , CD4-CD8 Ratio , COVID-19 , Child , Coronavirus Infections/diagnosis , Female , Humans , Interleukin-6/blood , Lymphopenia/blood , Lymphopenia/pathology , Male , Middle Aged , Pandemics , Pneumonia, Viral/diagnosis , SARS-CoV-2 , Severity of Illness Index , Tumor Necrosis Factor-alpha/bloodABSTRACT
OBJECTIVE: To analyze the association between CT features and survival rate of GIST, and to elucidate the significance of CT features for prognosis. METHODS: Clinical data of 38 patients with pathologically and immunohistochemically proven GISTs, including 11 patients at high biological risk, 13 at moderate risk, 10 at low risk and 4 at very low risk. Patients who underwent CT examination for primary tumors were included. Association between CT features and survival rate was examined. RESULTS: The mean follow-up period of 38 cases was 42.6 months and the 3-year survival rate was 86.8%. Univariate analysis revealed that tumor growth pattern, diameter, lobulated shape, irregular margin, necrosis, ulceration, adjacent invasion, and liver metastasis were associated factors of 3-year survival rate. Circumference invasion and hepatic metastases predicted poor 3-year survival rate (P<0.05). Calcification and intensity were not associated with prognosis (P>0.05). CONCLUSIONS: CT can demonstrate the tumor growth pattern, size, shape, boundary, density, necrosis, hemorrhage, calcification, ulcer, enhance features and metastasis. CT can play an important role in estimating the survival rate of GIST.
