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1.
Braz J Med Biol Res ; 46(9): 797-802, 2013 Sep.
Article in English | MEDLINE | ID: mdl-24036911

ABSTRACT

In this study, electrical and structural remodeling of ventricles was examined in tachycardia-induced heart failure (HF). We studied two groups of weight-matched adult male mongrel dogs: a sham-operated control group (n=5) and a pacing group (n=5) that underwent ventricular pacing at 230 bpm for 3 weeks. Clinical symptoms of congestive HF were observed in both groups. Their hemodynamic parameters were determined and the severity of the HF was evaluated by M-mode echocardiography. Changes in heart morphology were observed by scanning electron and light microscopy. Ventricular action potential duration (APD), as well as the 50 and 90% APD were measured in both groups. All dogs exhibited clinical symptoms of congestive HF after rapid right ventricular pacing for 3 weeks. These data indicate that rapid, right ventricular pacing produces a useful experimental model of low-output HF in dogs, characterized by biventricular pump dysfunction, biventricular cardiac dilation, and non-ischemic impairment of left ventricular contractility. Electrical and structural myocardial remodeling play an essential role in congestive HF progression, and should thus be prevented.


Subject(s)
Action Potentials/physiology , Heart Failure/physiopathology , Hemodynamics/physiology , Tachycardia/complications , Ventricular Remodeling/physiology , Animals , Cardiac Pacing, Artificial/methods , Dogs , Echocardiography , Electric Conductivity , Heart Failure/etiology , Male , Myocardium/pathology , Ventricular Function
2.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;46(9): 797-802, 19/set. 2013. tab, graf
Article in English | LILACS | ID: lil-686580

ABSTRACT

In this study, electrical and structural remodeling of ventricles was examined in tachycardia-induced heart failure (HF). We studied two groups of weight-matched adult male mongrel dogs: a sham-operated control group (n=5) and a pacing group (n=5) that underwent ventricular pacing at 230 bpm for 3 weeks. Clinical symptoms of congestive HF were observed in both groups. Their hemodynamic parameters were determined and the severity of the HF was evaluated by M-mode echocardiography. Changes in heart morphology were observed by scanning electron and light microscopy. Ventricular action potential duration (APD), as well as the 50 and 90% APD were measured in both groups. All dogs exhibited clinical symptoms of congestive HF after rapid right ventricular pacing for 3 weeks. These data indicate that rapid, right ventricular pacing produces a useful experimental model of low-output HF in dogs, characterized by biventricular pump dysfunction, biventricular cardiac dilation, and non-ischemic impairment of left ventricular contractility. Electrical and structural myocardial remodeling play an essential role in congestive HF progression, and should thus be prevented.


Subject(s)
Animals , Dogs , Male , Action Potentials/physiology , Heart Failure/physiopathology , Hemodynamics/physiology , Tachycardia/complications , Ventricular Remodeling/physiology , Cardiac Pacing, Artificial/methods , Echocardiography , Electric Conductivity , Heart Failure/etiology , Myocardium/pathology , Ventricular Function
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