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J Asian Nat Prod Res ; 21(6): 507-515, 2019 Jun.
Article in English | MEDLINE | ID: mdl-29597834

ABSTRACT

Four new compounds N-salicyl-3-hydroxyanthranilic acid methyl ester (1), N-(2'-dehydroxysalicyl)-3-hydroxyanthranilic acid methyl ester (2), methyl-4-ß-D-allopyranosyl-ferulate (3), and methyl-4-ß-D-gulopyranosyl-cinnamate (4), along with six known compounds (5-10), were isolated from the roots of Aconitum carmichelii Debx. Their structures were elucidated on the basis of spectral data analysis, including 1D, 2D-NMR, and HR-ESI-MS. Compounds 1 and 2 showed the inhibition of nitric oxide (NO) production with IC50 values of 9.13 and 19.94 µM, respectively.


Subject(s)
Aconitum/chemistry , Cinnamates/chemistry , Plant Roots/chemistry , ortho-Aminobenzoates/chemistry , Animals , Cinnamates/pharmacology , Drugs, Chinese Herbal , Glucosides/chemistry , Glucosides/pharmacology , Magnetic Resonance Spectroscopy , Mice , Molecular Structure , Nitric Oxide/antagonists & inhibitors , Nitric Oxide/biosynthesis , RAW 264.7 Cells , Spectrometry, Mass, Electrospray Ionization , ortho-Aminobenzoates/pharmacology
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