ABSTRACT
No disponible
Subject(s)
Humans , Female , Adult , Carcinoid Tumor/complications , Carcinoid Tumor/surgery , Carcinoid Tumor , Lymph Node Excision/methods , Laparotomy/methods , Bile Duct Neoplasms/complications , Bile Duct Neoplasms/surgery , Bile Duct Neoplasms , BiopsyABSTRACT
AIM: To report our experience with long-term outcomes after multimodal management therapy. METHODS: An observational retrospective study was performed containing seven patients with hepatoblastoma (Hbl) treated in our institution, a tertiary referral center, from 2003 to 2011. Demographic, preoperative, surgical, and outcome variables were collected. A survival analysis and a review of the current literature related to combination neoadjuvant chemotherapy and surgical resection on Hbl were performed. RESULTS: The median age at surgery was 14.4 mo, with a male to female ratio of 4:3. Pretext staging at diagnosis was as follows: stageâ I, 4 cases; stage II, 2 patients; and stage III, 1 case. Mean pretreatment tumor volume was 735 cm(3). Five out of seven patients received neoadjuvant chemotherapy according to SIOPEL-3 or SIOPEL-6 protocols. Tumor volume and alpha-fetoprotein levels significantly dropped after neoadjuvant therapy. Surgical procedures performed included hemihepatectomies, segmentectomies and atypical resection. All patients received chemotherapy after surgery. Median postoperative hospital stay was 8 d. All patients were alive and disease-free after a median follow-up period of 23 mo. With regards to the literature review, seventeen articles were found that were related to our search. CONCLUSION: Our series shows how multimodal management of Hbl, exhaustive control and a meticulous surgical approach leads to almost 100% complete resection with optimal postoperative results.
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Hepatectomy , Hepatoblastoma/therapy , Liver Neoplasms/therapy , Neoadjuvant Therapy , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Chemotherapy, Adjuvant , Child, Preschool , Disease-Free Survival , Female , Hepatectomy/adverse effects , Hepatectomy/mortality , Hepatoblastoma/blood , Hepatoblastoma/mortality , Hepatoblastoma/pathology , Humans , Infant , Length of Stay , Liver Neoplasms/blood , Liver Neoplasms/mortality , Liver Neoplasms/pathology , Male , Neoadjuvant Therapy/adverse effects , Neoadjuvant Therapy/mortality , Neoplasm Staging , Retrospective Studies , Spain , Tertiary Care Centers , Time Factors , Tomography, X-Ray Computed , Treatment Outcome , Tumor Burden , alpha-Fetoproteins/metabolismABSTRACT
No disponible
Subject(s)
Humans , Neoplasm Metastasis , Liver Neoplasms/surgery , Lung Neoplasms/surgery , Diaphragm/surgerySubject(s)
Adenocarcinoma/secondary , Adenocarcinoma/surgery , Hepatectomy/methods , Liver Neoplasms/secondary , Liver Neoplasms/surgery , Lung Neoplasms/secondary , Lung Neoplasms/surgery , Pneumonectomy/methods , Sigmoid Neoplasms/pathology , Diaphragm , Female , Humans , Middle Aged , Reproducibility of ResultsABSTRACT
Duodenal diverticula are a relatively common condition. They are asymptomatic, unless they become complicated, with perforation being the rarest but most severe complication. Surgical treatment is the most frequently performed approach. We report the case of a patient with a perforated duodenal diverticulum, which was diagnosed early and treated conservatively with antibiotics and percutaneous drainage of secondary retroperitoneal abscesses. We suggest this method could be an acceptable option for the management of similar cases, provided that the patient is in good general condition and without septic signs.
