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5.
Lancet ; 1(8536): 763-5, 1987 Apr 04.
Article in English | MEDLINE | ID: mdl-2882180

ABSTRACT

A randomised therapeutic trial of 13-cis-retinoic acid was carried out in 70 patients with myelodysplastic syndrome having 5% or fewer marrow blast cells. Among non-sideroblastic patients the 1-year survival in the treated group was 77%, compared with 36% in the control group. There were too few deaths among patients with sideroblastic anaemia to allow any effect of therapy on survival to be evaluated.


Subject(s)
Myelodysplastic Syndromes/drug therapy , Tretinoin/therapeutic use , Adult , Aged , Aged, 80 and over , Anemia, Sideroblastic/drug therapy , Anemia, Sideroblastic/mortality , Clinical Trials as Topic , Female , Humans , Isomerism , Isotretinoin , Male , Middle Aged , Myelodysplastic Syndromes/mortality , Random Allocation
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