[Improvement of laboratory diagnostics of metabolic syndrome with arterial hypertension in elderly patients.]

Metabolic syndrome (MS) is considered an age-associated pathology, often combined with hypertension (AH) and has a high prevalence in the elderly. However, a comparative study of the broad spectrum of proinflammatory and anti-inflammatory interleukins with an assessment of their informative value in elderly patients WITH MS with AH was not carried out. The aim of the study was to improve the diagnosis of MS with hypertension in elderly patients based on the analysis of the informativity of serum interleukins.. The content of interleukins in serum was studied in 86 patients with MS and AH aged 60-75 years and 35 persons without MS and AH, comparable in age and sex. It was found that for the diagnosis of S in combination with AH as the leading laboratory markers of systemic immunity it is necessary to use highly informative IL-8, IL-1B, IL-4 and IL-10. Other serum interleukins (Il-6, IL-2, TNF-α, interferon-É£, interferon-α and IL-18) can be considered as additional markers in the diagnosis of MS with hypertension in the elderly.

[The effect of antihypertensive chronotherapy on indicators of the daily blood pressure profile in elderly patients with arterial hypertension with a history of myocardial infarction.]

Traditional treatment regimens for patients with hypertension are not always effective and need to be improved based on the principles of chronobiology. The purpose of this work is to analyze the effect of preventive chronotherapy with amlodipine, lisinopril, and rosuvastatin on daily blood pressure monitoring. In 62 patients with a history of myocardial infarction and hypertension at the age of 60-74, a fixed combination of amlodipine, lisinopril and rosuvastatin at a dose of 5/10/10 mg 2 hours before reaching maximum systolic blood pressure (preventive chronotherapy), in 63 patients with similar diseases and age, this drug is taken at a dose of 5/10/10mg in the evening, and in 58 people - in the morning (traditional treatment). Daily monitoring of blood pressure before and 6 months after treatment was performed by the «SpacelabsMedical¼ device (USA) with the calculation of generally accepted indicators. The greatest effectiveness of preventive chronotherapy in comparison with other treatment options for achieving the target blood pressure level, reducing the time indices and the variability of systolic blood pressure has been established, which allows us to recommend this fixed combination in geriatric practice.