ABSTRACT
Synthesis and physico-chemical properties of some 3-benzyl- and 3-phenacyl-4-thioxo-5-benzylidenethiazolidin-2-one derivatives are described. Fifteen new compounds were synthesized from thiazolidin-2-one by thionation of the 4-carbonyle, alkylation of the 3-N and aldolisation-crotonisation of 5-CH(2) with aromatic aldehydes. Soon, these new compounds will be tested for their bacteriostatic activity.
Subject(s)
Anti-Infective Agents/chemical synthesis , Thiazoles/chemical synthesis , Thiazoles/pharmacology , Alkylation , Anti-Infective Agents/pharmacology , Indicators and ReagentsABSTRACT
The synthesis and physicochemical properties of 4-butyl-2H-benzo[1,4]thiazin-3-one derivatives are described. These new compounds were synthesised by alkylation in 4-N position and acylation and/or alkylation of 6-NH2 by phase transfer catalysis. Acid hydrolysis of 6-alkylacylamino group yielded 6-alkylamino-4-butyl-2H-benzo[1,4]thiazin-3-ones. The antimicrobial in vitro activity was determined on five compounds.
Subject(s)
Anti-Infective Agents/chemical synthesis , Thiazines/chemical synthesis , Anti-Infective Agents/chemistry , Anti-Infective Agents/pharmacology , Microbial Sensitivity Tests , Thiazines/pharmacologyABSTRACT
Synthesis and physico-chemical properties of six 5-arylidène-3-benzyl-1-methyl-2-thioxoimidazolidin-4-ones and three 2-arylidene-6-nitro-2H-1,4-benzothiazin-3(4H)-ones have been described. These new compounds were synthetised by Knoevenagel condensation reaction from aromatic aldehydes. The N-alkylation reaction of arylidenebenzothiazines by methyl iodide give the N-methylarylidenebenzothiazines.
Subject(s)
Imidazoles/chemical synthesis , Thiazines/chemical synthesis , Chemical Phenomena , Chemistry, Physical , Magnetic Resonance Spectroscopy , StereoisomerismABSTRACT
Synthesis and physico-chemical properties of new 3-benzyl-4-thioxo-5-arylideneimidazolidine-2-ones and 3-benzyl-5-arylideneimidazolidine-2,4-dione are described. These compounds were synthesized by condensation reaction from aromatic aldehydes and 3-substituted imidazolidine-2,4-diones or 4-thioxoimidazolidine-2-ones. The N-alkylation of 5-benzylideneimidazolidine-2,4-dione led simultaneously to mono- and dialkylated derivatives. The nucleophilic addition of 1-methyl-3-benzylimidazolidine-2,4-dione with 2-cyano-3-(3,4-dichlorophenyl) acrylate also yielded the 3-substituted 5-arylideneimidazolidine-2,4-dione derivative. Antimicrobial in vitro activity was determined on some compounds.
Subject(s)
Anti-Bacterial Agents/chemical synthesis , Imidazoles/chemical synthesis , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Colony Count, Microbial , Gas Chromatography-Mass Spectrometry , Imidazoles/chemistry , Imidazoles/pharmacologyABSTRACT
The synthesis and physico-chemical properties of fourteen 4-thio-5-arylidene-thiazolidine-2-ones and eight 3-(4-bromophenacyl)-4-thio-5-arylidene-thiazolidine-2-ones are described. These products were synthetized by the aldolisation-crotonisation reaction between aromatic aldehydes and 4-thio-thiazolidine-2-one followed by N-alkylation of this substituted compounds.
Subject(s)
Thiazoles/chemical synthesis , Thiazoles/chemistry , Thiazoles/pharmacologyABSTRACT
Synthesis and physico-chemical properties of four 3-benzyl or 3-(4-chlorobenzyl)-4-thioxo-5-arylazo-imidazolidin-2-ones, five 3-(4-nitrobenzyl)-5-arylidenethiazolidine-2,4-diones and three 3-(4-phenyl-phenacyl)-4-thioxo-5-arylidenethiazolidin-2-ones have been described. These new products were synthesized by an aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted thioxothiazolidin-2-ones or thiazolidine-2,4-diones. The arylazo-imidazolidine compounds were synthesized by copulation of diazonium ions with imidazolidines. Antimicrobial activity was determined for some compounds.
Subject(s)
Anti-Infective Agents/chemical synthesis , Antifungal Agents/chemical synthesis , Thiazoles/chemical synthesis , Anti-Infective Agents/chemistry , Anti-Infective Agents/pharmacology , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Thiazoles/chemistry , Thiazoles/pharmacologyABSTRACT
Inhibitory activities towards human Placental aromatase of novel pyrrolidinone and piperidinone drugs were investigated and compared with those of aminoglutethimide (AG) in vitro. All compounds showing a stronger inhibitory effect than this of AG had the following common structural feature: an imidazole side-chain in C-3 position, with a substituted or non-substituted aromatic ring in the C-2 position and an aliphatic chain (n-butyl or n-octyl) or a phenyl moiety on the nitrogen of the pyrrolidone or piperidone ring. When the C-3 side-chain did not bear any imidazole ring, no activity was observed. Respective Ki values for the competitive inhibition exerted by the more potent inhibitors 10, 11, 13 and 21 with androstenedione as substrate were 19.2, 20.3, 16.8 and 15.4 microM, respectively (Ki AG= 77.0 microM).
Subject(s)
Aromatase Inhibitors , Enzyme Inhibitors/pharmacology , Piperidones/pharmacology , Placenta/enzymology , Pyrrolidinones/pharmacology , Aminoglutethimide/pharmacology , Drug Evaluation, Preclinical , Enzyme Inhibitors/chemistry , Humans , Imidazoles/chemistry , Piperidones/chemistry , Placenta/drug effects , Pyrrolidinones/chemistry , Structure-Activity RelationshipABSTRACT
Synthesis and physico-chemical properties of six 3-(4-bromophenacyl)-5-arylidene-thiazolidine-2,4-diones and eight 3-(4-chlorobenzyl)-5-arylidene-4-thio-imidazolidine-2-ones are described. These products were synthesized by an aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted thiazolidine-2,4-diones or 4-thio-imidazolidine-2-ones. Hypoglycemic and peripheral antinociceptive activities were investigated for these compounds.
Subject(s)
Analgesics/chemical synthesis , Hypoglycemic Agents/chemical synthesis , Imidazoles/chemical synthesis , Thiazoles/chemical synthesis , Alkylation , Analgesics/pharmacology , Animals , Blood Glucose/metabolism , Hypoglycemic Agents/pharmacology , Imidazoles/pharmacology , Magnetic Resonance Spectroscopy , Mice , Pain Measurement/drug effects , Structure-Activity Relationship , Thiazoles/pharmacologyABSTRACT
The synthesis and the physico-chemical properties of four 3-(4-bromophenacyl)-5-arylidene-thiazolidine-2,4-diones, two 3-(4-bromobenzyl)-5-arylidene-thiazolidine-2,4-diones and seven 3-(4-chlorobenzyl)-5-arylidene-4-thio-imidazolidine-2-ones were described. These products were synthetized by the aldolisation-crotonisation reaction between aromatic aldehydes and substituted thiazolidinediones or thio-imidazolidinones.
Subject(s)
Hypoglycemic Agents/chemistry , Hypoglycemic Agents/chemical synthesis , Imidazoles/chemistry , Imidazoles/chemical synthesis , Imidazolidines , Thiazoles/chemistry , Thiazoles/chemical synthesis , Thiazolidinediones , Brain Edema/drug therapy , Humans , Hypoglycemic Agents/pharmacology , Imidazoles/pharmacology , Thiazoles/pharmacologyABSTRACT
Synthesis and physico-chemical properties of nine 3-(4-fluoro or chlorobenzyl)-5-arylidène-imidazolidine-2,4-diones, four 3-(4-fluoro or bromobenzyl)-5-arylidène-thiazolidine-2,4-diones and three 3-)4-bromophénacyl)-5-arylidène-thiazolidine-2,4- diones has been described. These compounds were synthesized by aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted imidazolidine-2,4-diones or thiazolidine-2,4-diones. In vitro cytotoxic activity was determined for compounds 8, 17, 18, 21 and 22.
Subject(s)
Antineoplastic Agents/chemical synthesis , Imidazoles/chemical synthesis , Thiazoles/chemical synthesis , Antineoplastic Agents/pharmacology , Humans , Imidazoles/pharmacology , KB Cells , Thiazoles/pharmacologyABSTRACT
The synthesis of 54 3-phenacyl-5-benzylidene-thiazolidine-2,4-diones is reported. Eight of them were tested for anti-oedema, analgesic and anticonvulsant activity. Only one compound showed significant anti-oedematous and analgesic activity. Three compounds protected against tonic seizures and death.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Thiazoles/chemical synthesis , Animals , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Anticonvulsants/chemical synthesis , Anticonvulsants/pharmacology , Chromatography, Thin Layer , Edema/chemically induced , Edema/prevention & control , Immersion , Magnetic Resonance Spectroscopy , Male , Mass Spectrometry , Mice , Rats , Seizures/chemically induced , Seizures/prevention & control , Spectrophotometry, Infrared , Thiazoles/pharmacology , Thiazoles/toxicityABSTRACT
Several series of benzimidazole and imidazole derivatives have been synthesized and their biological activity evaluated. Their ability to inhibit human placental aromatase activity was tested in vitro. Ten of the tested compounds are more active towards aromatase than aminoglutethimide, the reference molecule. The most active compound XI is five times more potent in the same system. Compounds bearing an aryl group substituted by one or two halogen atom(s) (fluorine or chlorine) in position 4 or 2,4 respectively have also the most interesting activity.
Subject(s)
Aromatase Inhibitors , Benzimidazoles/chemical synthesis , Imidazoles/chemical synthesis , Benzimidazoles/pharmacology , Female , Humans , Imidazoles/pharmacology , Stereoisomerism , Structure-Activity RelationshipABSTRACT
Quantitative structure-activity relationships are described for twenty six title compounds. Five compounds exhibit a significant hypoglycemic activity like insulin used as standard. The aim of the present paper is to investigate the contribution of the different substituents in the biological activity. The application of Fujita-Ban and Hansch models has shown that lipophilic and electronic parameters seem to be the best explanation of variance of biological data.
Subject(s)
Hypoglycemia/chemically induced , Imidazoles/pharmacology , Thiazoles/pharmacology , Animals , Female , Male , Mice , Structure-Activity RelationshipABSTRACT
The synthesis of five chlorobenzyl benzylidene imidazolidinediones and four fluorobenzyl benzylidene thiazolidinediones is described. In order to investigate their antimicrobial activity they are evaluated against microorganism such as Candida albicans, Neurospora crassa, Staphylococcus aureus, Mycobacterium smegmatis and Escherichia coli.
Subject(s)
Anti-Infective Agents/chemical synthesis , Benzylidene Compounds/chemical synthesis , Imidazoles/chemical synthesis , Thiazoles/chemical synthesis , Anti-Bacterial Agents , Anti-Infective Agents/pharmacology , Bacteria/drug effects , Benzyl Compounds/chemical synthesis , Benzyl Compounds/pharmacology , Benzylidene Compounds/pharmacology , Fungi/drug effects , Imidazoles/pharmacology , Microbial Sensitivity Tests , Thiazoles/pharmacologyABSTRACT
Fourteen fluoro pyrimidine-4-ones, four fluoro bispyrimidine-4-ones and two fluoro pyrimidine-4-ones with fused ring have been prepared. The reactivity of the carbonyl group of two pyrimidine-4-ones phosphorus oxychloride was studied. The 4-chloro pyrimidines reacted with ammonia or morpholine giving 4-substituted pyrimidines. Eight compounds are evaluated for their anti-inflammatory and anti-convulsivant properties: they were found to be weakly active against oedema and three of them protected rats form tonic convulsions.
Subject(s)
Pyrimidinones/chemical synthesis , Animals , Anti-Inflammatory Agents , Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Anticonvulsants/chemical synthesis , Male , Mice , Pyrimidinones/pharmacologyABSTRACT
Synthesis and physico-chemical properties of five bromobenzyl-benzylidene-imidazolidinediones and five nitrobenzyl- or benzyl-benzylidene-thiazolidinediones are described. The microbiological activity of bromobenzyl-benzylidene-imidazolidinediones against microorganisms such as Candida albicans, Neurospora crassa and Mycobacterium smegmatis are evaluated.
Subject(s)
Anti-Infective Agents/chemical synthesis , Benzylidene Compounds/chemical synthesis , Ethylenethiourea/chemical synthesis , Thiazoles/chemical synthesis , Anti-Bacterial Agents , Anti-Infective Agents/pharmacology , Benzyl Compounds/chemical synthesis , Benzyl Compounds/pharmacology , Benzylidene Compounds/pharmacology , Candida albicans/drug effects , Ethylenethiourea/pharmacology , Mycobacterium/drug effects , Neurospora crassa/drug effects , Thiazoles/pharmacologyABSTRACT
The synthesis of six benzylidene thiazolidine-diones and three benzylidene imidazolidine-diones is described. In order to investigate their antimicrobial activity, they are evaluated against micro-organism such as Staphylococcus aureus, Streptococcus feacalis, Mycobacterium smegmatis and Neurospora crassa.
Subject(s)
Anti-Infective Agents/chemical synthesis , Benzylidene Compounds/chemical synthesis , Hydantoins/chemical synthesis , Thiazoles/chemical synthesis , Anti-Bacterial Agents , Anti-Infective Agents/pharmacology , Bacteria/drug effects , Benzylidene Compounds/pharmacology , Fungi/drug effects , Hydantoins/pharmacology , Microbial Sensitivity Tests , Thiazoles/pharmacologyABSTRACT
The purpose of the present work is the contribution of hydrophobic fragmental constant, molecular connectivity and parachor in the study of the relationship between chemical structure and biological activity. The results obtained in this series of benzylidenes-pyrrols have shown high correlation between these parameters and the antifungal activity of these compounds.
Subject(s)
Antifungal Agents/pharmacology , Benzylidene Compounds/pharmacology , Pyrroles/pharmacology , Antifungal Agents/chemistry , Benzylidene Compounds/chemistry , Chemical Phenomena , Chemistry, Physical , Fungi/drug effects , Microbial Sensitivity Tests , Pyrroles/chemistry , Structure-Activity RelationshipABSTRACT
The synthesis of six benzylidene thiazolidinediones and four benzylidene imidazolidinediones is described. In order to investigate their antifungal activity, they are evaluated against microorganism such as Candida albicans, Neurospora crassa, Staphylococcus aureus and Escherichia coli.
Subject(s)
Candida albicans/drug effects , Escherichia coli/drug effects , Neurospora crassa/drug effects , Staphylococcus aureus/drug effects , Antifungal Agents/chemical synthesis , Antifungal Agents/pharmacology , In Vitro TechniquesABSTRACT
Previous studies led us to hypothesize that a fatty acid analogue, 15-p-iodophenyl-beta-methyl pentadecanoic acid (IMPPA or BMIPP), which is taken up but not quickly metabolized by heart cells, would be a more suitable tracer of cellular viability than thallium-201. Biodistribution studies of 1-14C-IMPPA in conscious, freely moving rats showed that the concentration ratio of radioactivity in the heart with respect to the blood was about 8 for at least 60 min after intravenous administration, permitting its use as a putative tracer in these conscious, freely moving rats. Thereafter, the myocardial uptake of 14C-IMPPA was studied in isoproterenol-treated rats (daily treatment for 10 days in order to induce cardiac hypertrophy and necrotic foci) with respect to control ones. Comparison of myocardial localizations by quantitative autoradiography of the uptake of 201Tl and 14C-IMPPA with that of triphenyltetrazolium chloride (TTC) staining enabled comparative evaluation of nutritional blood flow, localization and uptake of 14C-IMPPA and necrotic foci size. Distributions of 14C-IMPPA and 201Tl in control rats' hearts were homogeneous, like TTC staining. In infarcted hearts, areas of decreased 14C-IMPPA uptake were nearly the same (100% +/- 5%) as those unstained by TTC. These areas were larger than those showing a decrease in thallium uptake (about 70% +/- 5% of the total scar size). Therefore, IMPPA seems to be a more accurate and sensitive indicator of necrosis localization compared with thallium. It may be a useful agent for assessment of myocardial viability by single photon emission tomography (SPET) imaging.