A clinic system to improve preschool vaccinations in a low socioeconomic status population.

OBJECTIVE: To determine if a clinic system to assess and vaccinate preschool-age children at every clinic visit can improve vaccination rates. DESIGN: A nonequivalent control group design contrasting an intervention clinic with a comparison clinic. SETTING: Two urban St Paul, Minn, clinics. The intervention clinic is a family practice residency clinic, and the comparison, clinic is a community health center clinic. PATIENTS: Primarily a low socioeconomic status white population. INTERVENTIONS: A clinic-wide system to identify and vaccinate children at all clinic visits. Appointment personnel, medical assistants, and physicians all had roles in the intervention protocol. MAIN OUTCOME MEASURES: Percentage of children at the 2 clinics who were up-to-date for a primary vaccine series at age 24 months and also at the end of the study collection periods, preintervention and postintervention. RESULTS: The intervention clinic improved the percentage of children up-to-date for a primary vaccine series at age 24 months from 42% to 56% (P = .02), while the percentage at the comparison clinic did not change significantly (P = .81). Similarly, the intervention clinic improved the percentage of children up-to-date for age at the end of the study periods from 49% preintervention to 63% postintervention (P = .02), while the percentage at the comparison clinic did not improve significantly (P = .45). The system was especially useful for children with few visits to the intervention clinic. CONCLUSIONS: Although the intervention clinic resulted in a substantial improvement in vaccination rates for preschool-age children, rates remained well below national goals. A combination of clinic, community, and national initiatives may be needed to ensure appropriate vaccination rates for this challenging patient population.

Late improvements in mobility after acquired brain injuries in children.

The purpose of this investigation was to describe the late improvements in functional mobility in children who have sustained severe acquired anoxic or traumatic brain injuries. Ninety-eight children from a consecutive series of 199 with acquired brain injuries met inclusion criteria. As expected, children with traumatic injuries had better mobility at time of discharge from rehabilitation than did children with anoxic injury. In addition, children with traumatic injuries improved more in mobility status during the first 2 years after injury than did children with anoxic injury. The children who continued to improve in mobility after discharge were unconscious for a shorter time. Children who became community ambulators during the first year after discharge had higher mobility ratings at discharge. Although children who eventually achieved more functional mobility were admitted to rehabilitation service sooner after injury, discriminant analysis revealed that the duration of unconsciousness, and therefore severity of injury, was more closely correlated with the final mobility status.

Automatic garage door openers: hazard for children.

OBJECTIVES: Despite significant advances in automatic garage door opener design, automatic garage door openers continue to severely injure or kill children. In this investigation, we sought to determine the frequency and circumstances of accidents that have caused severe injury or death to children. We also tried to develop a means by which homeowners can evaluate their door openers. METHODS: We present the histories of three children severely injured or killed by automatic garage door openers. We reviewed national data of similar accidents primarily published by the US Product Safety Commission and Underwriters Laboratories. Also, we evaluated 50 automatic door openers for safety of operation. The reversing mechanisms of door openers were tested using a cardiopulmonary resuscitation mannequin, a roll of paper towels, and a block of wood. RESULTS: In the United States, at least 85 children have had permanent brain injury or have died since 1974 as a result of accidents involving automatic door openers. A review of circumstances of the accidents illustrates that accidents are caused both by use of the openers by children and by faults in design. Most accidents have occurred when children have found access to the activation devices and have been entrapped under closing doors that failed to reverse. However, in one case, an adult activated the opener and left the premises before the door completely closed. Our evaluation of 50 garage door openers showed that although 88% percent reversed when encountering a block of wood, 40% failed to reverse when coming down on a supine, child-sized cardiopulmonary resuscitation mannequin. CONCLUSIONS: Automatic garage door openers pose a serious risk of severe injury or death to children. It is probable that many doors would not reverse if they came down on a young child. Therefore, we have devised a way for homeowners to test their door openers that closely mimics our evaluations using the mannequin by using a large roll of paper towels. If the door fails to reverse using this test, we suggest that homeowners disconnect their openers and operate the doors manually until the openers are serviced or replace their automatic openers with one that meets the latest Underwriters Laboratory standards. We also have other recommendations regarding the safe operation of the doors, including improving the safety standards for openers in apartment complexes. Compliance with these recommendations should reduce the number of injuries to children caused by garage door openers.

Perioperative blood loss: the effect of valproate.

The purpose of this investigation was to determine the effect of the use of valproate (VPA) on bleeding and requirement for replacement blood products in patients undergoing major surgical procedures. One hundred thirty-nine patients had posterior spinal fusion performed by 1 of 3 surgeons at our institution from 1987 to 1993. The clinical status of the patient, pre- and postoperative laboratory values, type and extent of instrumentation, surgeon performing the procedure, and medications (including VPA) were variables considered. The outcome measures were intra- and postoperative blood loss and number of blood products used. Intraoperative blood loss was correlated with the method of instrumentation, platelet count, and the surgeon performing the procedure. Postoperative blood loss was correlated with the diagnosis of cerebral palsy. By hierachical stepwise regression analysis, the only outcome measure correlated with VPA was the number of blood products used.

Solid-state mid-infrared laser facilitated coronary angioplasty: clinical and quantitative coronary angiographic results in 112 patients.

BACKGROUND AND OBJECTIVE: Holmium:YAG is a solid-state, investigational coronary laser device. Preliminary reports indicate the clinical potential for this laser; however, its safety and efficacy in a single center experience have not yet been reported and analyzed in detail. STUDY DESIGN, PATIENTS, AND METHODS: One hundred and twelve consecutive symptomatic patients underwent percutaneous holmium:YAG laser (2.1 micron wavelength, 250-600 mJ/pulse, 5 Hz) facilitated coronary angioplasty. Sixty-six patients (Gr 1) had 74 thrombotic lesions, and 46 patients (Gr 2) had 55 thrombus-free stenoses. RESULTS: Overall laser success was achieved in 120 out of 129 lesions (93%), with 95% subsequent balloon angioplasty success. Laser and clinical successes among the two groups were similar. By quantitative coronary angiography, reduction in the percent diameter stenosis (mean +/- SD) was similar (79 +/- 16% to 37 +/- 14% vs. 73 +/- 16% to 37 +/- 11.5%; P = NS) in both groups. However, minimal luminal diameter improved significantly more in Gr 1 patients, (0.7 +/- 0.5 mm to 2.0 +/- 0.5 mm, vs. 0.9 +/- 0.4 mm to 1.8 +/- 0.4 mm, P = 0.03). Angiographic and clinical complications were similar in patients with thrombus and without thrombus. No death, perforation, or Q-wave infarction occurred in the catheterization laboratory in either group. In-hospital mortality occurred in two patients from cardiac causes unrelated to the laser application. Of the 98 patients who reached the 6 month anniversary, 76 (77%) remained asymptomatic. The restenosis rate among the patients who underwent repeat angiography was 50%. CONCLUSIONS: Solid-state, mid-infrared laser can be safely and successfully applied to symptomatic patients with thrombotic and nonthrombotic lesions. Similar to other debulking devices, the effectiveness of this laser in yielding long-term patency has not been proved.

Laser-assisted coronary angioplasty in patients with severely depressed left ventricular function: quantitative coronary angiography and clinical results.

Laser-assisted coronary angioplasty can be successfully applied to lesions not ideal for balloon angioplasty. Patients with severely impaired left ventricular (LV) function and complex coronary artery stenoses who call for percutaneous revascularization are considered a high risk group for balloon angioplasty. In order to determine the feasibility, safety, and acute clinical outcome of a solid state, pulsed wave, mid-infrared (2.1 micron) laser facilitated angioplasty in these patients, data from 112 patients with 129 lesions were analyzed. Patients were identified according to angiographic LV function; group I included 22 patients with left ventricular ejection fraction (LVEF) < or = 40% (mean = 25% +/- 10%) and group II included 90 patients with LVEF > or = 40% (mean = 58% +/- 8%). No difference in age, gender, diabetes, hypertension, tobacco use, history of previous coronary artery bypass surgery (CABGS) or percutaneous transluminal coronary angioplasty was registered between the two groups. Multivessel disease, previous myocardial infarction (MI), and severe angina were more prevalent among group I patients (P = 0.03). No difference was found in lesion location, complexity, length, or calcification between the two groups; although group I had more eccentric lesions. Both groups were treated with the same laser energy level followed by adjunctive balloon angioplasty. One hundred percent procedural success was obtained in group I versus 93% in group II (P = NS). By Q.C.A. (independent core lab), minimal luminol diameter increased in group I from 0.9 +/- 0.5 mm preprocedure to 2.0 +/- 0.5, as compared to 0.8 +/- 0.5 mm to 1.9 +/- 0.5 mm (P = NS) in group II. Stenosis severity improved from 69% +/- 16% preprocedure to 37% +/- 13% postprocedure in group I, as compared to improvement from 78% +/- 16% to 37% +/- 12.7% in group II (P = NS). Overall complication rate was remarkably low, with no death or perforation in either group; emergency CABGS 0% in group I and 1.1% in group II; dissections 4.5% in group I and 8.8% in group II. There was no significant difference in complication rate between the two groups. The results of this study suggest that holmium:YAG laser facilitated coronary angioplasty can be safely performed in patients with severe LV dysfunction, achieving a remarkably high procedural success and low complication rate.

Infant sleep position and the sudden infant death syndrome. A survey of pediatric recommendations.

A questionnaire survey was conducted to assess the impact of the April 1992 American Academy of Pediatrics Task Force Statement, "Infant Positioning and SIDS," on the routine advice provided by pediatricians in Minnesota to families with newborn infants regarding sleep practices, including sleep position. There was a trend toward more discussion between all pediatric practice groups and families regarding infant sleep practices following the AAP Sleep Position Statement (P < 0.001-0.003). Prone sleep recommendations ranged from 9.2% for newborn infants to 21.4% for infants 6 months of age. Recommendations for the supine or lateral sleep positions predominated at all infant ages. Pediatricians in private practice were more likely to identify the AAP Statement as establishing a medicolegal standard (P < 0.05). We conclude that the 1992 AAP Statement has had a significant impact on the routine advice provided to families regarding infant sleep practices, including infant sleep position.

Effectiveness of oral antibiotic treatment in nursing home-acquired pneumonia.

OBJECTIVE: To determine factors associated with success or failure of oral antibiotic treatment for nursing home-acquired pneumonia (NHAP). DESIGN: Retrospective study of outcomes for all identifiable NHAP cases in 1991. SETTING: The Nursing Home Services Program of St. Paul Ramsey Medical Center and 31 metropolitan St. Paul, Minnesota, community nursing homes. PARTICIPANTS: Nursing home (NH) cohort: 124 patients (mean age 85.2 years) with a new respiratory symptom and new infiltrate on portable chest X-ray for whom oral antibiotics were prescribed. Hospital cohort: 74 NH patients (mean age 84.3 years) admitted to hospital with new X-ray infiltrate and pneumonia diagnosis. Supportive care status patients were excluded. Forty-three physician/nurse practitioner (MD/NP) teams were represented. MEASUREMENTS: Nursing home cohort: Outcomes of hospitalization within 14 days or 30-day mortality. A discriminant model was applied to predict outcome and discriminant rule performance was analyzed. Hospital cohort: 30-day mortality. RESULTS: Of 198 episodes of NH pneumonia, 63% were treated in the facility; 30.6% (38) failed NH treatment. Thirty-day mortality was 13%. There was no examination by the MD or NP for 59% of NH-treated episodes. The hospital cohort had a higher mean pulse (P < .05) but a similar frequency of feeding dependence. Hospital cohort mortality was 17.6%. The NH treatment failure group had significantly higher proportions of pulse > 90/min, temperature > 100.5 degrees F, respirations > 30/min, feeding dependence, and mechanically altered diets. A discriminant model using these factors was significant (P = .002). The NH treatment failure rate was 11% for no factors present, 23% for two or fewer factors, and 59.5% for three or more (likelihood ratio 3.1). Thirty-two percent of the hospital cohort had zero or one factor present and were alive at 30 days. CONCLUSION: The majority of NHAP episodes were treated successfully with oral antibiotics, but 31% failed treatment in the NH. Patients with a mechanically altered diet or requiring feeding assistance by staff had significantly higher failure rates. Feeding dependence and need for a mechanically altered diet as well as abnormal vital signs are associated with oral antibiotic treatment failure. These factors should be considered in treatment decisions for NHAP.

Comparisons of alcohol and other drug problems among Minnesota adolescents in 1989 and 1992.

OBJECTIVES: To measure alcohol and other drug use patterns, adverse consequences of substance use, other high-risk behaviors, and their personal and environmental correlates. DESIGN AND SUBJECTS: The survey was administered in 1989 and 1992 to Minnesota public school students in grades 6, 9, and 12. A comparison sample of school districts that participated in both years consisted of 81% of the state's school districts. District samples were weighted to reflect the proportion of actual enrollment by grade among participating districts. RESULTS: Although alcohol and other drug use declined markedly during the 3-year period studied, the proportion of students who reported at least three adverse consequences of their use was identical in 1989 and 1992: 1% of sixth graders, 7% of ninth graders, and 16% of 12th graders. Alcohol was the primary substance of abuse among students, regardless of age or level of substance involvement. The students with three or more adverse consequences of substance use were defined as "problem users" and compared with other students their age. The most commonly reported consequences of use were tolerance, blackouts, violence, and school or job absenteeism. The problem users were approximately two to seven times more likely to report parental alcohol or other drug problems, physical abuse, and sexual abuse than were students their age with fewer consequences or no history of use. They were also two to 15 times more likely than other students to report such correlates as low self-esteem, emotional distress, antisocial behavior, and suicide attempts. The greatest differences were seen among the youngest students. CONCLUSION: Primary health care workers, social service providers, educators, and other front-line personnel who have contact with youths outside the home need to recognize and respond to behavioral and emotional indicators of risk among adolescents.

CQI longitudinally applied to integrated service outcomes.

Citing data collected between 1987 and 1994 at the St. Paul-Ramsey Medical Center, Ramsey Clinic and Ramsey Foundation, Paul A. Sommers, Ph.D., executive vice president and chief administrative officer of Ramsey, Michael G. Luxenberg, president of Professional Data Analysts, and Eric. P. Sommers of the River Falls Clinic, write how CQI has been introduced. The key is the application of inferential evaluation.

Outcome of severe anoxic/ischemic brain injury in children.

The outcome of 25 children who had anoxic or ischemic brain injuries at 2 months to 14 years of age is reported. Follow-up was from 1 to 14 years after injury; causes were near-drowning, 11; suffocation, 7; cardiac arrest, 3; electrocution with cardiac arrest, 2; strangulation, 1; aborted sudden infant death syndrome, 1. All patients were unconscious for at least 24 hours. Of 11 remaining in vegetative states, 5 died. Seven children regained some language skills and are in special education or self-contained classrooms. Seven are profoundly impaired and show only a social smile. Cognitive and motor outcomes were correlated with the severity of injury as indicated by the duration of unconsciousness. All children who regained language skills or the ability to walk were unconscious less than 60 days. Dystonic rigidity was observed in all children who were nonambulatory. Outcome was also correlated with the cause of injury; mortality, cognitive outcome, feeding outcome, and duration of unconsciousness were all worse in children with near-drowning.

Early enteral feeding does not attenuate metabolic response after blunt trauma.

Enteral feeding very early after trauma has been hypothesized to attenuate the stress response and to improve patient outcome. We tested this hypothesis in a prospective, randomized clinical trial in patients with blunt trauma. Following resuscitation and control of bleeding, 52 patients were randomized to receive early feedings (target, < 24 hours) or late feedings (target, 72 hours). Feeding was given via nasoduodenal feeding tubes. A rapid advance technique was used to achieve full volume and strength within 24 hours (goal, 1.5 g protein/kg.day). Patients who underwent at least 5 days of therapy were considered to have completed the study: 38 in all, 19 in each feeding group. Patients were similar in age, gender, Injury Severity Score, and mean PaO2/FiO2 ratio. The early group, however, had more patients with a PaO2/FiO2 < 150. After feeding began, the amount fed per day was the same in both groups. We found no significant differences in metabolic responses as measured by plasma lactate and urinary total nitrogen, catecholamines, and cortisol. Both groups achieved nitrogen retention. In addition, we found no significant differences in intensive care unit (ICU) days, ventilator days, organ system failure, specific types of infections, or mortality, although the early group had a greater number of total infections. In this study, early enteral feeding after blunt trauma neither attenuated the stress response nor altered patient outcome.

Maternal serum alpha-fetoprotein testing: physician experience and attitudes and their influence on patient acceptance.

BACKGROUND: Maternal serum alpha-fetoprotein (MSAFP) testing is complex and controversial. Although patient response to testing has been studied extensively, physician experience with and attitudes toward the test have not been investigated. The purpose of this study was to describe family physician experience with MSAFP testing and determine if physician characteristics and attitudes influence whether the test is offered and whether patients accept it. METHODS: Eight hundred forty-nine Minnesota members of the American Academy of Family Physicians who provide prenatal care were surveyed by mail. Statistical analyses were performed, comparing physician characteristics, their offering of the test, and patient acceptance of the test. RESULTS: The survey response rate was 84%. Eighty-seven percent of the physicians offered MSAFP testing, most of them routinely. However, relatively few patients chose to have the test done. Physicians had concerns about the cost of the test and its effect on maternal anxiety. The strongest predictor of offering the test was whether the physician agreed it was "medically-legally necessary." CONCLUSIONS: Although most Minnesota family physicians offer MSAFP testing they have concerns about the test and its limitations and appear to convey these concerns to their patients.

Call nights and patients care: effects on inpatients at one teaching hospital.

OBJECTIVE: To determine whether the timing and number of patients admitted by internal medicine housestaff under a traditional call schedule affect the resource utilization and outcome of care for those patients. DESIGN: Retrospective cohort study, using existing computerized records. SETTING: University-affiliated 340-bed city/county teaching hospital. PATIENTS/PARTICIPANTS: 22,112 patients discharged from the internal medicine service who had been admitted by an on-call first-year resident between January 1, 1980, and December 31, 1987. MEASUREMENTS AND MAIN RESULTS: Admission after 5:00 PM was associated with decreased hospital length of stay (8.1%, p less than 0.0001), but increased total charges (3.1%, p = 0.007). The relative risk of inpatient mortality for patients admitted at night was 1.21 (p = 0.03). Patients of busier housestaff, as indicated by a larger number of on-call admissions, had lower total charges (1.7% decreased per admission) and no change in risk of inpatient mortality. While no linear relation was found between number of admissions and length of stay, analysis of nonlinear effects revealed that length of stay first rises, then falls as interns receive more on-call admissions. CONCLUSIONS: The number and timing of admissions by on-call internal medicine housestaff are significantly related to length of hospital stay, total charges, and likelihood of inpatient mortality at one teaching hospital. These variations should be considered in planning the reform of residency training programs.

"Crack" use by American middle-class adolescent polydrug abusers.

A 77-item questionnaire on cocaine and "crack" use patterns, and on the addictive, medical, and criminal consequences of such use, was completed by 464 largely white, middle-class, suburban, teenage drug abusers registered in seven geographically disparate outpatient treatment facilities. Of the 130 (28%) who smoked crack, 87 (67%) were designated as "experimenters" (use of crack 1 to 9 times); 20 (15%) were in an intermediate group (smoked crack 10 to 50 times); and 23 (18%) were heavy users (smoked crack more than 50 times). Sixty percent of heavy users progressed from initiation of crack use to its use at least once a week in less than 3 months. Almost 50% of the 87 experimenters and nearly all the 23 heavy users recalled preoccupation with thoughts of crack, rapid loss of the ability to modulate their use of the drug, and rapid development of pharmacologic tolerance. Suspiciousness, mistrust, and depressed mood were associated with the increasing use of crack. Seizures occurred in none of those who used cocaine by snorting it intranasally (without ever smoking crack), in contrast to 1% of the experimenters and 9% of the 43 respondents who had smoked crack at least 10 times. Seven percent of the 87 experimenters versus almost one fourth of the 43 who smoked crack more frequently had injected cocaine intravenously. The use of crack by middle-class adolescents is associated with rapid addiction and with serious behavioral and medical complications.

A survey of drinking patterns during medical school.

Several studies have documented the common use of alcohol among medical students and the significant fraction of students (7% to 17%) who show a pattern of alcohol abuse. Many authors have pointed out the implications of physician impairment due to alcoholism, presently estimated at about 10%. We surveyed 263 junior and senior medical students, and our data support earlier surveys of the prevalence of alcohol abuse and indicate that students tend to drink less heavily and less frequently after entering medical school. The clinically proven CAGE questions used in the survey showed statistically significant associations between heavy or frequent drinking before and during medical school, but only 4.2% of respondents indicated that school officials had asked whether they had a drinking or drug abuse problem. Given these findings, we suggest the routine administration of screening instruments to medical students, using education and minimal intervention strategies with individuals at risk.

The prevalence of Neisseria gonorrhoeae and Chlamydia trachomatis in victims of sexual assault.

The prevalence of Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) in 232 sexual assault victims who presented for examinations between August 1, 1987, and July 31, 1988, was determined. Results are reported for cervical, rectal, and oropharyngeal NG cultures and for cervical and rectal CT smears. Results from a one-week follow-up are also reported. Cervical test results from the initial sexual assault examination were compared with cervical tests on 399 randomly selected female emergency department patients who presented for other gynecological conditions or lower abdominal pain. The victims of sexual assault had ten of 210 positive cervical NG cultures (4.76%), and 13 of 213 positive cervical CT smears (6.1%) at the first visit. These prevalence rates were not significantly different (P = .3058). There were none of 28 positive rectal NG cultures (0%) and one of 22 positive rectal CT smears (4.34%) (P = .451). None of the 43 oral NG cultures was positive. Seventy-three victims returned for follow-up examination. No follow-up cervical, rectal, or oral NG cultures were positive. However, one of 53 follow-up cervical smears for CT was positive, but this was not significantly different than for cervical NG (P = .461). Sexually assaulted patients had ten of 210 (4.76%) cervical NG cultures positive, and nonassaulted patients showed 53 of 393 positives (13.4%) (P less than .001). Assaulted patients had 13 of 213 (6.1%) cervical CT smears positive, and nonassaulted patients showed 33 of 352 (9.3%) positives (P = .11).(ABSTRACT TRUNCATED AT 250 WORDS)

Does sternal fracture increase the risk for aortic rupture?

We retrospectively reviewed the records of 99 patients who suffered sternal fractures between 1968 and 1987. Patients ranged in age from 5 to 86 years. The most common cause of injury was a motor vehicle accident. The 99 patients were compared with a concurrent series of 2,106 patients with chest injuries and no sternal fractures. Traumatic aortic rupture occurred in 2 of 99 patients with sternal fractures (2%) and in 75 of 2,106 patients without sternal fracture (3.6%). This difference was not statistically significant by the Fisher exact test (p = 0.326). We conclude that traumatic aortic rupture does not occur more commonly in patients with sternal fracture when compared with other patients with blunt chest injuries.

An analysis of risk factors for death at the scene following traumatic aortic rupture.

The hospital or medical examiner records of 75 victims of traumatic aortic rupture (TAR) were reviewed retrospectively. Among the 75 victims, 51 (68%) died at the scene. Those dead at the scene had higher Injury Severity Scores, 59.3 +/- 13.8, than those who survived to be hospitalized, 42.6 +/- 13.3 (p less than 0.001). The mean age of victims dead at the scene was not different than the mean age of those who arrived alive at the hospital. The incidence of death at the scene was significantly higher for patients with head injuries (p less than 0.01), victims with a second intrathoracic injury (p less than 0.025), and patients with associated intra-abdominal injury (p less than 0.001) compared to those without these injuries. A second fatal injury occurred in 51 (41.2%) of victims who died at the scene.