ABSTRACT
Taurine (Tau) is an abundant amino acid in polymorphonuclear leukocytes that react with hypochlorous acid to form taurine chloramine (TauCl) under inflammatory conditions. We investigated potential interactions between lymphocytes and TauCl in rats submitted to cecal ligation. Animals were divided into sham or CLP groups (24 or 120 h) to isolate lymphocytes from blood and spleen. Lymphocytes were cultured at a concentration of 1×106 cells/mL and activated by concanavalin A. Tau and TauCl were added at 1, 10, and 100 µM. Cells were incubated with MTT to evaluate cell viability and cytokine concentration in the supernatant was determined. TauCl decreased lymphocyte viability and altered the secretion pattern of important inflammatory mediators in non-specific-phenotype manner. The effort to a is elucidate mechanisms of immune cell (dys)function in sepsis is important to better understand the complex regulation of immune system during sepsis development, and further studies are necessary to confirm TauCl as potential target in this context.
Subject(s)
Sepsis , Spleen , Animals , Cell Survival , Cells, Cultured , Cytokines , Lymphocytes , Rats , Taurine/analogs & derivatives , Taurine/pharmacologyABSTRACT
Resumo O estado da saúde do professor é fundamental para o êxito do processo de ensino. Além dos aspectos intrínsecos, o contexto escolar afeta o bem-estar do educador. O objetivo deste estudo foi identificar os principais fatores psicossociais, estruturais e relacionais na profissão docente. Uma revisão sistemática da literatura, com o uso de pesquisa eletrônica em oito bases de dados, identificou 2.479 artigos sobre o tema, publicados entre 1997 e 2016. Adotaram-se parâmetros métricos e subjetivos para a seleção nesse portfolio e, ao todo, 32 publicações restaram elegíveis para análise, das quais 29 foram publicadas na língua inglesa. Transcorrida a caracterização bibliométrica e de conteúdo do portfolio final, os trabalhos apontaram, como principais resultados de desgaste, os transtornos psicossomáticos, com ênfase para o estresse e a Síndrome de Burnout, além dos distúrbios da voz. A carga de trabalho, as relações interpessoais e as condições do ambiente escolar são destacadas como os maiores agentes dessas enfermidades. Mudanças e adequações de salas de aula, ações de prevenção e suporte social são apontadas como possíveis soluções para garantir a qualidade de vida desses profissionais.
Abstract The state of health of the teacher is fundamental to the success of the teaching process. In addition to the intrinsic aspects, the scholastic context affects the well-being of the educator. The objective of this study was to identify the main psychosocial, structural and relational factors in the teaching profession. A systematic review of the literature, with the use of electronic research in eight databases, identified 2,479 articles on the topic published between 1997 and 2016. Metric and subjective parameters were adopted for selection in this portfolio and, in all, 32 publications were eligible for analysis, of which 29 were published in English. After the bibliometric and content characterization of the final portfolio, the main results of strain were psychosomatic disorders, with an emphasis on stress and the Burnout Syndrome, as well as voice disturbances. Workload, interpersonal relations and conditions of the scholastic environment are highlighted as the major agents of these conditions. Changes and adaptations in classrooms, actions of prevention and social support are pointed out as possible solutions to guarantee the quality of life of these professionals.
Subject(s)
Humans , Psychophysiologic Disorders/etiology , Stress, Psychological/etiology , Voice Disorders/etiology , Educational Personnel/psychology , Occupational Diseases/etiology , Burnout, Professional/etiology , Occupational Health , Workplace/organization & administration , Workplace/psychologyABSTRACT
The state of health of the teacher is fundamental to the success of the teaching process. In addition to the intrinsic aspects, the scholastic context affects the well-being of the educator. The objective of this study was to identify the main psychosocial, structural and relational factors in the teaching profession. A systematic review of the literature, with the use of electronic research in eight databases, identified 2,479 articles on the topic published between 1997 and 2016. Metric and subjective parameters were adopted for selection in this portfolio and, in all, 32 publications were eligible for analysis, of which 29 were published in English. After the bibliometric and content characterization of the final portfolio, the main results of strain were psychosomatic disorders, with an emphasis on stress and the Burnout Syndrome, as well as voice disturbances. Workload, interpersonal relations and conditions of the scholastic environment are highlighted as the major agents of these conditions. Changes and adaptations in classrooms, actions of prevention and social support are pointed out as possible solutions to guarantee the quality of life of these professionals.
O estado da saúde do professor é fundamental para o êxito do processo de ensino. Além dos aspectos intrínsecos, o contexto escolar afeta o bem-estar do educador. O objetivo deste estudo foi identificar os principais fatores psicossociais, estruturais e relacionais na profissão docente. Uma revisão sistemática da literatura, com o uso de pesquisa eletrônica em oito bases de dados, identificou 2.479 artigos sobre o tema, publicados entre 1997 e 2016. Adotaram-se parâmetros métricos e subjetivos para a seleção nesse portfolio e, ao todo, 32 publicações restaram elegíveis para análise, das quais 29 foram publicadas na língua inglesa. Transcorrida a caracterização bibliométrica e de conteúdo do portfolio final, os trabalhos apontaram, como principais resultados de desgaste, os transtornos psicossomáticos, com ênfase para o estresse e a Síndrome de Burnout, além dos distúrbios da voz. A carga de trabalho, as relações interpessoais e as condições do ambiente escolar são destacadas como os maiores agentes dessas enfermidades. Mudanças e adequações de salas de aula, ações de prevenção e suporte social são apontadas como possíveis soluções para garantir a qualidade de vida desses profissionais.
Subject(s)
Educational Personnel/psychology , Occupational Diseases/etiology , Psychophysiologic Disorders/etiology , Stress, Psychological/etiology , Voice Disorders/etiology , Burnout, Professional/etiology , Humans , Occupational Health , Workplace/organization & administration , Workplace/psychologyABSTRACT
We have investigated early programming of body mass in order to understand the multifactorial etiology of obesity. Considering that the renin-angiotensin system (RAS) is expressed and functional in the white adipose tissue (WAT) and modulates its development, we reasoned whether early transitory inhibition of angiotensin-I converting enzyme activity after birth could modify late body mass development. Therefore, newborn Wistar rats were treated with enalapril (10 mg/kg of body mass) or saline, starting at the first day of life until the age of 16 days. Between days ninetieth and hundred and eightieth, a group of these animals received high fat diet (HFD). Molecular, biochemical, histological, and physiological data were collected. Enalapril treated animals presented hyperphagia, overweight, and increased serum level of triglycerides, total cholesterol and leptin, in adult life. Body composition analyses revealed higher fat mass with increased adipocyte size in these animals. Molecular analyses revealed that enalapril treatment increases neuropeptide Y (NPY) and cocaine- and amphetamine-regulated transcript (CART) gene expression in hypothalamus, fatty acid synthase (FAS), and hormone-sensitive lipase (HSL) gene expression in retroperitoneal WAT, and decreases peroxixome proliferators-activated receptor (PPAR)γ, PPARα, uncoupling protein (UCP)2, and UCP3 gene expression in WAT. The results of the current study indicate that enalapril administration during early postnatal development increases body mass, adiposity and serum lipids in adulthood associated with enhanced food intake and decreased metabolic activity in WAT, predisposing to obesity in adulthood.
ABSTRACT
Este artigo refere-se ao relato da proposta de tratamento da pessoa com dependência química em Enfermaria Psiquiátrica (EPs) de Hospital Geral, mais especificamente na Santa Casa de Irati - Paraná, que é hospital de referência para outros oito municípios vizinhos. O objetivo deste é divulgar o trabalho que vem sendo desenvolvido no campo das dependências químicas emhospital geral. Elaborou-se um plano terapêutico que possibilita aos profissionais da saúde intervir junto ao dependente químico no momento de crise, na prevenção da recaída e na reabilitação em um curto período de tempo, oferecendo suporte a este e à sua família, por intermédio de um atendimento rápido e eficaz. Para embasar a presente proposta, fez-se uma coleta de dados relativa ao ano de 2002, de pacientes internados por alcoolismo e outras drogas, concomitantemente com uma pesquisa bibliográfica para estabelecer o perfil de pacientes que procuram este tipo de serviço
