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1.
Bioengineered ; 13(3): 6908-6918, 2022 03.
Article in English | MEDLINE | ID: mdl-35235758

ABSTRACT

Ischemic stroke is one of the leading causes of morbidity and mortality in humans. Cerebral ischemia-reperfusion (CIR) injury serves as a leading cause of stroke. Schisandra chinensis is a well-known Chinese traditional medicine. In this study, we explored the role of Gomisin J (GJ), a compound of S. chinensis, in CIR using a middle cerebral artery occlusion/reperfusion rat model and the possible mechanisms. We identified that GJ reduced neurological scores, cerebral infarction, and water content in the I/R rat brain. Importantly, GJ rescued I/R treatment-reduced neuron survival in the hippocampus, inhibited apoptosis of ischemic tissues in I/R rats, increased B-cell lymphoma-extra-large (Bcl-XL) expression, and reduced the levels of cleaved caspase-3, Bax, cyclooxygenase-2, nuclear factor kappa-B, and nitric oxide in I/R rat brain tissues. Furthermore, GJ treatment enhanced nuclear factor E2 related factor 2 (Nrf2) translocation, heme oxygenase-1 (HO-1) expression, superoxide dismutase and glutathione peroxidase activities, and glutathione level. Overall, GJ treatment GJ attenuates CIR injury by inducing anti-apoptotic, antioxidant, and anti-inflammatory effects in vivo.


Subject(s)
Neuroprotective Agents , Reperfusion Injury , Animals , Anti-Inflammatory Agents/pharmacology , Anti-Inflammatory Agents/therapeutic use , Antioxidants/pharmacology , Apoptosis , Infarction, Middle Cerebral Artery/complications , Infarction, Middle Cerebral Artery/drug therapy , Lignans , Neuroprotective Agents/pharmacology , Oxidative Stress , Polycyclic Compounds , Rats , Rats, Sprague-Dawley , Reperfusion Injury/drug therapy , Reperfusion Injury/metabolism
3.
ACS Appl Mater Interfaces ; 9(30): 25232-25238, 2017 Aug 02.
Article in English | MEDLINE | ID: mdl-28691792

ABSTRACT

Selenium (Se) has great promise to serve as cathode material for rechargeable batteries because of its good conductivity and high theoretical volumetric energy density comparable to sulfur. Herein, we report the preparation of mesoporous nitrogen-doped carbon scaffolds (NCSs) to restrain selenium for advanced lithium-selenium (Li-Se) batteries. The NCSs synthesized by a bottom-up solution-phase method have graphene-like laminar structure and well-distributed mesopores. The unique architecture of NCSs can severe as conductive framework for encapsulating selenium and polyselenides, and provide sufficient pathways to facilitate ion transport. Furthermore, the laminar and porous NCSs can effectively buffer the volume variation during charge/discharge processes. The integrated composite of Se-NCSs has a high Se content and can ensure the complete electrochemical reactions of Se and Li species. When used for Li-Se batteries, the cathodes based on Se-NCSs exhibit high capacity, remarkable cyclability, and excellent rate performance.

5.
Nano Lett ; 17(1): 437-444, 2017 01 11.
Article in English | MEDLINE | ID: mdl-28073275

ABSTRACT

Despite high theoretical energy density, the practical deployment of lithium-sulfur (Li-S) batteries is still not implemented because of the severe capacity decay caused by polysulfide shuttling and the poor rate capability induced by low electrical conductivity of sulfur. Herein, we report a novel sulfur host material based on "sea urchin"-like cobalt nanoparticle embedded and nitrogen-doped carbon nanotube/nanopolyhedra (Co-NCNT/NP) superstructures for Li-S batteries. The hierarchical micromesopores in Co-NCNT/NP can allow efficient impregnation of sulfur and block diffusion of soluble polysulfides by physical confinement, and the incorporation of embedded Co nanoparticles and nitrogen doping (∼4.6 at. %) can synergistically improve the adsorption of polysulfides, as evidenced by beaker cell tests. Moreover, the conductive networks of Co-NCNT/NP interconnected by nitrogen-doped carbon nanotubes (NCNTs) can facilitate electron transport and electrolyte infiltration. Therefore, the specific capacity, rate capability, and cycle stability of Li-S batteries are significantly enhanced. As a result, the Co-NCNT/NP based cathode (loaded with 80 wt % sulfur) delivers a high discharge capacity of 1240 mAh g-1 after 100 cycles at 0.1 C (based on the weight of sulfur), high rate capacity (755 mAh g-1 at 2.0 C), and ultralong cycling life (a very low capacity decay of 0.026% per cycle over 1500 cycles at 1.0 C). Remarkably, the composite cathode with high areal sulfur loading of 3.2 mg cm-2 shows high rate capacities and stable cycling performance over 200 cycles.

6.
Nanoscale ; 9(3): 1237-1243, 2017 Jan 19.
Article in English | MEDLINE | ID: mdl-28050615

ABSTRACT

The design of electrochemically active materials with appropriate structures and compositions is very important for applications in energy conversion and storage devices. Herein, we demonstrate an effective strategy to prepare microporous heteroatom-doped carbon frameworks derived from naturally-abundant pine needles. The preparation procedure is based on the carbonization of pine needles, followed by KOH activation at a temperature range of 700-1000 °C. The resultant nitrogen-doped carbon consists of abundant micropores and an ultrahigh specific surface area (up to 2433 m2 g-1), leading to high performances in electrocatalytic hydrogen evolution reaction (HER) and supercapacitors. Specifically, when the pine needle-derived carbon (activated at 800 °C) serves as a HER electrocatalyst, it exhibits a low onset potential (∼4 mV), a small Tafel slope (∼45.9 mV dec-1) and a remarkable stability over long-term cycling. When evaluated as an electrode material for supercapacitors, the pine needle-derived carbon (activated at 900 °C) demonstrates high specific capacitance (236 F g-1 at 0.1 A g-1), remarkable rate capability (183 F g-1 at even 20 A g-1) and good long-term stability. Notably, the specific capacitance at 2.0 A g-1 increased from ∼205 to ∼227 F g-1 after cycling for 5000 times, owing to the further activation and wetting of the electrodes. This novel and low-cost biomass-derived carbon material is very promising for many applications, especially in electrocatalytic water splitting and supercapacitors.

7.
J Am Chem Soc ; 138(49): 15829-15832, 2016 12 14.
Article in English | MEDLINE | ID: mdl-27960305

ABSTRACT

The research field on perovskite solar cells (PSCs) is seeing frequent record breaking in the power conversion efficiency (PCE). However, organic-inorganic hybrid halide perovskites and organic additives in common hole-transport materials (HTMs) exhibit poor stability against moisture and heat. Here we report the successful fabrication of all-inorganic PSCs without any labile or expensive organic components. The entire fabrication process can be operated in ambient environment without humidity control (e.g., a glovebox). Even without encapsulation, the all-inorganic PSCs present no performance degradation in humid air (90-95% relative humidity, 25 °C) for over 3 months (2640 h) and can endure extreme temperatures (100 and -22 °C). Moreover, by elimination of expensive HTMs and noble-metal electrodes, the cost was significantly reduced. The highest PCE of the first-generation all-inorganic PSCs reached 6.7%. This study opens the door for next-generation PSCs with long-term stability under harsh conditions, making practical application of PSCs a real possibility.

8.
ACS Appl Mater Interfaces ; 8(40): 26834-26841, 2016 Oct 12.
Article in English | MEDLINE | ID: mdl-27627613

ABSTRACT

Here, we report a hierarchical Co3ZnC/carbon nanotube-inserted nitrogen-doped carbon concave-polyhedrons synthesized by direct pyrolysis of bimetallic zeolitic imidazolate framework precursors under a flow of Ar/H2 and subsequent calcination for both high-performance rechargeable Li-ion and Na-ion batteries. In this structure, Co3ZnC nanoparticles were homogeneously distributed in in situ growth carbon nanotube-inserted nitrogen-doped carbon concave-polyhedrons. Such a hierarchical structure offers a synergistic effect to withstand the volume variation and inhibit the aggregation of Co3ZnC nanoparticles during long-term cycles. Meanwhile, the nitrogen-doped carbon and carbon nanotubes in the hierarchical Co3ZnC/carbon composite offer fast electron transportation to achieve excellent rate capability. As anode of Li-ion batteries, the electrode delivered a high reversible capacity (∼800 mA h/g at 0.5 A/g), outstanding high-rate capacity (408 mA h/g at 5.0 A/g), and long-term cycling performance (585 mA h/g after 1500 cycles at 2.0 A/g). In Na-ion batteries, the Co3ZnC/carbon composite maintains a stable capacity of 386 mA h/g at 1.0 A/g without obvious decay over 750 cycles and a superior rate capability (∼500, 448, and 415 mA h/g at 0.2, 0.5, and 1.0 A/g, respectively).

9.
J Mater Sci Mater Med ; 25(6): 1461-9, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24652594

ABSTRACT

Molecularly imprinted poly(hydroxyethyl methacrylate) microspheres (PHEMA MIPMs) were prepared via precipitation polymerization in this article, using gatifloxacin (GFLX), hydroxyethyl methacrylate (HEMA), and ethylene glycol dimethacrylate (EGDMA) as template molecule, functional monomer and cross-linker, respectively. The effects of reaction medium, initial total monomers, cross-linker and molecular imprinting on the polymerization were investigated systematically. The interaction between GFLX and HEMA in pre-solution was studied by UV-Visible spectrophotometer, both size and morphology of products were characterized by a scanning electron microscope. When the total initial monomer concentration was 1 vol%, EGDMA content was 70 mol%, a group of uniform PHEMA MIPMs were prepared at different GFLX/MAA molar ratios, with diameter range from 2.06 ± 0.07 to 2.82 ± 0.20 µm. The results of drug loading and in vitro release experiments demonstrated that PHEMA MIPMs could achieve a higher GFLX loading content and a more acceptable sustained release than non-imprinted ones.


Subject(s)
Acrylates/chemistry , Capsules/chemical synthesis , Delayed-Action Preparations/administration & dosage , Delayed-Action Preparations/chemical synthesis , Fluoroquinolones/administration & dosage , Fluoroquinolones/chemistry , Molecular Imprinting/methods , Polymers/chemistry , Anti-Bacterial Agents/administration & dosage , Anti-Bacterial Agents/chemical synthesis , Capsules/administration & dosage , Diffusion , Gatifloxacin , Materials Testing , Particle Size , Surface Properties
10.
Biomed Mater ; 8(5): 055007, 2013 Oct.
Article in English | MEDLINE | ID: mdl-24057809

ABSTRACT

A soft and biocompatible hydrogel exhibiting a higher loading and the sustained release of gatifloxacin (GFLX) was developed as the potential matrix to fabricate a therapeutic contact lens for curing bacterial keratitis. 2-hydroxyethyl methacrylate (HEMA) and five other kinds of vinyl monomers with different side groups were used as co-monomers. Copolymerization took place in a cornea shaped mould via the gradient temperature-elevating method. The results of drug loading and in vitro release experiments showed that P(HEMA-co-MAA) achieved the highest drug loading of 11.78±0.77 µg mg(-1) among the obtained hydrogels, as well as a slow release. In addition, its physical properties and cytocompatibility were also proved suitable and safe for wearing on the eye surface. In animal experiments, a rat model of bacterial keratitis was established and employed to evaluate the clinical results of certain treatments employing obtained hydrogels; saline and GFLX eye drops were used as negative and positive controls, respectively. Corneal abscess and opacity caused by epithelial erosion and stromal ulceration were almost healed after wearing the drug loaded P(HEMA-co-MAA) hydrogel for 48 h. Its excellent antibacterial effect was also confirmed by testing the bacterial activity in tear extraction via the streak line method.


Subject(s)
Anti-Bacterial Agents/administration & dosage , Bacterial Infections/drug therapy , Contact Lenses , Drug Carriers , Fluoroquinolones/administration & dosage , Hydrogels/chemistry , Keratitis/drug therapy , Animals , Bacterial Infections/microbiology , Cell Line , Gatifloxacin , Humans , Keratitis/microbiology , Methacrylates/chemistry , Polymers/chemistry , Rats , Rats, Sprague-Dawley , Time Factors
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